Search Results - "Wawrowsky, Kolja A"

Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release by Dagvadorj, Jargalsaikhan, Shimada, Kenichi, Chen, Shuang, Jones, Heather D., Tumurkhuu, Gantsetseg, Zhang, Wenxuan, Wawrowsky, Kolja A., Crother, Timothy R., Arditi, Moshe

“…Acute lung injury (ALI) remains a serious health issue with little improvement in our understanding of the pathophysiology and therapeutic approaches. We…”
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Dedifferentiation and proliferation of mammalian cardiomyocytes by Zhang, Yiqiang, Li, Tao-Sheng, Lee, Shuo-Tsan, Wawrowsky, Kolja A, Cheng, Ke, Galang, Giselle, Malliaras, Konstantinos, Abraham, M Roselle, Wang, Charles, Marbán, Eduardo

“…It has long been thought that mammalian cardiomyocytes are terminally-differentiated and unable to proliferate. However, myocytes in more primitive animals…”
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Inhibition of brain tumor growth by intravenous poly(β-L-malic acid) nanobioconjugate with pH-dependent drug release by Ding, Hui, Inoue, Satoshi, Ljubimov, Alexander V, Patil, Rameshwar, Portilla-Arias, Jose, Hu, Jinwei, Konda, Bindu, Wawrowsky, Kolja A, Fujita, Manabu, Karabalin, Natalya, Sasaki, Takako, Black, Keith L, Holler, Eggehard, Ljubimova, Julia Y

“…Effective treatment of brain neurological disorders such as Alzheimer's disease, multiple sclerosis, or tumors should be possible with drug delivery through…”
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Phosphodiesterase type 5 inhibitors increase Herceptin transport and treatment efficacy in mouse metastatic brain tumor models by Hu, Jinwei, Ljubimova, Julia Y, Inoue, Satoshi, Konda, Bindu, Patil, Rameshwar, Ding, Hui, Espinoza, Andres, Wawrowsky, Kolja A, Patil, Chirag, Ljubimov, Alexander V, Black, Keith L

“…Chemotherapeutic drugs and newly developed therapeutic monoclonal antibodies are adequately delivered to most solid and systemic tumors. However, drug delivery…”
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Fatty Acid Translocase (FAT/CD36) Is Localized on Insulin-Containing Granules in Human Pancreatic β-Cells and Mediates Fatty Acid Effects on Insulin Secretion by NOUSHMEHR, Houtan, D'AMICO, Eugenio, FARILLA, Loredana, HONGXIANG HUI, WAWROWSKY, Kolja A, MLYNARSKI, Wojciech, DORIA, Alessandro, ABUMRAD, Nada A, PERFETTI, Riccardo

“…Fatty Acid Translocase ( FAT/CD36 ) Is Localized on Insulin-Containing Granules in Human Pancreatic β-Cells and Mediates Fatty Acid Effects on Insulin…”
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Somatostatin Receptor Type 5 Modulates Somatostatin Receptor Type 2 Regulation of Adrenocorticotropin Secretion by Ben-Shlomo, Anat, Wawrowsky, Kolja A., Proekt, Irina, Wolkenfeld, Nathaniel M., Ren, Song-Guang, Taylor, John, Culler, Michael D., Melmed, Shlomo

“…Somatostatin inhibits adrenocorticotropin (ACTH) secretion from pituitary tumor cells. To assess the contribution of somatostatin receptor subtype 5 (SST5) to…”
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Temozolomide Delivery to Tumor Cells by a Multifunctional Nano Vehicle Based on Poly(β-L-malic acid) by Patil, Rameshwar, Portilla-Arias, José, Ding, Hui, Inoue, Satoshi, Konda, Bindu, Hu, Jinwei, Wawrowsky, Kolja A, Shin, Paul K, Black, Keith L, Holler, Eggehard, Ljubimova, Julia Y

“…Purpose Temozolomide (TMZ) is a pro-drug releasing a DNA alkylating agent that is the most effective drug to treat glial tumors when combined with radiation…”
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Brain tumor tandem targeting using a combination of monoclonal antibodies attached to biopoly(β- l-malic acid) by Fujita, Manabu, Lee, Bong-Seop, Khazenzon, Natalya M., Penichet, Manuel L., Wawrowsky, Kolja A., Patil, Rameshwar, Ding, Hui, Holler, Eggehard, Black, Keith L., Ljubimova, Julia Y.

