Search Results - "Wayne Alexander, R."

PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases by Xiong, Shiqin, Patrushev, Nikolay, Forouzandeh, Farshad, Hilenski, Lula, Alexander, R. Wayne

“…Cellular senescence and organismal aging predispose age-related chronic diseases, such as neurodegenerative, metabolic, and cardiovascular disorders. These…”
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Vitamin D Status Is Associated With Arterial Stiffness and Vascular Dysfunction in Healthy Humans by Al Mheid, Ibhar, MD, Patel, Riyaz, MD, Murrow, Jonathan, MD, Morris, Alanna, MD, Rahman, Ayaz, MD, Fike, Lucy, MPH, Kavtaradze, Nino, MD, Uphoff, Irina, Hooper, Craig, PhD, Tangpricha, Vin, MD, PhD, Alexander, R. Wayne, MD, PhD, Brigham, Kenneth, MD, Quyyumi, Arshed A., MD

“…Objectives The primary objective of this study was to elucidate mechanisms underlying the link between vitamin D status and cardiovascular disease by exploring…”
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Metformin Beyond Diabetes: Pleiotropic Benefits of Metformin in Attenuation of Atherosclerosis by Forouzandeh, Farshad, Salazar, Gloria, Patrushev, Nikolay, Xiong, Shiqin, Hilenski, Lula, Fei, Baowei, Alexander, R. Wayne

“…Background Clinical studies show that metformin attenuates all‐cause mortality and myocardial infarction compared with other medications for type 2 diabetes,…”
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Oxidative stress is associated with impaired arterial elasticity by Patel, Riyaz S, Al Mheid, Ibhar, Morris, Alanna A, Ahmed, Yusuf, Kavtaradze, Nino, Ali, Sarfraz, Dabhadkar, Kaustubh, Brigham, Kenneth, Hooper, W. Craig, Alexander, R. Wayne, Jones, Dean P, Quyyumi, Arshed A

“…Abstract Aims Arterial stiffening may lead to hypertension, greater left ventricular after-load and adverse clinical outcomes. The underlying mechanisms…”
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A Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial of Adenosine as an Adjunct to Reperfusion in the Treatment of Acute Myocardial Infarction (AMISTAD-II) by Ross, Allan M., Gibbons, Raymond J., Stone, Gregg W., Kloner, Robert A., Alexander, R. Wayne

“…The purpose of this research was to determine the effect of intravenous adenosine on clinical outcomes and infarct size in ST-segment elevation myocardial…”
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Reactive oxygen species as mediators of angiogenesis signaling. Role of NAD(P)H oxidase by Ushio-Fukai, Masuko, Alexander, R. Wayne

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Novel Role of gp91phox-Containing NAD(P)H Oxidase in Vascular Endothelial Growth Factor–Induced Signaling and Angiogenesis by Ushio-Fukai, Masuko, Tang, Yan, Fukai, Tohru, Dikalov, Sergey I, Ma, Yuxian, Fujimoto, Mitsuaki, Quinn, Mark T, Pagano, Patrick J, Johnson, Chad, Alexander, R Wayne

“…ABSTRACT—Vascular endothelial growth factor (VEGF) induces angiogenesis by stimulating endothelial cell proliferation and migration, primarily through the…”
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Novel Role of ARF6 in Vascular Endothelial Growth Factor–Induced Signaling and Angiogenesis by Ikeda, Satoshi, Ushio-Fukai, Masuko, Zuo, Lian, Tojo, Taiki, Dikalov, Sergey, Patrushev, Nikolay A, Alexander, R Wayne

“…Vascular endothelial growth factor (VEGF) stimulates endothelial cell (EC) migration and proliferation primarily through the VEGF receptor-2 (VEGFR2). We have…”
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IQGAP1, a Novel Vascular Endothelial Growth Factor Receptor Binding Protein, Is Involved in Reactive Oxygen Species–Dependent Endothelial Migration and Proliferation by Yamaoka-Tojo, Minako, Ushio-Fukai, Masuko, Hilenski, Lula, Dikalov, Sergey I, Chen, Yuqing E, Tojo, Taiki, Fukai, Tohru, Fujimoto, Mitsuaki, Patrushev, Nikolay A, Wang, Ningning, Kontos, Christopher D, Bloom, George S, Alexander, R Wayne

“…Endothelial cell (EC) proliferation and migration are important for reendothelialization and angiogenesis. We have demonstrated that reactive oxygen species…”
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Oscillatory Shear Stress Stimulates Adhesion Molecule Expression in Cultured Human Endothelium by Chappell, David C, Varner, Signe E, Nerem, Robert M, Medford, Russell M, Alexander, Wayne R

“…Low and oscillatory shear stresses are major features of the hemodynamic environment of sites opposite arterial flow dividers that are predisposed to…”
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Circadian Variation in Vascular Function and Regenerative Capacity in Healthy Humans by Mheid, Ibhar Al, Corrigan, Frank, Shirazi, Farheen, Veledar, Emir, Li, Qunna, Alexander, Wayne R., Taylor, W. Robert, Waller, Edmund K., Quyyumi, Arshed A.

