Search Results - "Waxman, S.G"

Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy by Oliva, M.K, McGarr, T.C, Beyer, B.J, Gazina, E, Kaplan, D.I, Cordeiro, L, Thomas, E, Dib-Hajj, S.D, Waxman, S.G, Frankel, W.N, Petrou, S

“…Abstract In excitatory neurons, SCN2A (NaV 1.2) and SCN8A (NaV 1.6) sodium channels are enriched at the axon initial segment. NaV 1.6 is implicated in several…”
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22 ERYTHROMELALGIA AS A HUMAN MODEL OF C-FIBER HYPEREXCITABILITY by Waxman, S.G.

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Tapered withdrawal of phenytoin removes protective effect in EAE without inflammatory rebound and mortality by Liu, S, Zwinger, P, Black, J.A, Waxman, S.G

“…Abstract Axon degeneration has been identified as a major contributor to non-remitting neurological deficits in patients with multiple sclerosis (MS), which…”
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A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities by Kearney, J.A, Plummer, N.W, Smith, M.R, Kapur, J, Cummins, T.R, Waxman, S.G, Goldin, A.L, Meisler, M.H

“…The GAL879-881QQQ mutation in the cytoplasmic S4–S5 linker of domain 2 of the rat brain IIA sodium channel (Na v1.2) results in slowed inactivation and…”
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Activated polymorphonuclear cells promote injury and excitability of dorsal root ganglia neurons by Shaw, S.K., Owolabi, S.A., Bagley, J., Morin, N., Cheng, E., LeBlanc, B.W., Kim, M., Harty, P., Waxman, S.G., Saab, C.Y.

“…Therapies aimed at depleting or blocking the migration of polymorphonuclear leukocytes (PMN or neutrophils) are partially successful in the treatment of…”
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Sodium currents of large (Aβ-type) adult cutaneous afferent dorsal root ganglion neurons display rapid recovery from inactivation before and after axotomy by Everill, B, Cummins, T.R, Waxman, S.G, Kocsis, J.D

“…Voltage-dependent Na-currents were studied, using whole cell voltage clamp, in acutely dissociated, large (mostly Aβ-fiber type) cutaneous afferent dorsal root…”
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293 Spontaneous impulse generation in C-nociceptors of familial erythromelalgia (FE) patients by Uyanik, O., Quiles, C., Bostock, H., Dib-Hajj, S., Fischer, T., Tyrrell, L., Waxman, S.G., Serra, J.

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46 PHOSPHORYLATION OF SODIUM CHANNEL NAV1.8 BY P38 MAPK INCREASES CURRENT DENSITY IN DRG NEURONS by Hudmon, A., Choi, J., Tyrrell, L., Black, J.A., Rush, A.M., Waxman, S.G., Dib-Hajj, S.D.

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Schwann cells modulate sodium channel expression in spinal sensory neurons in vitro by Hinson, A.W., Gu, X.Q., Dib-Hajj, S., Black, J.A., Waxman, S.G.

“…In order to study the factors that govern the expression of sodium channel α‐, β1‐ and β2‐subunits, the influence that Schwann cells (SC) exert in the…”
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Nav1.9 expression in magnocellular neurosecretory cells of supraoptic nucleus by Black, J.A., Vasylyev, D., Dib-Hajj, S.D., Waxman, S.G.

“…Osmoregulation in mammals is tightly controlled by the release of vasopressin and oxytocin from magnocellular neurosecretory cells (MSC) of the supraoptic…”
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Morphological and physiological properties of neurons after long-term axonal regeneration: observations on chronic and delayed sequelae of peripheral nerve injury by Bowe, C M, Hildebrand, C, Kocsis, J D, Waxman, S G

“…Axonal regeneration has been the focus of extensive investigation of mechanisms which mediate structural and functional recovery after injury to mammalian…”
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Na v 1.7-related small fiber neuropathy: Impaired slow-inactivation and DRG neuron hyperexcitability by Han, C., Hoeijmakers, J.G.J., Ahn, H.-S., Zhao, P., Shah, P., Lauria, G., Gerrits, M.M., te Morsche, R.H.M., Dib-Hajj, S.D., Drenth, J.P.H., Faber, C.G., Merkies, I.S.J., Waxman, S.G.

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NaG: A sodium channel-like mRNA shared by Schwann cells and other neural crest derivatives by Felts, P.A., Black, J.A., Dib-Hajj, S.D., Waxman, S.G.

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Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons by Dib-Hajj, S.D., Tyrrell, L., Cummins, T.R., Black, J.A., Wood, P.M., Waxman, S.G.

“…Two tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels, SNS and NaN, are preferentially expressed in small dorsal root ganglia (DRG) and trigeminal…”
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Expression of Nav1.8 sodium channels perturbs the firing patterns of cerebellar purkinje cells by RENGANATHAN, M, GELDERBLOM, M, BLACK, J. A, WAXMAN, S. G

“…The sensory neuron specific sodium channel Na(v)1.8/SNS exhibits depolarized voltage-dependence of inactivation, slow inactivation and rapid repriming, which…”
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Sodium channel plasticity in painful diabetic neuropathy by Craner, M.J, Black, J.A, Waxman, S.G

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Effects of 4-aminopyridine on rapidly and slowly conducting axons of rat corpus callosum by Preston, R J, Waxman, S G, Kocsis, J D

“…The action potentials of some normal mammalian peripheral myelinated and non-myelinated nerve fibers are known to differ with respect to the role of…”
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Expression of Na v1.8 sodium channels perturbs the firing patterns of cerebellar purkinje cells by Renganathan, M, Gelderblom, M, Black, J.A, Waxman, S.G

“…The sensory neuron specific sodium channel Na v1.8/SNS exhibits depolarized voltage-dependence of inactivation, slow inactivation and rapid repriming, which…”
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Coordinated micropinocytotic activity of adjacent neuronal membranes in mammalian central nervous system by Waxman, S G, Waxman, M, Pappas, G D

“…Neuropil from a number of sites in both mammalian and inframammalian species were examined by electron microscopy. Complex micropinocytotic invaginations in…”
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K +-induced reversal of astrocyte glutamate uptake is limited by compensatory changes in intracellular Na by Longuemare, M.C., Rose, C.R., Farrell, K., Ransom, B.R., Waxman, S.G., Swanson, R.A.

“…Glutamate uptake is coupled to counter-transport of K +, and high external K + concentrations can induce reversal of glutamate uptake in whole-cell patch-clamp…”
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