Search Results - "Wayman, Gary A."

Transgenic miR132 alters neuronal spine density and impairs novel object recognition memory by Hansen, Katelin F, Sakamoto, Kensuke, Wayman, Gary A, Impey, Soren, Obrietan, Karl

“…Inducible gene expression plays a central role in neuronal plasticity, learning, and memory, and dysfunction of the underlying molecular events can lead to…”
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activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP by Wayman, Gary A, Davare, Monika, Ando, Hideaki, Fortin, Dale, Varlamova, Olga, Cheng, Hai-Ying M, Marks, Daniel, Obrietan, Karl, Soderling, Thomas R, Goodman, Richard H, Impey, Soren

“…Activity-regulated gene expression is believed to play a key role in the development and refinement of neuronal circuitry. Nevertheless, the transcriptional…”
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An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling by Impey, Soren, Davare, Monika, Lasiek, Adam, Fortin, Dale, Ando, Hideaki, Varlamova, Olga, Obrietan, Karl, Soderling, Thomas R., Goodman, Richard H., Wayman, Gary A.

“…Activity-regulated gene expression is believed to play a key role in the development and refinement of neuronal circuitry. Nevertheless, the transcriptional…”
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PCB-95 Modulates the Calcium-Dependent Signaling Pathway Responsible for Activity-Dependent Dendritic Growth by Wayman, Gary A., Bose, Diptiman D., Yang, Dongren, Lesiak, Adam, Bruun, Donald, Impey, Soren, Ledoux, Veronica, Pessah, Isaac N., Lein, Pamela J.

“…Background: Non-dioxin-like (NDL) polychlorinated biphenyls (PCBs) promote dendritic growth in hippocampal neurons via ryanodine receptor (RyR)-dependent…”
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PCB-95 Promotes Dendritic Growth via Ryanodine Receptor-Dependent Mechanisms by Wayman, Gary A., Yang, Dongren, Bose, Diptiman D., Lesiak, Adam, Ledoux, Veronica, Bruun, Donald, Pessah, Isaac N., Lein, Pamela J.

“…Background: Aroclor 1254 (A1254) interferes with normal dendritic growth and plasticity in the developing rodent brain, but the mechanism(s) mediating this…”
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Leptin Induces Hippocampal Synaptogenesis via CREB-Regulated MicroRNA-132 Suppression of p250GAP by Dhar, Matasha, Zhu, Mingyan, Impey, Soren, Lambert, Talley J, Bland, Tyler, Karatsoreos, Ilia N, Nakazawa, Takanobu, Appleyard, Suzanne M, Wayman, Gary A

“…Leptin acts in the hippocampus to enhance cognition and reduce depression and anxiety. Cognitive and emotional disorders are associated with abnormal…”
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The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation by Lesiak, Adam, Zhu, Mingyan, Chen, Hao, Appleyard, Suzanne M, Impey, Soren, Lein, Pamela J, Wayman, Gary A

“…Non-dioxin-like (NDL) polychlorinated biphenyls (PCBs) are widespread environmental contaminants linked to neuropsychological dysfunction in children. NDL PCBs…”
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A genome-wide screen of CREB occupancy identifies the RhoA inhibitors Par6C and Rnd3 as regulators of BDNF-induced synaptogenesis by Lesiak, Adam, Pelz, Carl, Ando, Hideaki, Zhu, Mingyan, Davare, Monika, Lambert, Talley J, Hansen, Katelin F, Obrietan, Karl, Appleyard, Suzanne M, Impey, Soren, Wayman, Gary A

“…Neurotrophin-regulated gene expression is believed to play a key role in long-term changes in synaptic structure and the formation of dendritic spines…”
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The Chloride Homeostasis of CA3 Hippocampal Neurons Is Not Altered in Fully Symptomatic Mepc2-null Mice by Belaïdouni, Yasmine, Diabira, Diabe, Zhang, Jinwei, Graziano, Jean-Charles, Bader, Francesca, Montheil, Aurelie, Menuet, Clément, Wayman, Gary A, Gaiarsa, Jean-Luc

“…Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused mainly by mutations in the gene. Mouse models of RTT show reduced expression of the…”
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Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus by Dumon, Camille, Belaidouni, Yasmine, Diabira, Diabe, Appleyard, Suzanne M, Wayman, Gary A, Gaiarsa, Jean-Luc

