Search Results - "Weaver, D F"

The Development of New Therapeutics for Alzheimer's Disease by Carter, M D, Simms, G A, Weaver, D F

“…Existing treatments for Alzheimer's disease (AD) fail to address the underlying pathology of the disease; they merely provide short‐lived symptomatic relief…”
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β-Alanine as a small molecule neurotransmitter by Tiedje, K.E., Stevens, K., Barnes, S., Weaver, D.F.

“…This review discusses the role of β-alanine as a neurotransmitter. β-Alanine is structurally intermediate between α-amino acid (glycine, glutamate) and γ-amino…”
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Morphine, Gabapentin, or Their Combination for Neuropathic Pain by Gilron, Ian, Bailey, Joan M, Tu, Dongsheng, Holden, Ronald R, Weaver, Donald F, Houlden, Robyn L

“…In a randomized trial, the combination of morphine and gabapentin led to better pain control than either agent alone in patients with diabetic neuropathy or…”
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Epilepsy and antiepileptic drug use in elderly people as risk factors for dementia by Carter, M.D, Weaver, D.F, Joudrey, H.R, Carter, A.O, Rockwood, K

“…Abstract Objective To assess the role of epilepsy and antiepileptic drugs (AEDs) as risk factors for probable Alzheimer's disease (AD) and for all dementias in…”
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N-, α-, and β-Substituted 3-Aminopropionic acids: design, syntheses and antiseizure activities by Tan, C.Y.K, Wainman, D, Weaver, D.F

“…A treatment for epilepsy is proposed based on analogues of 3-aminopropionic acid (β-alanine), a putative neurotransmitter in the central nervous system (CNS)…”
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Regional access to Acute ischemic stroke intervention by RIOPELLE, R. J, HOWSE, D. C, BOLTON, C, ELSON, S, GROLL, D. L, HOLTOM, D, BRUNET, D. G, JACKSON, A. C, MELANSON, M, WEAVER, D. F

“…Benefit-risk ratios from recombinant tissue plasminogen activator (rtPA) therapy for acute ischemic stroke demonstrate lack of efficacy if intravenous…”
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Theoretical structural explanation for Group I and Group II, type 2A von Willebrand disease mutations by O'BRIEN, L. A., SUTHERLAND, J. J., WEAVER, D. F., LILLICRAP, D.

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A clinical examination technique for mild upper motor neuron paresis of the arm by WEAVER, D. F

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Massive carbamazepine overdose: clinical and pharmacologic observations in five episodes by WEAVER, D. F, CAMFIELD, P, FRASER, A

“…We report five episodes of carbamazepine (CBZ) intoxication in four patients. Clinically, there were four distinct stages: I--coma, seizures (CBZ levels more…”
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Recent advances in research on radiofrequency fields and health by Krewski, D, Byus, C V, Glickman, B W, Lotz, W G, Mandeville, R, McBride, M L, Prato, F S, Weaver, D F

“…Since the Royal Society of Canada report on potential health risks of radiofrequency (RF) fields from wireless telecommunications in the spring of 1999, there…”
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Aspartame exacerbates EEG spike-wave discharge in children with generalized absence epilepsy : a double-blind controlled study by CAMFIELD, P. R, CAMFIELD, C. S, DOOLEY, J. M, GORDON, K, JOLLYMORE, S, WEAVER, D. F

“…There are anecdotal reports of increased seizures in humans after ingestion of aspartame. We studied 10 children with newly diagnosed but untreated generalized…”
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POTENTIAL HEALTH RISKS OF RADIOFREQUENCY FIELDS FROM WIRELESS TELECOMMUNICATION DEVICES by Daniel Krewski, Craig V. Byus, Barry W. Glickman, W. Gregory Lotz, Rosemonde Mandeville, Mary L. McBride, Frank S. Prato, Donald F. Weaver

“…An extensive review is presented of the potential health risks of radiofrequency fields generated by wireless telephones. Among the effects considered are cell…”
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A one-pot synthesis of 3-amino-3-arylpropionic acids by Tan, C.Y.K., Weaver, D.F.

“…3-Aminopropionic acids (β-amino acids) are biologically active compounds of interest in medicinal and pharmaceutical chemistry. Twenty-one…”
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Rational design of anticonvulsants: a quantum pharmacologic study of the ion channel-modulating FMRFamide tetrapeptide as an endogenous anticonvulsant by Dakin, K A, Weaver, D F

“…We applied the computational techniques of quantum pharmacology to examine molecular conformations (shapes and geometries) of the tetrapeptide FMR-Famide…”
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Remacemide hydrochloride as an add-on therapy in epilepsy: a randomized, placebo-controlled trial of three dose levels (300, 600 and 800 mg / day) in a B.I.D. regimen by Jones, M.W, Blume, W.T, Guberman, A, Lee, M.A, Pillay, N, Weaver, D.F, Veloso, F, Holdich, T.A.H

“…Remacemide hydrochloride is a low-affinity, non-competitive NMDA receptor channel blocker under investigation for the treatment of epilepsy. This double-blind,…”
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Eosinophil-induced neurotoxicity: axonal neuropathy, cerebral infarction, and dementia by WEAVER, D. F, HEFFERNAN, L. P, PURDY, R. A, ING, V. W

“…Although beneficial in allergic and parasitic disease, eosinophils exert nonspecific toxic effects upon host tissues, especially the central and peripheral…”
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Determination of octanol-water partition coefficients by an HPLC method for anticonvulsant structure-activity studies by Henczi, M, Nagy, J, Weaver, D F

“…Octanol-water partition coefficients have been measured and calculated for eight clinically relevant anticonvulsants. For some compounds, these are the first…”
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Molecular pathogenesis of alcohol withdrawal seizures: The modified lipid-protein interaction mechanism by Tan, C.Y.K., Weaver, D.F.

“…The phrase alcohol withdrawal seizures (AWS) refers to seizures that result from the withdrawal of alcohol after a period of chronic alcohol administration. A…”
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A new experimental model of epilepsy based on the intraventricular injection of endothelin by Gross, P M, Weaver, D F

“…Injection of endothelin-1 (ET-1, 9 pmol) into a lateral cerebral ventricle (LCV) of rats produces barrel-rolling and other convulsive signs that resemble those…”
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5,5-Diphenyl-2-thiohydantoin by Roszak, A. W., Weaver, D. F.

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