Search Results - "Ways, D.Kirk"

The role of protein kinase C in the development of the complications of diabetes by Ways, D.Kirk, Sheetz, Matthew J.

“…Diabetes mellitus produces a state of chronic hyperglycemia which in turn leads to the development of severe complications including retinopathy, nephropathy,…”
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Phosphatidylinositol 3-kinase Contributes to Erk1/Erk2 MAP Kinase Activation Associated with Hepatocyte Growth Factor-induced Cell Scattering by Sipeki, Szabolcs, Bander, Erzsébet, Buday, László, Farkas, Gyöngyi, Bácsy, Ernõ, Ways, D.Kirk, Faragó, Anna

“…MAP kinase cascade-dependent responses were investigated during scattering of HepG2 human hepatoma cells stimulated by HGF or phorbol ester. Inhibition of…”
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Activation of Erk1/Erk2 and transiently increased p53 levels together may account for p21 expression associated with phorbol ester-induced transient growth inhibition in HepG2 cells by Sipeki, Szabolcs, Bander, Erzsébet, Ways, D.Kirk, Faragó, Anna

“…In HepG2 cells grown in the presence of serum, enhanced Raf-activation correlated with transient growth inhibition. The activation of Raf was increased either…”
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Protein kinase C decreases the hepatocyte growth factor-induced activation of Erk1/Erk2 MAP kinases by Sipeki, Szabolcs, Bander, Erzsébet, Farkas, Gyöngyi, Gujdár, Annamaria, Ways, D.Kirk, Faragó, Anna

“…HGF and phorbol ester induce the scattering of HepG2 cells. Recently, we have reported that the motility and morphological responses that accompany this…”
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Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets by Samokhin, Gennady P, Jirousek, Michael R, Ways, D.Kirk, Henriksen, Ruth Ann

“…The purpose of these studies was to identify a possible role for protein kinase C in thromboxane production. The effects of four putative protein kinase C…”
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Phorbol Ester-Stimulated Phosphorylation of PU.l: Association With Leukemic Cell Growth Inhibition by Carey, Julie O., Posekany, Karla J., deVente, James E., Pettit, George R., Ways, D.Kirk

“…PU.1, a member of the ets transcription factor family, has been previously shown to be necessary for tetradecanoyl-phorbol-13 acetate (TPA)-induced U937…”
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12-Deoxyphorbol-13-O-phenylacetate-20-acetate is not protein kinase C-beta isozyme-selective in vivo by Kiley, S C, Olivier, A R, Gordge, P C, Ryves, W J, Evans, F J, Ways, D K, Parker, P J

“…The phorbol ester, 12-deoxyphorbol-13-O-phenylacetate-20-acetate (DOPPA) has been shown to activate specifically the protein kinase C (PKC)-beta 1 isozyme in…”
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Interleukin-3 induces translocation and down-regulation of protein kinase C in human platelets by Cook, P P, Chen, J, Ways, D K

“…Protein kinase C (PKC) is a family of phospholipid-dependent kinases that is involved, along with calcium mobilization, in the activation of human platelets…”
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Effects of Phorbol Esters on an Interleukin-3-Dependent Cell Line by McCubrey, James A., Steelman, Linda S., Sandlin, Gail, Riddle, Ruth S., Ways, D.Kirk

“…FDC-P1 is an interleukin-3 (IL-3)-dependent cell line that ceases to proliferate in the absence of IL-3. We have isolated variant cell lines from FDC-P1 that…”
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Enzymatic rationale and preclinical support for a potent protein kinase C beta inhibitor in cancer therapy by Teicher, B A, Alvarez, E, Mendelsohn, L G, Ara, G, Menon, K, Ways, D K

“…The macrocyclic bisindolylmaleimide, LY333531, selectively inhibits protein kinase C beta 1 and beta 2 isoforms with an approximate IC50 of 5 nanomolar. The…”
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