“…Tumor-specific targeting using achievements of nanotechnology is a mainstay of increasing efficacy of anti-tumor drugs. To improve drug targeting we covalently…”
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Polycefin, a New Prototype of a Multifunctional Nanoconjugate Based on Poly(β-l-malic acid) for Drug Delivery by Lee, Bong-Seop, Fujita, Manabu, Khazenzon, Natalya M, Wawrowsky, Kolja A, Wachsmann-Hogiu, Sebastian, Farkas, Daniel L, Black, Keith L, Ljubimova, Julia Y, Holler, Eggehard

“…A new prototype of nanoconjugate, Polycefin, was synthesized for targeted delivery of antisense oligonucleotides and monoclonal antibodies to brain tumors. The…”
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3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models by Gertych, Arkadiusz, Oh, Jin Ho, Wawrowsky, Kolja A, Weisenberger, Daniel J, Tajbakhsh, Jian

“…The spatial organization of the genome is being evaluated as a novel indicator of toxicity in conjunction with drug-induced global DNA hypomethylation and…”
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Selective Regulation of Somatostatin Receptor Subtype Signaling: Evidence for Constitutive Receptor Activation by Ben-Shlomo, Anat, Pichurin, Oxana, Barshop, Nicole J, Wawrowsky, Kolja A, Taylor, John, Culler, Michael D, Chesnokova, Vera, Liu, Ning-Ai, Melmed, Shlomo

“…Anterior pituitary hormone secretion is under tonic suppression by hypothalamic somatostatin signaling through somatostatin receptor subtypes (SSTs). Because…”
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Automated quantification of DNA demethylation effects in cells via 3D mapping of nuclear signatures and population homogeneity assessment by Gertych, Arkadiusz, Wawrowsky, Kolja A, Lindsley, Erik, Vishnevsky, Eugene, Farkas, Daniel L, Tajbakhsh, Jian

“…Today's advanced microscopic imaging applies to the preclinical stages of drug discovery that employ high-throughput and high-content three-dimensional (3D)…”
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Evidence that Human Thyroid Cells Express Uncleaved, Single-Chain Thyrotropin Receptors on Their Surface by Chen, Chun-Rong, Chazenbalk, Gregorio D, Wawrowsky, Kolja A, McLachlan, Sandra M, Rapoport, Basil

“…The prevailing concept is that, in human thyroid tissue in vivo, all cell-surface TSH receptors (TSHR) cleave into disulfide linked A and B subunits. Because…”
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Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1[alpha] Release by Dagvadorj, Jargalsaikhan, Shimada, Kenichi, Chen, Shuang, Jones, Heather D, Tumurkhuu, Gantsetseg, Zhang, Wenxuan, Wawrowsky, Kolja A, Crother, Timothy R, Arditi, Moshe

“…Acute lung injury (ALI) remains a serious health issue with little improvement in our understanding of the pathophysiology and therapeutic approaches. We…”
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Detection of fungal particles by Dectin-1 triggers reorganization of macrophage membrane proteins to form a “phagocytic synapse” (134.35) by Goodridge, Helen S, Wawrowsky, Kolja A, Reyes, Christopher N, Ma, Jun, Wolf, Andrea J, Becker, Courtney A, Vasilakos, John P, Underhill, David M

“…Abstract The β-glucan receptor Dectin-1 is a central player in the anti-fungal responses of myeloid phagocytes. Detection of β-glucan-containing particles by…”
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Automated Quantification of DNA Demethylation Effects in Cells via 3D Mapping of Nuclear Signatures and Population Homogeneity Assessment1 by Gertych, Arkadiusz, Wawrowsky, Kolja A., Lindsley, Erik, Vishnevsky, Eugene, Farkas, Daniel L., Tajbakhsh, Jian

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Temozolomide Delivery to Tumor Cells by a Multifunctional Nano Vehicle Based on Poly(β-L-malic acid) : Multifunctional Polymeric Carriers for Gene and Drug Delivery by PATIL, Rameshwar, PORTILLA-ARIAS, José, LJUBIMOVA, Julia Y, HUI DING, INOUE, Satoshi, KONDA, Bindu, JINWEI HU, WAWROWSKY, Kolja A, SHIN, Paul K, BLACK, Keith L, HOLLER, Eggehard

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Fatty acid translocase is localized on insulin-containing granules in human pancreatic [beta]-cells and mediates fatty acid effects on insulin secretion by Noushmehr, Houtan, D'Amico, Eugenio, Farilla, Loredana, Hui, Hongxiang, Wawrowsky, Kolja A, Mlynarski, Wojciech, Doria, Alessandro, Abumrad, Nada A, Perfetti, Riccardo

“…The membrane receptor FAT/CD36 facilitates the major fraction of long-chain fatty acid (FA) uptake by muscle and adipose tissues. In line with the well-known…”
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