Search Results - "Weaver, Alice N."

Beyond DNA Repair: Additional Functions of PARP-1 in Cancer by Weaver, Alice N, Yang, Eddy S

“…Poly(ADP-ribose) polymerases (PARPs) are DNA-dependent nuclear enzymes that transfer negatively charged ADP-ribose moieties from cellular…”
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A continuing clinical education course to maintain clinical competencies and foster new clinical knowledge during the graduate school years of MD-PhD training by Cochrane, Graham D, Anwar, Shima D, Weaver, Alice N, Brosius, Stephanie N, Poholek, Catherine H, Allen, Heather, Seay, Randy L, Lorenz, Robin G, Payne, Gregory A, Geisler, William M

“…Most students in MD-PhD programs take a leave of absence from medical school to complete PhD training, which promotes a natural loss of clinical skills and…”
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A molecular guide to systemic therapy in salivary gland carcinoma by Weaver, Alice N., Lakritz, Stephanie, Mandair, Divneet, Ulanja, Mark B., Bowles, Daniel W.

“…Salivary gland carcinomas (SGC) are a rare and variable group of head and neck cancers with historically poor response to cytotoxic chemotherapy and…”
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Is It Safe to Ask the Questions That Matter Most to Me? Observations From a Female Residency Applicant by Weaver, Alice N, Willett, Lisa L

“…Tens of thousands of senior medical students interview for medical residency positions each year. As the applicant pool shifts to include more women, married…”
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Combining Chk1/2 Inhibition with Cetuximab and Radiation Enhances In Vitro and In Vivo Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Zeng, Ling, Beggs, Reena R, Cooper, Tiffiny S, Weaver, Alice N, Yang, Eddy S

“…EGFR inhibition and radiotherapy are potent inducers of DNA damage. Checkpoint kinases 1 and 2 (Chk1/2) are critical regulators of the DNA-damage response,…”
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Review of Current and Future Medical Treatments in Head and Neck Squamous Cell Carcinoma by Lee, Aaron M, Weaver, Alice N, Acosta, Phillip, Harris, Lauren, Bowles, Daniel W

“…Head and neck squamous cell carcinoma (HNSCC) is a complex cancer requiring a multidisciplinary approach. For patients with locally or regionally advanced…”
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DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma by Weaver, Alice N, Cooper, Tiffiny S, Rodriguez, Marcela, Trummell, Hoa Q, Bonner, James A, Rosenthal, Eben L, Yang, Eddy S

“…Patients with human papillomavirus-positive (HPV+) head and neck squamous cell carcinomas (HNSCCs) have increased response to radio- and chemotherapy and…”
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Impact of elective versus required medical school research experiences on career outcomes by Weaver, Alice N, McCaw, Tyler R, Fifolt, Matthew, Hites, Lisle, Lorenz, Robin G

“…Many US medical schools have added a scholarly or research requirement as a potential intervention to increase the number of medical students choosing to…”
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Final outcomes analysis of the cell product SQZ‐PBMC‐HPV Phase 1 trial in incurable HPV16+ solid tumors shows improved overall survival in patients with increased CD8+ T cell tumor infiltration by Weaver, Alice N., Iams, Wade T., Park, Jong Chul, Mita, Monica, Holtick, Udo, Gordon, Michael S., Rodabaugh, Kerry J., Dhani, Neesha, Neupane, Prakash, Taylor, Matthew, Amanda Duvall, E., Jennings, Julia, Miselis, Nathan R., Loughhead, Scott, Warren, Marshelle S., Bernstein, Howard, Klussmann, Jens P., Baranda, Joaquina, Jimeno, Antonio

“…Cancer vaccines strive to induce robust, antigen‐targeted, T‐cell‐mediated immune responses but have struggled to produce meaningful regression in solid…”
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Fostering a diverse regional community of physician-scientist trainees by Pepin, Mark E., Souder, J. Paige, Weaver, Alice N., Lorenz, Robin G., Yacoubian, Talene, Seay, Randy L.