“…The canonical physiological role of leptin is to regulate hunger and satiety acting on specific hypothalamic nuclei. Beyond this key metabolic function; leptin…”
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Developmental Switch of Leptin Action on Network Driven Activity in the Neonatal Rat Hippocampus by Dumon, Camille, Pisella, Lucie, Diabira, Diabe, Belaidouni, Yasmine, Wayman, Gary A, Gaiarsa, Jean-Luc

“…The adipose-derived circulating hormone leptin plays a pivotal role in the control of energy balance and body weight. Sound data indicate that this hormone…”
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Branched dimerization of Tat peptide improves permeability to HeLa and hippocampal neuronal cells by Monreal, I Abrrey, Liu, Qian, Tyson, Katherine, Bland, Tyler, Dalisay, Doralyn S, Adams, Erin V, Wayman, Gary A, Aguilar, Hector C, Saludes, Jonel P

“…A dimeric branched peptide TATp-D designed as an analogue of the HIV-Tat protein transduction domain (TATp), a prototypical cell penetrating peptide (CPP),…”
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Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders by Svitkina, Tatyana, Lin, Wan-Hsin, Webb, Donna J, Yasuda, Ryohei, Wayman, Gary A, Van Aelst, Linda, Soderling, Scott H

“…The small size of dendritic spines belies the elaborate role they play in excitatory synaptic transmission and ultimately complex behaviors. The cytoskeletal…”
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Tropomodulin's Actin-Binding Abilities Are Required to Modulate Dendrite Development by Gray, Kevin T, Stefen, Holly, Ly, Thu N A, Keller, Christopher J, Colpan, Mert, Wayman, Gary A, Pate, Edward, Fath, Thomas, Kostyukova, Alla S

“…There are many unanswered questions about the roles of the actin pointed end capping and actin nucleation by tropomodulins (Tmod) in regulating neural…”
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Leptin potentiates GABAergic synaptic transmission in the developing rodent hippocampus by Guimond, Damien, Diabira, Diabe, Porcher, Christophe, Bader, Francesca, Ferrand, Nadine, Zhu, Mingyan, Appleyard, Suzanne M, Wayman, Gary A, Gaiarsa, Jean-Luc

“…It is becoming increasingly clear that leptin is not only a hormone regulating energy homeostasis but also a neurotrophic factor impacting a number of brain…”
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Calcium Activation of ERK Mediated by Calmodulin Kinase I by Schmitt, John M, Wayman, Gary A, Nozaki, Naohito, Soderling, Thomas R

“…Elevated intracellular Ca 2+ triggers numerous signaling pathways including protein kinases such as the calmodulin-dependent kinases (CaMKs) and the…”
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Phosphorylation of CBP Mediates Transcriptional Activation by Neural Activity and CaM Kinase IV by Impey, Soren, Fong, Amy L., Wang, Yanhong, Cardinaux, Jean-Rene, Fass, Daniel M., Obrietan, Karl, Wayman, Gary A., Storm, Daniel R., Soderling, Thomas R., Goodman, Richard H.

“…Activity-regulated transcription has been implicated in adaptive plasticity in the CNS. In many instances, this plasticity depends upon the transcription…”
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Regulation of Axonal Extension and Growth Cone Motility by Calmodulin-Dependent Protein Kinase I by Wayman, Gary A, Kaech, Stefanie, Grant, Wilmon F, Davare, Monika, Impey, Soren, Tokumitsu, Hiroshi, Nozaki, Naohito, Banker, Gary, Soderling, Thomas R

“…Calcium and calmodulin (CaM) are important signaling molecules that regulate axonal or dendritic extension and branching. The Ca2+-dependent stimulation of…”
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SialoPen peptides are new cationic foldamers with remarkable cell permeability by Monreal, I. Abrrey, Contreras, Erik M., Wayman, Gary A., Aguilar, Hector C., Saludes, Jonel P.

“…The ability to access intracellular targets is of vital importance as the number of identified druggable intracellular targets increases every year. However,…”
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Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity by Wayman, Gary A., Lee, Yong-Seok, Tokumitsu, Hiroshi, Silva, Alcino, Soderling, Thomas R.

“…In the nervous system, many intracellular responses to elevated calcium are mediated by CaM kinases (CaMKs), a family of protein kinases whose activities are…”
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