Search Results - "Way, Luke"

Next-generation sequencing of a combinatorial peptide phage library screened against ubiquitin identifies peptide aptamers that can inhibit the in vitro ubiquitin transfer cascade by Lisowska, Małgorzata, Lickiss, Fiona, Gil-Mir, Maria, Huart, Anne-Sophie, Trybala, Zuzanna, Way, Luke, Hernychova, Lenka, Krejci, Adam, Muller, Petr, Krejcir, Radovan, Zhukow, Igor, Jurczak, Przemyslaw, Rodziewicz-Motowidło, Sylwia, Ball, Kathryn, Vojtesek, Borivoj, Hupp, Ted, Kalathiya, Umesh

“…Defining dynamic protein-protein interactions in the ubiquitin conjugation reaction is a challenging research area. Generating peptide aptamers that target…”
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Rearrangement of mitochondrial pyruvate dehydrogenase subunit dihydrolipoamide dehydrogenase protein-protein interactions by the MDM2 ligand nutlin-3 by Way, Luke, Faktor, Jakub, Dvorakova, Petra, Nicholson, Judith, Vojtesek, Borek, Graham, Duncan, Ball, Kathryn L., Hupp, Ted

“…Drugs targeting MDM2's hydrophobic pocket activate p53. However, these agents act allosterically and have agonist effects on MDM2's protein interaction…”
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Discovering Putative Protein Targets of Small Molecules: A Study of the p53 Activator Nutlin by Nguyen, Minh N, Sen, Neeladri, Lin, Meiyin, Joseph, Thomas Leonard, Vaz, Candida, Tanavde, Vivek, Way, Luke, Hupp, Ted, Verma, Chandra S, Madhusudhan, M. S

“…Small molecule drugs bind to a pocket in disease causing target proteins based on complementarity in shape and physicochemical properties. There is a…”
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A systems wide mass spectrometric based linear motif screen to identify dominant in-vivo interacting proteins for the ubiquitin ligase MDM2 by Nicholson, Judith, Scherl, Alex, Way, Luke, A. Blackburn, Elizabeth, D. Walkinshaw, Malcolm, L. Ball, Kathryn, R. Hupp, Ted

“…Linear motifs mediate protein–protein interactions (PPI) that allow expansion of a target protein interactome at a systems level. This study uses a proteomics…”
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