“…Among the many academic challenges faced by dual-degree MD-PhD students is access to professional support networks designed to overcome the unique academic and…”
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Notch Signaling Activation Is Associated with Patient Mortality and Increased FGF1-Mediated Invasion in Squamous Cell Carcinoma of the Oral Cavity by Weaver, Alice N, Burch, M Benjamin, Cooper, Tiffiny S, Della Manna, Deborah L, Wei, Shi, Ojesina, Akinyemi I, Rosenthal, Eben L, Yang, Eddy S

“…Oral squamous cell carcinoma (OSCC) is a cancer subtype that lacks validated prognostic and therapeutic biomarkers, and human papillomavirus status has not…”
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DNA‐PkCS expression in oropharyngeal squamous cell carcinoma: Correlations with human papillomavirus status and recurrence after transoral robotic surgery by Weaver, Alice N., Cooper, Tiffiny S., Wei, Shi, Carroll, William R., Rosenthal, Eben L., Yang, Eddy S.

“…Background Human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (SCC) has improved clinical outcomes compared to HPV‐negative disease…”
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DNA-Pk CS expression in oropharyngeal squamous cell carcinoma: Correlations with human papillomavirus status and recurrence after transoral robotic surgery by Weaver, Alice N, Cooper, Tiffiny S, Wei, Shi, Carroll, William R, Rosenthal, Eben L, Yang, Eddy S

“…Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC) has improved clinical outcomes compared to HPV-negative disease. However, the…”
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Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity by ROHRBACH, TIMOTHY D, JARBOE, JOHN S, ANDERSON, JOSHUA C, TRUMMELL, HOA Q, HICKS, PATRICIA H, WEAVER, ALICE N, YANG, EDDY S, OSTER, ROBERT A, DESHANE, JESSY S, STEELE, CHAD, SIEGAL, GENE P, BONNER, JAMES A, WILLEY, CHRISTOPHER D

“…Lung cancer is the leading cause of cancer related deaths. Common molecular drivers of lung cancer are mutations in receptor tyrosine kinases (RTKs) leading to…”
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Gamification: an Innovative Approach to Reinforce Clinical Knowledge for MD-PhD Students During Their PhD Research Years by Pepin, Mark E., Webb, William M., Boppana, Sushma, Weaver, Alice N., Seay, Randy L., Dempsey, Donald M., Willig, James H., Geisler, William M., Lorenz, Robin G.

“…A longstanding challenge facing MD-PhD students and other dual-degree medical trainees is the loss of clinical knowledge that occurs during the non-medical…”
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MARCKS phosphorylation is modulated by a peptide mimetic of MARCKS effector domain leading to increased radiation sensitivity in lung cancer cell lines by Rohrbach, Timothy D, Jones, Robert B, Hicks, Patricia H, Weaver, Alice N, Cooper, Tiffiny S, Eustace, Nicholas J, Yang, Eddy S, Jarboe, John S, Anderson, Joshua C, Willey, Christopher D

“…Lung cancer is the leading cause of cancer-associated mortality in the United States. Kinase hyperactivation is a known mechanism of tumorigenesis. The…”
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Abstract A32: Upregulation of the Notch signaling pathway is associated with mortality and in vitro cell invasion in squamous cell carcinoma of the oral cavity by Weaver, Alice N., Cooper, Tiffiny S., Manna, Deborah Della, Wei, Shi, Rosenthal, Eben L., Yang, Eddy S.

“…Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with low survival rates, which have not significantly improved despite advances in…”
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DNA-Pk sub(CS) expression in oropharyngeal squamous cell carcinoma: Correlations with human papillomavirus status and recurrence after transoral robotic surgery by Weaver, Alice N, Cooper, Tiffiny S, Wei, Shi, Carroll, William R, Rosenthal, Eben L, Yang, Eddy S

“…Background Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC) has improved clinical outcomes compared to HPV-negative disease…”
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Abstract A1-63: Characterizing the DNA damage repair defect in HPV-positive oropharyngeal squamous cell carcinoma by Weaver, Alice N., Cooper, Tiffiny S., Trummell, Hoa Q., Bonner, James A., Rosenthal, Eben L., Yang, Eddy S.

“…Although tobacco-associated head and neck cancers (HNCs) are declining in incidence, overall HNC rates are escalating due to increasing prevalence of human…”
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