Generation of cloned transgenic pigs rich in omega-3 fatty acids

Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatt...

Full description

Saved in:

Bibliographic Details
Published in:	Nature biotechnology Vol. 24; no. 4; pp. 435 - 436
Main Authors:	Lai, L, Kang, J.X, Li, R, Wang, J, Witt, W.T, Yong, H.Y, Hao, Y, Wax, D.M, Murphy, C.N, Rieke, A
Format:	Journal Article
Language:	English
Published:	New York, NY Nature 01-04-2006 Nature Publishing Group
Subjects:	Animals Animals, Genetically Modified - metabolism Biological and medical sciences Biotechnology Caenorhabditis elegans Cloning Cloning, Organism - methods fatty acid composition Fatty acids Fatty Acids, Omega-3 - genetics Fatty Acids, Omega-3 - metabolism Fundamental and applied biological sciences. Psychology gene expression Genetic engineering Genetic technics Hogs Humans lipogenesis Meat Meat - analysis Methods. Procedures. Technologies Muscle, Skeletal - metabolism omega-3 fatty acids omega-6 fatty acids Protein Engineering - methods stearoyl-CoA desaturase Swine Swine - physiology Tissue Distribution transgenes Transgenic animals Transgenic animals and transgenic plants Enzyme Transgenic animal Stearoyl-CoA desaturase n-3 fatty acid Pig Caenorhabditis elegans Tissue Vertebrata Mammalia n-6 fatty acid Gene Helmintha Nemathelminthia Artiodactyla Oxidoreductases Invertebrata Nematoda Ungulata
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 These authors contributed equally to this work
ISSN:	1087-0156 1546-1696
DOI:	10.1038/nbt1198