Search Results - "Wear, Martin"

Pilot scale production, extraction and purification of a thermostable phycocyanin from Synechocystis sp. PCC 6803 by Puzorjov, Anton, Mert Unal, Suleyman, Wear, Martin A., McCormick, Alistair J.

“…[Display omitted] •Synechocystis sp. PCC 6803 produced thermostable phycocyanin from a self-replicating vector.•Pilot scale (120 L) cultivation without…”
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M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation by Morgan, Hugh P., O'Reilly, Francis J., Wear, Martin A., O'Neill, J. Robert, Fothergill-Gilmore, Linda A., Hupp, Ted, Walkinshaw, Malcolm D.

“…We show that the M2 isoform of pyruvate kinase (M2PYK) exists in equilibrium between monomers and tetramers regulated by allosteric binding of naturally…”
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Molecular basis for Cdk1‐regulated timing of Mis18 complex assembly and CENP‐A deposition by Spiller, Frances, Medina‐Pritchard, Bethan, Abad, Maria Alba, Wear, Martin A, Molina, Oscar, Earnshaw, William C, Jeyaprakash, A Arockia

“…The centromere, a chromosomal locus that acts as a microtubule attachment site, is epigenetically specified by the enrichment of CENP‐A nucleosomes. Centromere…”
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An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor by Yuan, Meng, McNae, Iain W, Chen, Yiyuan, Blackburn, Elizabeth A, Wear, Martin A, Michels, Paul A M, Fothergill-Gilmore, Linda A, Hupp, Ted, Walkinshaw, Malcolm D

“…We have tested the effect of all 20 proteinogenic amino acids on the activity of the M2 isoenzyme of pyruvate kinase (M2PYK) and show that, within…”
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Borealin-nucleosome interaction secures chromosome association of the chromosomal passenger complex by Abad, Maria A, Ruppert, Jan G, Buzuk, Lana, Wear, Martin, Zou, Juan, Webb, Kim M, Kelly, David A, Voigt, Philipp, Rappsilber, Juri, Earnshaw, William C, Jeyaprakash, A Arockia

“…Chromosome association of the chromosomal passenger complex (CPC; consisting of Borealin, Survivin, INCENP, and the Aurora B kinase) is essential to achieve…”
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Wzi Is an Outer Membrane Lectin that Underpins Group 1 Capsule Assembly in Escherichia coli by Bushell, Simon R., Mainprize, Iain L., Wear, Martin A., Lou, Hubing, Whitfield, Chris, Naismith, James H.

“…Many pathogenic bacteria encase themselves in a polysaccharide capsule that provides a barrier to the physical and immunological challenges of the host. The…”
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Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice by McNae, Iain W., Kinkead, James, Malik, Divya, Yen, Li-Hsuan, Walker, Martin K., Swain, Chris, Webster, Scott P., Gray, Nick, Fernandes, Peter M., Myburgh, Elmarie, Blackburn, Elizabeth A., Ritchie, Ryan, Austin, Carol, Wear, Martin A., Highton, Adrian J., Keats, Andrew J., Vong, Antonio, Dornan, Jacqueline, Mottram, Jeremy C., Michels, Paul A. M., Pettit, Simon, Walkinshaw, Malcolm D.

“…The parasitic protist Trypanosoma brucei is the causative agent of Human African Trypanosomiasis, also known as sleeping sickness. The parasite enters the…”
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Identification of novel interferon responsive protein partners of human leukocyte antigen A (HLA-A) using cross-linking mass spectrometry (CLMS) approach by Singh, Ashita, Padariya, Monikaben, Faktor, Jakub, Kote, Sachin, Mikac, Sara, Dziadosz, Alicja, Lam, Tak W., Brydon, Jack, Wear, Martin A., Ball, Kathryn L., Hupp, Ted, Sznarkowska, Alicja, Vojtesek, Borek, Kalathiya, Umesh

“…The interferon signalling system elicits a robust cytokine response against a wide range of environmental pathogenic and internal pathological signals, leading…”
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Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation by Mitchell, Alice Rose, Yuan, Meng, Morgan, Hugh P, McNae, Iain W, Blackburn, Elizabeth A, Le Bihan, Thierry, Homem, Rafael A, Yu, Manda, Loake, Gary J, Michels, Paul A, Wear, Martin A, Walkinshaw, Malcolm D

“…We show here that the M2 isoform of human pyruvate kinase (M2PYK) is susceptible to nitrosation and oxidation, and that these modifications regulate enzyme…”
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A helminth-derived suppressor of ST2 blocks allergic responses by Vacca, Francesco, Chauché, Caroline, Jamwal, Abhishek, Hinchy, Elizabeth C, Heieis, Graham, Webster, Holly, Ogunkanbi, Adefunke, Sekne, Zala, Gregory, William F, Wear, Martin, Perona-Wright, Georgia, Higgins, Matthew K, Nys, Josquin A, Cohen, E Suzanne, McSorley, Henry J

“…The IL-33-ST2 pathway is an important initiator of type 2 immune responses. We previously characterised the HpARI protein secreted by the model intestinal…”
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Inhibition of the ERCC1–XPF structure-specific endonuclease to overcome cancer chemoresistance by McNeil, Ewan M., Astell, Katy R., Ritchie, Ann-Marie, Shave, Steven, Houston, Douglas R., Bakrania, Preeti, Jones, Hayley M., Khurana, Puneet, Wallace, Claire, Chapman, Tim, Wear, Martin A., Walkinshaw, Malcolm D., Saxty, Barbara, Melton, David W.

