Search Results - "Webb, Alastair J.S."

Prognostic Significance of Blood Pressure Variability on Beat-to-Beat Monitoring After Transient Ischemic Attack and Stroke by Webb, Alastair J.S, Mazzucco, Sara, Li, Linxin, Rothwell, Peter M

“…BACKGROUND AND PURPOSE—Visit-to-visit and day-to-day blood pressure (BP) variability (BPV) predict an increased risk of cardiovascular events but only reflect…”
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Response of Day-to-Day Home Blood Pressure Variability by Antihypertensive Drug Class After Transient Ischemic Attack or Nondisabling Stroke by Webb, Alastair J.S, Wilson, Michelle, Lovett, Nicola, Paul, Nicola, Fischer, Urs, Rothwell, Peter M

“…BACKGROUND AND PURPOSE—Visit-to-visit variability in systolic blood pressure (SBP) is associated with an increased risk of stroke and was reduced in randomized…”
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Effects of vasodilating medications on cerebral haemodynamics in health and disease: systematic review and meta-analysis by Webb, Alastair J.S

“…OBJECTIVES:Vasodilating antihypertensives prevent stroke and potentially cerebral small vessel disease but their effects on cerebrovascular haemodynamics…”
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Progression of Beat-to-Beat Blood Pressure Variability Despite Best Medical Management by Webb, Alastair J.S., Lawson, Amy, Wartolowska, Karolina, Mazzucco, Sara, Rothwell, Peter M.

“…Beat-to-beat variability in blood pressure (BP) is associated with recurrent stroke despite good control of hypertension. However, no study has identified…”
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Confounding of Cerebral Blood Flow Velocity by Blood Pressure During Breath Holding or Hyperventilation in Transient Ischemic Attack or Stroke by Webb, Alastair J.S., Paolucci, Matteo, Mazzucco, Sara, Li, Linxin, Rothwell, Peter M.

“…BACKGROUND AND PURPOSE—Breath holding (BH) and hyperventilation are used to assess abnormal cerebrovascular reactivity, often in relation to severity of small…”
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Genetically Predicted Blood Pressure Across the Lifespan: Differential Effects of Mean and Pulse Pressure on Stroke Risk by Georgakis, Marios K., Gill, Dipender, Malik, Rainer, Protogerou, Athanase D., Webb, Alastair J.S., Dichgans, Martin

“…Hypertension is the leading risk factor for stroke. Yet, it remains unknown whether blood pressure pulsatility (pulse pressure [PP]) causally affects stroke…”
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Accuracy of the ABC/2 Score for Intracerebral Hemorrhage: Systematic Review and Analysis of MISTIE, CLEAR-IVH, and CLEAR III by Webb, Alastair J.S., Ullman, Natalie L., Morgan, Tim C., Muschelli, John, Kornbluth, Joshua, Awad, Issam A., Mayo, Stephen, Rosenblum, Michael, Ziai, Wendy, Zuccarrello, Mario, Aldrich, Francois, John, Sayona, Harnof, Sagi, Lopez, George, Broaddus, William C., Wijman, Christine, Vespa, Paul, Bullock, Ross, Haines, Stephen J., Cruz-Flores, Salvador, Tuhrim, Stan, Hill, Michael D., Narayan, Raj, Hanley, Daniel F.

“…BACKGROUND AND PURPOSE—The ABC/2 score estimates intracerebral hemorrhage (ICH) volume, yet validations have been limited by small samples and inappropriate…”
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Reliability, reproducibility and validity of dynamic cerebral autoregulation in a large cohort with transient ischaemic attack or minor stroke by Lee, Yun-Kai, Rothwell, Peter M, Payne, Stephen J, Webb, Alastair J S

“…Cerebral autoregulation (CA) is critical to maintenance of cerebral perfusion but its relevance to the risk of stroke and dementia has been under-studied due…”
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Validation of the Montreal Cognitive Assessment Versus Mini-Mental State Examination Against Hypertension and Hypertensive Arteriopathy After Transient Ischemic Attack or Minor Stroke by WEBB, Alastair J. S, PENDLEBURY, Sarah T, LINXIN LI, SIMONI, Michela, LOVETT, Nicola, MEHTA, Ziyah, ROTHWELL, Peter M

