Search Results - "Weatherwax, Anthony"

Catalytic, asymmetric reactions of ketenes and ketene enolates by Paull, Daniel H., Weatherwax, Anthony, Lectka, Thomas

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Performing the Synthesis of a Complex Molecule on Sequentially Linked Columns:  Toward the Development of a “Synthesis Machine” by France, Stefan, Bernstein, Daniel, Weatherwax, Anthony, Lectka, Thomas

“…We describe the diastereoselective synthesis of a pharmaceutically active drug candidate via a column-based system. This methodology is complementary to…”
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Catalytic, Asymmetric Inverse Electron Demand Hetero Diels-Alder Reactions of o-Benzoquinone Derivatives and Ketene Enolates by Daniel H. Paull, Jamison Wolfer, James W. Grebinski, Anthony Weatherwax, Thomas Lectka

“…We present an array of [4+2] cycloaddition reactions between ketene enolates, catalytically derived from acid chlorides and cinchona alkaloid nucleophilic…”
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Recent Developments in Catalytic, Asymmetric α-Halogenation: A New Frontier in Asymmetric Catalysis by France, Stefan, Weatherwax, Anthony, Lectka, Thomas

“…The development of milder and more sophisticated halogenating reagents that offer significantly greater chemoselectivity and stereocontrol than diatomic…”
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Bifunctional Lewis Acid-Nucleophile-Based Asymmetric Catalysis:  Mechanistic Evidence for Imine Activation Working in Tandem with Chiral Enolate Formation in the Synthesis of β-Lactams by France, Stefan, Shah, Meha H, Weatherwax, Anthony, Wack, Harald, Roth, Justine P, Lectka, Thomas

“…We report a mechanistically based study of bifunctional catalyst systems in which chiral nucleophiles work in conjunction with Lewis acids to produce β-lactams…”
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Advances in the Catalytic, Asymmetric Synthesis of β-Lactams by France, Stefan, Weatherwax, Anthony, Taggi, Andrew E, Lectka, Thomas

“…In this Account, we illustrate our contribution to the catalytic, asymmetric synthesis of β-lactams through a flexible [2 + 2] cycloaddition strategy. We also…”
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Catalytic, Enantioselective [4 + 2]-Cycloadditions of Ketene Enolates and o-Quinones:  Efficient Entry to Chiral, α-Oxygenated Carboxylic Acid Derivatives by Bekele, Tefsit, Shah, Meha H, Wolfer, Jamison, Abraham, Ciby J, Weatherwax, Anthony, Lectka, Thomas

“…We report catalytic, enantioselective [4 + 2]-cycloadditions of o-quinones with ketene enolates (derived from readily available acid chlorides) using cinchona…”
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An Anionic Nucleophilic Catalyst System for the Diastereoselective Synthesis of trans-β-Lactams by Weatherwax, Anthony, Abraham, Ciby J, Lectka, Thomas

“…Trans-disubstituted β-lactams show increasing utility and prominence in numerous pharmaceutical applications, making their asymmetric synthesis an attractive…”
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Scalable Methodology for the Catalytic, Asymmetric α-Bromination of Acid Chlorides by Dogo-Isonagie, Cajetan, Bekele, Tefsit, France, Stefan, Wolfer, Jamison, Weatherwax, Anthony, Taggi, Andrew E, Lectka, Thomas

“…The optimization of a practical, catalytic, asymmetric process for the α-bromination of acid chlorides to produce synthetically versatile, optically active…”
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A Mechanistic Study on the Catalytic, Asymmetric α-Bromination of Acid Chlorides by Dogo-Isonagie, Cajetan, Bekele, Tefsit, France, Stefan, Wolfer, Jamison, Weatherwax, Anthony, Taggi, Andrew E., Paull, Daniel H., Dudding, Travis, Lectka, Thomas

“…The mechanism of the catalytic, asymmetric α‐bromination of acid chlorides is probed through a series of crossover experiments, ion‐pairing tests, and kinetic…”
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Development of a New Dimeric Cyclophane Ligand:  Application to Enhanced Diastereo- and Enantioselectivity in the Catalytic Synthesis of β-Lactams by Wack, Harald, France, Stefan, Hafez, Ahmed M, Drury, William J, Weatherwax, Anthony, Lectka, Thomas

“…We detail the synthesis of a new C 2-symmetric bis(cyclophane) ligand system that can be thought of as electronically analogous to binol, but which possesses…”
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Ketenes in asymmetric synthesis by Weatherwax, Anthony

“…This work revolves around the use of ketenes and their catalyst-derived enolates in the synthesis of a variety of synthetically useful and/or biologically…”
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Ketenes in asymmetric synthesis by Weatherwax, Anthony

“…This work revolves around the use of ketenes and their catalyst-derived enolates in the synthesis of a variety of synthetically useful and/or biologically…”
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