Search Results - "Weaver, D.F."

A one-pot synthesis of 3-amino-3-arylpropionic acids by Tan, C.Y.K., Weaver, D.F.

“…3-Aminopropionic acids (β-amino acids) are biologically active compounds of interest in medicinal and pharmaceutical chemistry. Twenty-one…”
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Epilepsy and antiepileptic drug use in elderly people as risk factors for dementia by Carter, M.D, Weaver, D.F, Joudrey, H.R, Carter, A.O, Rockwood, K

“…Abstract Objective To assess the role of epilepsy and antiepileptic drugs (AEDs) as risk factors for probable Alzheimer's disease (AD) and for all dementias in…”
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Theoretical structural explanation for Group I and Group II, type 2A von Willebrand disease mutations by O'BRIEN, L. A., SUTHERLAND, J. J., WEAVER, D. F., LILLICRAP, D.

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Regional access to Acute ischemic stroke intervention by RIOPELLE, R. J, HOWSE, D. C, BOLTON, C, ELSON, S, GROLL, D. L, HOLTOM, D, BRUNET, D. G, JACKSON, A. C, MELANSON, M, WEAVER, D. F

“…Benefit-risk ratios from recombinant tissue plasminogen activator (rtPA) therapy for acute ischemic stroke demonstrate lack of efficacy if intravenous…”
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β-Alanine as a small molecule neurotransmitter by Tiedje, K.E., Stevens, K., Barnes, S., Weaver, D.F.

“…This review discusses the role of β-alanine as a neurotransmitter. β-Alanine is structurally intermediate between α-amino acid (glycine, glutamate) and γ-amino…”
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FR139317, a specific ETA-receptor antagonist, inhibits cerebral activation by intraventricular endothelin-1 in conscious rats by Gross, P M, Weaver, D F, Ho, L T, Pang, J J, Edvinsson, L

“…A comprehensive series of time-related behavioral, physiological and cerebral metabolic studies was conducted using conscious Sprague-Dawley rats to discern…”
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Mechanisms of post-traumatic seizures: a quantum pharmacological analysis of the molecular properties of an epileptogenic focus following iron-induced membrane peroxidation by Dakin, K A, Weaver, D F

“…Late post-traumatic epilepsy following severe head trauma has been well documented. While there is increasing evidence suggesting that iron-induced lipid…”
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Cerebral hypermetabolism produced by intraventricular endothelin-1 in rats: inhibition by nimodipine by Gross, P M, Wainman, D S, Espinosa, F J, Nag, S, Weaver, D F

“…Injection of endothelin-1 (9 pmol) into the lateral cerebral ventricle of rats produced barrel-rotations, convulsions, tonic hindlimb extensions, facial…”
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Surgical planning for temporal lobe epilepsy using a multimodal imaging approach by Gawryluk, J.R., D'Arcy, R.C., Clarke, D.B., Brewer, K.D., Beyea, S.D., Sadler, R.M., Weaver, D.F.

“…Introduction Functional brain mapping has tremendous potential to guide surgical planning for neurological disorders such as temporal lobe epilepsy (TLE). The…”
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N-, α-, and β-Substituted 3-Aminopropionic acids: design, syntheses and antiseizure activities by Tan, C.Y.K, Wainman, D, Weaver, D.F

“…A treatment for epilepsy is proposed based on analogues of 3-aminopropionic acid (β-alanine), a putative neurotransmitter in the central nervous system (CNS)…”
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Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 800 mg / day) in a B.I.D. regimen by Jones, M.W, Blume, W.T, Guberman, A, Lee, M.A, Pillay, N, Weaver, D.F, Veloso, F, Holdich, T.A.H

“…Remacemide hydrochloride is a low-affinity, non-competitive NMDA receptor channel blocker under investigation for the treatment of epilepsy. This double-blind,…”
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Molecular pathogenesis of alcohol withdrawal seizures: The modified lipid-protein interaction mechanism by Tan, C.Y.K., Weaver, D.F.

“…The phrase alcohol withdrawal seizures (AWS) refers to seizures that result from the withdrawal of alcohol after a period of chronic alcohol administration. A…”
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A computational model of the HBK2 potassium channel ion pore by Jin, A Y, Weaver, D F

“…A computational model of the putative ion pore region of the HBK2 potassium channel was developed. Utilizing experimentally derived constraints, conformations…”
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Potent metabolic stimulation of septal gray and cerebral white matter in vivo by intraventricular endothelin and nitric oxide by Gross, P M, Weaver, D F, Wainman, D S, Chew, B H, Espinosa, F J, Nag, S

“…Endothelin-1 (ET) and sodium nitroprusside (SNP, which liberates nitric oxide, NO) were given alone or together into a lateral cerebral ventricle (icv) of…”
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Intraventricular endothelin-1 uncouples the blood flow: metabolism relationship in periventricular structures of the rat brain: involvement of L-type calcium channels by Gross, P M, Zochodne, D W, Wainman, D S, Ho, L T, Espinosa, F J, Weaver, D F

“…Endothelin-1 (ET) produces contraction of cerebral resistance vessels in vitro and in situ, but also is neuroactive causing increases in tissue energy…”
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Theoretical studies on Alzheimer's disease: structures of β-amyloid aggregates by Kim, S.T, Weaver, D.F

“…β-Amyloid peptide (Aβ) accumulation in the brain still remains the hallmark of Alzheimer's disease (AD). In AD, there is a direct relationship between the…”
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Physical Processes at the Surface of the Arctic Tundra by Kelley, J. J., Weaver, D. F.

“…The results of measurements of net total radiation flux and temperatures in the air and surface layers of the tundra and snow near Barrow, Alaska, are…”
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