“…Lack of reduced cognitive impairment with blood pressure (BP) lowering in trials may reflect use of the Mini-Mental State Examination (MMSE), which is…”
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Magnetic Resonance Imaging Measurement of Transmission of Arterial Pulsation to the Brain on Propranolol Versus Amlodipine by Webb, Alastair J.S, Rothwell, Peter M

“…BACKGROUND AND PURPOSE—Cerebral arterial pulsatility is associated with leukoaraiosis and depends on central arterial pulsatility and arterial stiffness. The…”
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Acute variegate porphyria presenting with reversible cerebral vasoconstriction by Webb, Alastair J.S, Ingale, Harshal, Irani, Sarosh R, Hu, Michele T.M

“…Highlights • This is the first report of cerebral vasospasm in acute variegate porphyria. • Vasospasm is a potential common mechanism in all forms of acute…”
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New Insights Into Cerebrovascular Pathophysiology and Hypertension by Webb, Alastair J.S., Werring, David J.

“…Despite advances in acute management and prevention of cerebrovascular disease, stroke and vascular cognitive impairment together remain the world’s leading…”
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Blood Pressure Determinants of Cerebral White Matter Hyperintensities and Microstructural Injury: UK Biobank Cohort Study by Wartolowska, Karolina A., Webb, Alastair J.S.

“…Small vessel disease and related stroke and dementia risks are linked to aging and hypertension, but it is unclear whether the pulsatile or steady blood…”
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New Insights Into Cerebrovascular Pathophysiology and Hypertension by Webb, Alastair J.S., Werring, David J.

“…Despite advances in acute management and prevention of cerebrovascular disease, stroke and vascular cognitive impairment together remain the world’s leading…”
Get full text

Blood Pressure Determinants of Cerebral White Matter Hyperintensities and Microstructural Injury: UK Biobank Cohort Study by Wartolowska, Karolina A., Webb, Alastair J.S.

“…Small vessel disease and related stroke and dementia risks are linked to aging and hypertension, but it is unclear whether the pulsatile or steady blood…”
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Increased Cerebral Arterial Pulsatility in Patients With Leukoaraiosis: Arterial Stiffness Enhances Transmission of Aortic Pulsatility by Webb, Alastair J.S., Simoni, Michela, Mazzucco, Sara, Kuker, Wilhelm, Schulz, Ursula, Rothwell, Peter M.

“…Arterial stiffening reduces damping of the arterial waveform and hence increases pulsatility of cerebral blood flow, potentially damaging small vessels. In the…”
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Aortic Stiffness, Pulse Pressure, and Cerebral Pulsatility Progress Despite Best Medical Management: The OXVASC Cohort by Webb, Alastair J.S., Lawson, Amy, Wartolowska, Karolina, Mazzucco, Sara, Rothwell, Peter M.

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Circadian and Diurnal Regulation of Cerebral Blood Flow by Webb, Alastair J S, Klerman, Elizabeth B, Mandeville, Emiri T

“…Circadian and diurnal variation in cerebral blood flow directly contributes to the diurnal variation in the risk of stroke, either through factors that trigger…”
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White matter damage due to pulsatile versus steady blood pressure differs by vascular territory: A cross-sectional analysis of the UK Biobank cohort study by Wartolowska, Karolina A, Webb, Alastair JS

“…Small vessel disease is associated with age, mean blood pressure (MAP) and blood pressure pulsatility (PP). We used data from the UK Biobank cohort study to…”
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Aortic Stiffness, Pulse Pressure, and Cerebral Pulsatility Progress Despite Best Medical Management: The OXVASC Cohort by Webb, Alastair J.S., Lawson, Amy, Wartolowska, Karolina, Mazzucco, Sara, Rothwell, Peter M.

“…Increased cerebral arterial pulsatility is associated with cerebral small vessel disease, recurrent stroke, and dementia despite the best medical treatment…”
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