“…•ERCC1–XPF active site and interaction inhibitors were identified.•ERCC1–XPF heterodimer levels in ovarian cancer cells were reduced.•Active site inhibitors…”
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Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis by Fernandes, Peter M., Kinkead, James, McNae, Iain W., Vásquez‐Valdivieso, Monserrat, Wear, Martin A., Michels, Paul A. M., Walkinshaw, Malcolm D.

“…Trypanosomatids possess glycosome organelles that contain much of the glycolytic machinery, including phosphofructokinase (PFK). We present kinetic and…”
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A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors by De Simone, Alessio, Georgiou, Charis, Ioannidis, Harris, Gupta, Arun A, Juárez-Jiménez, Jordi, Doughty-Shenton, Dahlia, Blackburn, Elizabeth A, Wear, Martin A, Richards, Jonathan P, Barlow, Paul N, Carragher, Neil, Walkinshaw, Malcolm D, Hulme, Alison N, Michel, Julien

“…Cyclophilins (Cyps) are a major family of drug targets that are challenging to prosecute with small molecules because the shallow nature and high degree of…”
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A Truncated Form of HpARI Stabilizes IL-33, Amplifying Responses to the Cytokine by Chauché, Caroline, Vacca, Francesco, Chia, Shin Li, Richards, Josh, Gregory, William F, Ogunkanbi, Adefunke, Wear, Martin, McSorley, Henry J

“…The murine intestinal nematode releases the Alarmin Release Inhibitor (HpARI) - a protein which binds to IL-33 and to DNA, effectively tethering the cytokine…”
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A chicken bioreactor for efficient production of functional cytokines by Herron, Lissa R, Pridans, Clare, Turnbull, Matthew L, Smith, Nikki, Lillico, Simon, Sherman, Adrian, Gilhooley, Hazel J, Wear, Martin, Kurian, Dominic, Papadakos, Grigorios, Digard, Paul, Hume, David A, Gill, Andrew C, Sang, Helen M

“…The global market for protein drugs has the highest compound annual growth rate of any pharmaceutical class but their availability, especially outside of the…”
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A Streamlined, Automated Protocol for the Production of Milligram Quantities of Untagged Recombinant Rat Lactate Dehydrogenase A Using ÄKTAxpressTM by Nowicki, Matthew W, Blackburn, Elizabeth A, McNae, Iain W, Wear, Martin A

“…We developed an efficient, automated 2-step purification protocol for the production of milligram quantities of untagged recombinant rat lactate dehydrogenase…”
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Capping protein: new insights into mechanism and regulation by Wear, Martin A., Cooper, John A.

“…Temporal and spatial control of the actin cytoskeleton are crucial for a range of eukaryotic cellular processes. Capping protein (CP), a ubiquitous highly…”
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A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins by EYKELENBOOM, Jennifer E, BRIGGS, Gareth J, WEAR, Martin A, BLACKBURN, Elizabeth A, BRAMHAM, Janice, MCLNTOSH, Andrew M, BLACKWOOD, Douglas H, MUIR, Walter J, PORTEOUS, David J, KIRSTY MILLAR, J, BRADSHAW, Nicholas J, SOARES, Dinesh C, OGAWA, Fumiaki, CHRISTIE, Sheila, MALAVASI, Elise L. V, MAKEDONOPOULOU, Paraskevi, MACKIE, Shaun, MALLOY, Mary P

“…Disrupted-In-Schizophrenia 1 (DISC1) was identified as a risk factor for psychiatric illness through its disruption by a balanced chromosomal translocation,…”
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A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase by Morgan, Hugh P, Walsh, Martin J, Blackburn, Elizabeth A, Wear, Martin A, Boxer, Matthew B, Shen, Min, Veith, Henrike, McNae, Iain W, Nowicki, Matthew W, Michels, Paul A M, Auld, Douglas S, Fothergill-Gilmore, Linda A, Walkinshaw, Malcolm D

“…PYK (pyruvate kinase) plays a central role in the metabolism of many organisms and cell types, but the elucidation of the details of its function in a systems…”
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Cyclophilin40 isomerase activity is regulated by a temperature-dependent allosteric interaction with Hsp90 by Blackburn, Elizabeth A, Wear, Martin A, Landré, Vivian, Narayan, Vikram, Ning, Jia, Erman, Burak, Ball, Kathryn L, Walkinshaw, Malcolm D

“…Cyclophilin 40 (Cyp40) comprises an N-terminal cyclophilin domain with peptidyl-prolyl isomerase (PPIase) activity and a C-terminal tetratricopeptide repeat…”
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