Search Results - "Waxman, Lloyd"

Characterization of a cyclic olefin polymer microcentrifuge tube by Waxman, Lloyd, Erwin, Rachel L, Vilivalam, Vinod D

“…Here, we describe the properties of a prototype microcentrifuge tube made from the plastic cyclic olefin polymer (COP). This material has been used in the…”
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A Streamlined Bioanalytical Approach to Select a Compatible Primary Container System Early in Drug Development: A Toolbox for the Biopharmaceutical Industry by Singh, Ranjana, Waxman, Lloyd

“…To ensure drug efficacy and patient safety, the importance of interaction between primary container and a biological drug product must not be ignored. The…”
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Host Cell Factor Requirement for Hepatitis C Virus Enzyme Maturation by Waxman, Lloyd, Whitney, Michael, Pollok, Brian A., Kuo, Lawrence C., Darke, Paul L.

“…The cellular chaperone, HSP90, is identified here as an essential factor for the activity of NS2/3 protease of hepatitis C virus. The cleavage activity of…”
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The Herpesvirus Proteases as Targets for Antiviral Chemotherapy by Waxman, Lloyd, Darke, Paul L

“…Viruses of the family Herpesviridae are responsible for a diverse set of human diseases. The available treatments are largely ineffective, with the exception…”
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Biochemical and Structural Characterization of a Novel Class of Inhibitors of the Type 1 Insulin-like Growth Factor and Insulin Receptor Kinases by Bell, Ian M, Stirdivant, Steven M, Ahern, Janet, Culberson, J. Christopher, Darke, Paul L, Dinsmore, Christopher J, Drakas, Robert A, Gallicchio, Steven N, Graham, Samuel L, Heimbrook, David C, Hall, Dawn L, Hua, Jin, Kett, Nathan R, Kim, Annette S, Kornienko, Maria, Kuo, Lawrence C, Munshi, Sanjeev K, Quigley, Amy G, Reid, John C, Trotter, B. Wesley, Waxman, Lloyd H, Williams, Theresa M, Zartman, C. Blair

“…The type 1 insulin-like growth factor receptor (IGF-1R) is often overexpressed on tumor cells and is believed to play an important role in…”
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Model Protein Adsorption on Polymers Explained by Hansen Solubility Parameters by Fang, Liang, Singh, Ranjana, Waxman, Lloyd, Zhao, Cathy

“…Hansen solubility parameters (HSP) theory has been successful in explaining the wettability of organic solvents on polymer surfaces and miscibility of…”
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Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa by Waxman, L. (Merck Sharp and Dohme Research Laboratories, West Point, PA), Smith, D.E, Arcuri, K.E, Vlasuk, G.P

“…A low molecular weight serine protease inhibitor (TAP) was purified from extracts of the soft tick, Ornithodoros moubata. The peptide is a slow, tight-binding…”
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Active Human Cytomegalovirus Protease Is a Dimer (∗) by Darke, Paul L., Cole, James L., Waxman, Lloyd, Hall, Dawn L., Sardana, Mohinder K., Kuo, Lawrence C.

“…The quaternary state of the human cytomegalovirus (hCMV) protease has been analyzed in relation to its catalysis of peptide hydrolysis. Based on results…”
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Stress Factors in Primary Packaging, Transportation and Handling of Protein Drug Products and Their Impact on Product Quality by Narhi, Linda O, Chou, Danny K, Christian, Twinkle R, Gibson, Scott, Jagannathan, Bharat, Jiskoot, Wim, Jordan, Susan, Sreedhara, Alavattam, Waxman, Lloyd, Das, Tapan K

“…Protein-based biologic drugs encounter a variety of stress factors during drug substance (DS) and drug product (DP) manufacturing, and the subsequent steps…”
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Crystal Structure of the Apo, Unactivated Insulin-like Growth Factor-1 Receptor Kinase by Munshi, Sanjeev, Kornienko, Maria, Hall, Dawn L., Reid, John C., Waxman, Lloyd, Stirdivant, Steven M., Darke, Paul L., Kuo, Lawrence C.

“…The x-ray structure of the unactivated kinase domain of insulin-like growth factor-1 receptor (IGFRK-0P) is reported here at 2.7 Å resolution. IGFRK-0P is…”
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Inhibition of Hepatitis C Virus NS2/3 Processing by NS4A Peptides by Darke, Paul L., Jacobs, Amanda R., Waxman, Lloyd, Kuo, Lawrence C.

“…The NS2/3 protease of hepatitis C virus is responsible for a single cleavage in the viral polyprotein between the nonstructural proteins NS2 and NS3. The…”
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Selectivity of Intracellular Proteolysis: Protein Substrates Activate the ATP-Dependent Protease (La) by Waxman, Lloyd, Goldberg, Alfred L.

“…A critical enzyme in protein breakdown in Escherichia coli is protease La (the lon gene product), which hydrolyzes proteins and adenosine triphosphate (ATP) in…”
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ATP-Stimulated Degradation of Oxidatively Modified Superoxide Dismutase by Cathepsin D in Cardiac Tissue Extracts by Strack, Peter R., Waxman, Lloyd, Fagan, Julie M.

“…Proteins modified by oxidants are rapidly degraded by intracellular proteases. Oxidatively modified superoxide dismutase (Ox-SOD) was degraded 2–8 times faster…”
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The Hemoglobin of Arenicola cristata by Waxman, L

“…The chemical and physical properties of the hemoglobin of the polychaete annelid Arenicola cristata have been studied. Gel filtration and ultracentrifugation…”
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Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity by Munshi, Sanjeev, Kornienko, Maria, Hall, Dawn L, Reid, John C, Waxman, Lloyd, Stirdivant, Steven M, Darke, Paul L, Kuo, Lawrence C

“…The x-ray structure of the unactivated kinase domain of insulin-like growth factor-1 receptor (IGFRK-0P) is reported here at 2.7 A resolution. IGFRK-0P is…”
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Inhibition of hepatitis C virus NS2/3 processing by NS4A peptides. Implications for control of viral processing by Darke, P L, Jacobs, A R, Waxman, L, Kuo, L C

“…The NS2/3 protease of hepatitis C virus is responsible for a single cleavage in the viral polyprotein between the nonstructural proteins NS2 and NS3. The…”
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Effects of N 1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on the growth of tumorigenic cell lines in culture by Shi, Xiao-Ping, Yin, Kuo-Chang, Ahern, Janet, Davis, Lenora J., Stern, Andrew M., Waxman, Lloyd

“…N 1-guanyl-1,7-diaminoheptane (GC 7) is a potent inhibitor of deoxyhypusine synthase (DHS), the enzyme that catalyzes the first step in the hypusination of…”
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Activation of the Multicatalytic Endopeptidase by Oxidants. Effects on Enzyme Structure by Strack, Peter R, Waxman, Lloyd, Fagan, Julie M

“…It is well established that the functional properties of proteins can be compromised by oxidative damage and, in vivo, proteins modified by oxidants are…”
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Calcium-activated proteases in mammalian tissues by Waxman, L

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Taurine maintains and stimulates motility of hamster sperm during capacitation in vitro by Mrsny, R J, Waxman, L, Meizel, S

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