Search Results - "Weaver, Benjamin T."
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Genomic diagnosis for children with intellectual disability and/or developmental delay
Published in Genome medicine (30-05-2017)“…Developmental disabilities have diverse genetic causes that must be identified to facilitate precise diagnoses. We describe genomic data from 371 affected…”
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Journal Article -
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Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells
Published in Science (American Association for the Advancement of Science) (14-09-2018)“…In response to infection, naïve CD4 T cells differentiate into two subpopulations: T follicular helper (T ) cells, which support B cell antibody production,…”
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Journal Article -
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Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage
Published in Immunity (Cambridge, Mass.) (28-05-2010)“…Phenotypic plasticity of T helper 17 (Th17) cells suggests instability of chromatin structure of key genes of this lineage. We identified epigenetic…”
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Journal Article -
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Restricted clonal expression of IL-2 by naive T cells reflects differential dynamic interactions with dendritic cells
Published in The Journal of experimental medicine (07-07-2003)“…Limited frequencies of T cells express IL-2 in primary antigenic responses, despite activation marker expression and proliferation by most clonal members. To…”
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Journal Article -
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Differential IL-2 Expression Defines Developmental Fates of Follicular versus Non-follicular Helper T cells
Published in Science (American Association for the Advancement of Science) (14-09-2018)“…In response to infection, naïve CD4 + T cells differentiate into two types of helpers: T follicular helper (Tfh) cells, which support B-cell antibody…”
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Journal Article -
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The Computational Discovery of Genetic Determinants of Gene Regulatory Variation in Human Liver
Published 01-01-2018“…From its foundations, modern genetic science has focused on understanding the causal connections between genotypes and phenotypes. The emergence of tools and…”
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Dissertation