“…Background Progenitor cells (PCs) are mobilized in response to vascular injury to effect regeneration and repair. Recruitment of PCs requires intact nitric…”
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Endothelial Function and Aminothiol Biomarkers of Oxidative Stress in Healthy Adults by Ashfaq, Salman, Abramson, Jerome L, Jones, Dean P, Rhodes, Steven D, Weintraub, William S, Hooper, W Craig, Vaccarino, Viola, Alexander, R Wayne, Harrison, David G, Quyyumi, Arshed A

“…Endothelial dysfunction is known to precede the development of atherosclerosis and results primarily from increased oxidative degradation of NO. We…”
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Epidermal Growth Factor Receptor Transactivation by Angiotensin II Requires Reactive Oxygen Species in Vascular Smooth Muscle Cells by Ushio-Fukai, Masuko, Griendling, Kathy K, Becker, Peter L, Hilenski, Lula, Halleran, Sean, Alexander, R Wayne

“…Angiotensin II (Ang II) is a vasoactive hormone with critical roles in vascular smooth muscle cell growth, an important feature of hypertension and…”
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Mechanisms of Reactive Oxygen Species–Dependent Downregulation of Insulin Receptor Substrate-1 by Angiotensin II by Taniyama, Yoshihiro, Hitomi, Hirofumi, Shah, Anand, Alexander, R Wayne, Griendling, Kathy K

“…OBJECTIVE—Angiotensin II has been implicated in the pathogenesis of the vascular complications of insulin resistance. Recently, serine phosphorylation and…”
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Pilot randomized controlled trial of a Mediterranean diet or diet supplemented with fish oil, walnuts, and grape juice in overweight or obese US adults by Jaacks, Lindsay M, Sher, Salman, Staercke, Christine De, Porkert, Markus, Alexander, Wayne R, Jones, Dean P, Vaccarino, Viola, Ziegler, Thomas R, Quyyumi, Arshed A

“…The 2015-2020 Dietary Guidelines for Americans recommend a Mediterranean-type diet as one of three healthful eating patterns. However, only one previous trial…”
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FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression by Xiong, Shiqin, Salazar, Gloria, Patrushev, Nikolay, Alexander, R. Wayne

“…Forkhead transcription factor FoxO1 and the NAD+-dependent histone deacetylase SIRT1 are evolutionarily conserved regulators of the development of aging,…”
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Effects of a Health‐Partner Intervention on Cardiovascular Risk by Al Mheid, Ibhar, Kelli, Heval Mohamed, Ko, Yi‐An, Hammadah, Muhammad, Ahmed, Hina, Hayek, Salim, Vaccarino, Viola, Ziegler, Thomas R., Gibson, Greg, Lampl, Michelle, Alexander, R. Wayne, Brigham, Ken, Martin, Greg S., Quyyumi, Arshed A.

“…Background Lifestyle modifications are first‐line measures for cardiovascular disease prevention. Whether lifestyle intervention also preserves cardiovascular…”
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Bone marrow mobilization with granulocyte macrophage colony-stimulating factor improves endothelial dysfunction and exercise capacity in patients with peripheral arterial disease by Subramaniyam, Veerappan, MD, Waller, Edmund K., MD, PhD, Murrow, Jonathan R., MD, Manatunga, Amita, PhD, Lonial, Sagar, MD, Kasirajan, Karthikeswar, MD, Sutcliffe, Diane, BS, Harris, Wayne, BS, Taylor, W. Robert, MD, PhD, FACC, Alexander, R. Wayne, MD, PhD, FACC, Quyyumi, Arshed A., MD, FACC

“…Background We hypothesized that granulocyte macrophage colony-stimulating factor (GM-CSF) administration will be safe and will improve endothelial dysfunction…”
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Angiotensin II Induces Monocyte Chemoattractant Protein-1 Gene Expression in Rat Vascular Smooth Muscle Cells by Chen, Xi-Lin, Tummala, Pradyumna E, Olbrych, Matthew T, Alexander, R. Wayne, Medford, Russell M

“…Monocyte infiltration into the vessel wall, a key initial step in the process of atherosclerosis, is mediated in part by monocyte chemoattractant protein-1…”
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Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells by Taniyama, Yoshihiro, Ushio-Fukai, Masuko, Hitomi, Hirofumi, Rocic, Petra, Kingsley, Michael J, Pfahnl, Chun, Weber, David S, Alexander, R Wayne, Griendling, Kathy K

“…Angiotensin II activates a variety of signaling pathways in vascular smooth muscle cells (VSMCs), including the MAPKs and Akt, both of which are required for…”
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