Search Results - "Wawrousek, E F"

Single-strand DNA-mediated targeted mutagenesis of genomic DNA in early mouse embryos is stimulated by Rad51 54 and by Ku70 86 inhibition by Morozov, V, Wawrousek, E F

“…Low and variable efficiency is a major problem in targeted gene alteration, which is used as a primary tool in gene therapy and animal model studies. We tested…”
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suppressive oligodeoxynucleotide inhibits ocular inflammation by Fujimoto, C, Klinman, D.M, Shi, G, Yin, H, Vistica, B.P, Lovaas, J.D, Wawrousek, E.F, Igarashi, T, Chan, C.-C, Gery, I

“…Synthetic oligodeoxynucleotides (ODN) expressing 'suppressive' TTAGGG motifs down-regulate a variety of proinflammatory and T helper type 1 (Th1)-mediated…”
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Expression of the murine alpha B-crystallin gene is not restricted to the lens by DUBIN, R. A, WAWROUSEK, E. F, PLATIGORSKY, J

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Lens epithelial cells derived from αB‐crystallin knockout mice demonstrate hyperproliferation and genomic instability by ANDLEY, U.P., SONG, Z., WAWROUSEK, E.F., BRADY, J.P., BASSNETT, S., FLEMING, T.P.

“…ABSTRACT B‐crystallin is a member of the small heat shock protein family and can act as a molecular chaperone preventing the in vitro aggregation of other…”
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Gene Sharing by δ -Crystallin and Argininosuccinate Lyase by Piatigorsky, Joram, O'Brien, William E., Norman, Barbara L., Kalumuck, Karen, Wistow, Graeme J., Borras, Teresa, Nickerson, John M., Wawrousek, Eric F.

“…The lens structural protein δ -crystallin and the metabolic enzyme argininosuccinate lyase (ASL; L-argininosuccinate arginine-lyase, EC 4.3.2.1) have striking…”
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A novel inflammatory eye disease induced by lymphocytes from knockout mice sensitized against the deleted ocular antigen by GELDERMAN, M. P., CHARUKAMNOETKANOK, P., BRADY, J. P., HUNG, L., ZIGLER, J.S., WAWROUSEK, E. F., VISTICA, B. P., FORTIN, E., CHAN, C‐C., GERY, I.

“…SUMMARY Lens‐associated uveitis (LAU), a severe inflammatory eye disease, is thought to be mediated by autoimmunity against lens crystallins. Previously…”
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Expression of the murine alpha B-crystallin gene in lens and skeletal muscle: identification of a muscle-preferred enhancer by DUBIN, R. A, GOPAL-SRIVASTAVA, R, WAWROUSEK, E. F, PIATIGORSKY, J

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Ischemia-induced increase of stiffness of αB-crystallin/HSPB2-deficient myocardium by Golenhofen, N., Redel, A., Wawrousek, E. F., Drenckhahn, D.

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Immunotolerance against a foreign antigen transgenically expressed in the lens by Lai, JC, Fukushima, A, Wawrousek, EF, Lobanoff, MC, Charukamnoetkanok, P, Smith- Gill, SJ, Vistica, BP, Lee, RS, Egwuagu, CE, Whitcup, SM, Gery, I

“…To extend our knowledge concerning immunotolerance against autologous lens crystallins, transgenic (Tg) mice that express a foreign antigen in their lens were…”
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Tissue-specific expression of the chicken alpha A-crystallin gene in cultured lens epithelia and transgenic mice by KLEMENT, J. F, WAWROUSEK, E. F, PIATIGORSKY, J

“…The present experiments show that the single gene for the lens-specific protein alpha A-crystallin of chickens and mice uses a different subset of cis- and…”
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Uveitis Induced by Lymphocytes Sensitized against a Transgenically Expressed Lens Protein by Lai, James C, Lobanoff, Mark C, Fukushima, Atsuki, Wawrousek, Eric F, Chan, Chi-Chao, Whitcup, Scott M, Gery, Igal

“…Previously established experimental models for lens-associated uveitis (LAU) are all mediated by antibodies. The present study analyzed the features of a novel…”
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The transcription factor, Kid-1, is highly expressed in both eye and kidney of the mouse by BRADY, J. P, DUNCAN, M. K, WAWROUSEK, E. F, PIATIGORSKY, J

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Inflammatory Mediators in Uveitis: Differential Induction of Cytokines and Chemokines in Th1- Versus Th2-Mediated Ocular Inflammation by Foxman, Ellen F, Zhang, Meifen, Hurst, Stephen D, Muchamuel, Tony, Shen, Defen, Wawrousek, Eric F, Chan, Chi-Chao, Gery, Igal

“…Ocular inflammation leads to vision loss through the destruction and scarring of delicate tissues along the visual axis. To identify inflammatory mediators…”
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Targeted Disruption of the Mouse α A-crystallin Gene Induces Cataract and Cytoplasmic Inclusion Bodies Containing the Small Heat Shock Protein α B-crystallin by Brady, James P., Garland, Donita, Duglas-Tabor, Yvonne, Robinson, W. Gerald, Groome, Anne, Wawrousek, Eric F.

“…α A-crystallin (α A) and α B-crystallin (α B) are among the predominant proteins of the vertebrate eye lens. In vitro, the α -crystallins, which are isolated…”
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The Molecular Chaperone αA-Crystallin Enhances Lens Epithelial Cell Growth and Resistance to UVA Stress by Andley, Usha P., Song, Zheng, Wawrousek, Eric F., Bassnett, Steven

“…αA-Crystallin (αA) is a member of the small heat shock protein (sHSP) family and has the ability to prevent denatured proteins from aggregating in vitro. Lens…”
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Both PCE-1/RX and OTX/CRX Interactions Are Necessary for Photoreceptor-specific Gene Expression by Kimura, Aira, Singh, Dhirendra, Wawrousek, Eric F., Kikuchi, Masashi, Nakamura, Makoto, Shinohara, Toshimichi

“…RX, a homeodomain-containing protein essential for proper eye development (Mathers, P. H. Grinberg, A., Mahon, K. A., and Jamrich, M. (1997) Nature 387,…”
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Hyperproliferation and p53 Status of Lens Epithelial Cells Derived from αB-crystallin Knockout Mice by Bai, Fang, Xi, Jing Hua, Wawrousek, Eric F., Fleming, Timothy P., Andley, Usha P.

“…αB-Crystallin, a major protein of lens fiber cells, is a stress-induced chaperone expressed at low levels in the lens epithelium and numerous other tissues,…”
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Transketolase Haploinsufficiency Reduces Adipose Tissue and Female Fertility in Mice by Xu, Zheng-Ping, Wawrousek, Eric F., Piatigorsky, Joram

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Two large clusters with thirty-seven transfer RNA genes adjacent to ribosomal RNA gene sets in Bacillus subtilis. Sequence and organization of trrnD and trrnE gene clusters by Wawrousek, E F, Narasimhan, N, Hansen, J N

“…Sequences of two large tRNA gene clusters (trrnD and trrnE) in Bacillus subtilis 168 revealed 16 and 21 tRNA genes, respectively, as identified by anticodon…”
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Structurally Normal Corneas in Aldehyde Dehydrogenase 3a1-Deficient Mice by Nees, David W., Wawrousek, Eric F., Robison, W. Gerald, Piatigorsky, Joram

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