Search Results - "Weaver, David R"

Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes by Yu, Elizabeth A, Weaver, David R

“…The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology in virtually all cells. Disruption of the genes necessary for the…”
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period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1 by Lee, Hyeong-min, Chen, Rongmin, Kim, Hyukmin, Etchegaray, Jean-Pierre, Weaver, David R, Lee, Choogon

“…Mounting evidence suggests that PERIOD (PER) proteins play a central role in setting the speed (period) and phase of the circadian clock. Pharmacological and…”
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Coordination of circadian timing in mammals by Reppert, Steven M, Weaver, David R

“…Time in the biological sense is measured by cycles that range from milliseconds to years. Circadian rhythms, which measure time on a scale of 24 h, are…”
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The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice by Gumz, Michelle L, Stow, Lisa R, Lynch, I Jeanette, Greenlee, Megan M, Rudin, Alicia, Cain, Brian D, Weaver, David R, Wingo, Charles S

“…The mineralocorticoid aldosterone is a major regulator of sodium transport in target epithelia and contributes to the control of blood pressure and cardiac…”
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The Hepatic Circadian Clock Modulates Xenobiotic Metabolism in Mice by DeBruyne, Jason P., Weaver, David R., Dallmann, Robert

“…The circadian clock generates daily cycles of gene expression that regulate physiological processes. The liver plays an important role in xenobiotic metabolism…”
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Clocks and meals keep mice from being cool by van der Vinne, Vincent, Bingaman, Mark J, Weaver, David R, Swoap, Steven J

“…Daily torpor is used by small mammals to reduce daily energy expenditure in response to energetic challenges. Optimizing the timing of daily torpor allows…”
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The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration by Stokes, Kyle, Cooke, Abrial, Chang, Hanna, Weaver, David R, Breault, David T, Karpowicz, Phillip

“…Background & Aims The gastrointestinal syndrome is an illness of the intestine caused by high levels of radiation. It is characterized by extensive loss of…”
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Single-Cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks Involved in the Central Circadian Clock by Park, James, Zhu, Haisun, O'Sullivan, Sean, Ogunnaike, Babatunde A, Weaver, David R, Schwaber, James S, Vadigepalli, Rajanikanth

“…Single-cell heterogeneity confounds efforts to understand how a population of cells organizes into cellular networks that underlie tissue-level function. This…”
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Functionally Complete Excision of Conditional Alleles in the Mouse Suprachiasmatic Nucleus by Vgat-ires-Cre by Weaver, David R., van der Vinne, Vincent, Giannaris, E. Lela, Vajtay, Thomas J., Holloway, Kristopher L., Anaclet, Christelle

“…Mice with targeted gene disruption have provided important information about the molecular mechanisms of circadian clock function. A full understanding of the…”
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Mammalian melatonin receptors: molecular biology and signal transduction by von Gall, Charlotte, Stehle, Jörg H, Weaver, David R

“…The pineal hormone, melatonin, is an important regulator of seasonal reproduction and circadian rhythms. Its effects are mediated via high-affinity melatonin…”
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Distinct patterns of Period gene expression in the suprachiasmatic nucleus underlie circadian clock photoentrainment by advances or delays by Schwartz, William J, Tavakoli-Nezhad, Mahboubeh, Lambert, Christopher M, Weaver, David R, de la Iglesia, Horacio O

“…The circadian clock in the mammalian hypothalamic suprachiasmatic nucleus (SCN) is entrained by the ambient light/dark cycle, which differentially acts to…”
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The Polycomb Group Protein EZH2 Is Required for Mammalian Circadian Clock Function by Etchegaray, Jean-Pierre, Yang, Xiaoming, DeBruyne, Jason P., Peters, Antoine H.F.M., Weaver, David R., Jenuwein, Thomas, Reppert, Steven M.

“…We examined the importance of histone methylation by the polycomb group proteins in the mouse circadian clock mechanism. Endogenous EZH2, a polycomb group…”
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Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus by LeSauter, Joseph, Lambert, Christopher M, Robotham, Margaret R, Model, Zina, Silver, Rae, Weaver, David R

“…Research on the mechanisms underlying circadian rhythmicity and the response of brain and body clocks to environmental and physiological challenges requires…”
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The suprachiasmatic nucleus: a 25-year retrospective by Weaver, D R

“…The suprachiasmatic nuclei (SCN) of the anterior hypothalamus contain the master circadian pacemaker in mammals. On the occasion of the 25th anniversary of the…”
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mCRY1 and mCRY2 Are Essential Components of the Negative Limb of the Circadian Clock Feedback Loop by Kume, Kazuhiko, Zylka, Mark J, Sriram, Sathyanarayanan, Shearman, Lauren P, Weaver, David R, Jin, Xiaowei, Maywood, Elizabeth S, Hastings, Michael H, Reppert, Steven M

“…We determined that two mouse cryptochrome genes, mCry1 and mCry2, act in the negative limb of the clock feedback loop. In cell lines, mPER proteins (alone or…”
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Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro by Etchegaray, Jean-Pierre, Yu, Elizabeth A, Indic, Premananda, Dallmann, Robert, Weaver, David R

“…Casein kinase 1 delta (CK1delta) plays a more prominent role in the regulation of circadian cycle length than its homologue casein kinase 1 epsilon…”
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Melatonin inhibits hippocampal long-term potentiation by Wang, Louisa M., Suthana, Nanthia A., Chaudhury, Dipesh, Weaver, David R., Colwell, Christopher S.

“…The goal of this study is to investigate the effect of the hormone melatonin on long‐term potentiation and excitability measured by stimulating the Schaffer…”
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Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain by Zylka, M J, Shearman, L P, Weaver, D R, Reppert, S M

“…We have cloned and characterized the mouse cDNA of a third mammalian homolog of the Drosophila period gene and designated it mPer3. The mPER3 protein shows…”
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Interacting Molecular Loops in the Mammalian Circadian Clock by Shearman, Lauren P., Sriram, Sathyanarayanan, Weaver, David R., Maywood, Elizabeth S., Chaves, Inẽs, Zheng, Binhai, Kume, Kazuhiko, Lee, Cheng Chi, Gijsbertus T. J. van der Horst, Hastings, Michael H., Reppert, Steven M.

“…We show that, in the mouse, the core mechanism for the master circadian clock consists of interacting positive and negative transcription and translation…”
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Photic Resetting and Entrainment in CLOCK-Deficient Mice by Dallmann, Robert, DeBruyne, Jason P., Weaver, David R.

“…Mice lacking the CLOCK protein have a relatively subtle circadian phenotype, including a slightly shorter period in constant darkness, differences in phase…”
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