Search Results - "Waxman, David J."

Sex differences in the expression of hepatic drug metabolizing enzymes by Waxman, David J, Holloway, Minita G

“…Sex differences in pharmacokinetics and pharmacodynamics characterize many drugs and contribute to individual differences in drug efficacy and toxicity…”
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Genome-Wide Analysis of Chromatin States Reveals Distinct Mechanisms of Sex-Dependent Gene Regulation in Male and Female Mouse Liver by Sugathan, Aarathi, Waxman, David J.

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STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes by Hao, Pengying, Waxman, David J.

“…Growth hormone-activated STAT5b is an essential regulator of sex-differential gene expression in mouse liver; however, its impact on hepatic gene expression…”
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Combination of antiangiogenesis with chemotherapy for more effective cancer treatment by Ma, Jie, Waxman, David J

“…Angiogenesis is a hallmark of tumor development and metastasis and is now a validated target for cancer treatment. However, the survival benefits of…”
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Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice by Melia, Tisha, Waxman, David J

“…Sex-specific transcription characterizes hundreds of genes in mouse liver, many implicated in sex-differential drug and lipid metabolism and disease…”
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Feminization of Male Mouse Liver by Persistent Growth Hormone Stimulation: Activation of Sex-Biased Transcriptional Networks and Dynamic Changes in Chromatin States by Lau-Corona, Dana, Suvorov, Alexander, Waxman, David J.

“…Sex-dependent pituitary growth hormone (GH) secretory profiles-pulsatile in males and persistent in females-regulate the sex-biased, STAT5-dependent expression…”
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Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2 by Lau-Corona, Dana, Bae, Woo Kyun, Hennighausen, Lothar, Waxman, David J

“…Sex differences in the incidence and progression of many liver diseases, including liver fibrosis and hepatocellular carcinoma, are associated with sex-biased…”
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Growth Hormone Regulation of Sex-Dependent Liver Gene Expression by Waxman, David J, O’Connor, Caitlin

“…The liver is a primary target for the action of GH, a pituitary protein hormone that regulates a broad range of physiological processes, including long bone…”
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Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model by Matthews, Bryan J, Melia, Tisha, Waxman, David J

“…Sex differences in gene expression are widespread in the liver, where many autosomal factors act in tandem with growth hormone signaling to regulate individual…”
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Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver by Matthews, Bryan J, Waxman, David J

“…CTCF and cohesin are key drivers of 3D-nuclear organization, anchoring the megabase-scale Topologically Associating Domains (TADs) that segment the genome…”
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Global analysis of expression, maturation and subcellular localization of mouse liver transcriptome identifies novel sex-biased and TCPOBOP-responsive long non-coding RNAs by Goldfarb, Christine N, Waxman, David J

“…While nuclear transcription and RNA processing and localization are well established for protein coding genes (PCGs), these processes are poorly understood for…”
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Plasma growth hormone pulses induce male-biased pulsatile chromatin opening and epigenetic regulation in adult mouse liver by Rampersaud, Andy, Connerney, Jeannette, Waxman, David J

“…Sex differences in plasma growth hormone (GH) profiles, pulsatile in males and persistent in females, regulate sex differences in hepatic STAT5 activation…”
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Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting by Brocker, Chad N., Kim, Donghwan, Melia, Tisha, Karri, Kritika, Velenosi, Thomas J., Takahashi, Shogo, Aibara, Daisuke, Bonzo, Jessica A., Levi, Moshe, Waxman, David J., Gonzalez, Frank J.

“…Exploring the molecular mechanisms that prevent inflammation during caloric restriction may yield promising therapeutic targets. During fasting, activation of…”
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Dynamic, Sex-Differential STAT5 and BCL6 Binding to Sex-Biased, Growth Hormone-Regulated Genes in Adult Mouse Liver by Zhang, Yijing, Laz, Ekaterina V., Waxman, David J.

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Chemical and Hormonal Effects on STAT5b-Dependent Sexual Dimorphism of the Liver Transcriptome by Oshida, Keiyu, Waxman, David J, Corton, J Christopher

“…The growth hormone (GH)-activated transcription factor signal transducer and activator of transcription 5b (STAT5b) is a key regulator of sexually dimorphic…”
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Spatial frequency domain imaging for monitoring immune-mediated chemotherapy treatment response and resistance in a murine breast cancer model by Tank, Anup, Vergato, Cameron, Waxman, David J., Roblyer, Darren

“…Spatial Frequency Domain Imaging (SFDI) can provide longitudinal, label-free, and widefield hemodynamic and scattering measurements of murine tumors in vivo…”
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Disruption of STAT5b-Regulated Sexual Dimorphism of the Liver Transcriptome by Diverse Factors Is a Common Event by Oshida, Keiyu, Vasani, Naresh, Waxman, David J, Corton, J Christopher

“…Signal transducer and activator of transcription 5b (STAT5b) is a growth hormone (GH)-activated transcription factor and a master regulator of sexually…”
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Intermittent Metronomic Drug Schedule Is Essential for Activating Antitumor Innate Immunity and Tumor Xenograft Regression by Chen, Chong-Sheng, Doloff, Joshua C, Waxman, David J

“…Abstract Metronomic chemotherapy using cyclophosphamide (CPA) is widely associated with antiangiogenesis; however, recent studies implicate other immune-based…”
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Unbiased, Genome-Wide In Vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-Specific Liver Gene Expression by Ling, Guoyu, Sugathan, Aarathi, Mazor, Tali, Fraenkel, Ernest, Waxman, David J.

“…Erratum ( vol. 32 , p. 897 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg…”
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Hepatic Long Intergenic Noncoding RNAs: High Promoter Conservation and Dynamic, Sex-Dependent Transcriptional Regulation by Growth Hormone by Melia, Tisha, Hao, Pengying, Yilmaz, Feyza, Waxman, David J.

“…Long intergenic noncoding RNAs (lincRNAs) are increasingly recognized as key chromatin regulators, yet few studies have characterized lincRNAs in a single…”
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