Search Results - "Watts, Russell"

Roles of Acyl-CoA: Diacylglycerol Acyltransferases 1 and 2 in Triacylglycerol Synthesis and Secretion in Primary Hepatocytes by Li, Chen, Li, Lena, Lian, Jihong, Watts, Russell, Nelson, Randal, Goodwin, Bryan, Lehner, Richard

“…OBJECTIVE—Very low–density lipoprotein assembly and secretion are regulated by the availability of triacylglycerol. Although compelling evidence indicates that…”
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Carboxylesterase 1d (Ces1d) does not contribute to cholesteryl ester hydrolysis in the liver by Lian, Jihong, van der Veen, Jelske N., Watts, Russell, Jacobs, René L., Lehner, Richard

“…The liver is the central organ regulating cholesterol synthesis, storage, transport, and elimination. Mouse carboxylesterase 1d (Ces1d) and its human ortholog…”
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Ces1d deficiency protects against high-sucrose diet-induced hepatic triacylglycerol accumulation[S] by Lian, Jihong, Watts, Russell, Quiroga, Ariel D., Beggs, Megan R., Alexander, R. Todd, Lehner, Richard

“…Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Triacylglycerol accumulation in the liver is a hallmark of NAFLD. Metabolic…”
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Absence of Tissue Inhibitor of Metalloproteinase-4 (TIMP4) ameliorates high fat diet-induced obesity in mice due to defective lipid absorption by Sakamuri, Siva S. V. P., Watts, Russell, Takawale, Abhijit, Wang, Xiuhua, Hernandez-Anzaldo, Samuel, Bahitham, Wesam, Fernandez-Patron, Carlos, Lehner, Richard, Kassiri, Zamaneh

“…Tissue inhibitor of metalloproteases (TIMPs) are inhibitors of matrix metalloproteinases (MMPs) that regulate tissue extracellular matrix (ECM) turnover. TIMP4…”
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FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver by Wang, Haizhen, Nikain, Cyrus, Fortounas, Konstantinos I., Amengual, Jaume, Tufanli, Ozlem, La Forest, Maxwell, Yu, Yong, Wang, Meng C., Watts, Russell, Lehner, Richard, Qiu, Yunping, Cai, Min, Kurland, Irwin J., Goldberg, Ira J., Rajan, Sujith, Hussain, M. Mahmood, Brodsky, Jeffrey L., Fisher, Edward A.

“…Triglycerides (TGs) associate with apolipoprotein B100 (apoB100) to form very low density lipoproteins (VLDLs) in the liver. The repertoire of factors that…”
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Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice by MacDonald, Marcia L.E., Singaraja, Roshni R., Bissada, Nagat, Ruddle, Piers, Watts, Russell, Karasinska, Joanna M., Gibson, William T., Fievet, Catherine, Vance, Jean E., Staels, Bart, Hayden, Michael R.

“…A combination of the interrelated metabolic risk factors obesity, insulin resistance, dyslipidemia, and hypertension, often described as the “metabolic…”
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Marginalized Males? Men, Masculinity and Catherine Breillat by Russell-Watts, Lynsey

“…Catherine Breillat's films are generally assumed to have as their central concerns women, female subjectivity and female sexuality. Men in Breillat's films…”
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When Life Is Too Long To Test: Combining Multiple Methods To Minimize Risk by Watts, Russell

“…Summary & ConclusionsLonger life expectations and greater amounts of usage during that lifetime pose significant challenges to traditional methods of…”
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Streamlined & Results Oriented Adaptation Of The DFMEA Process by Watts, Russell

“…This paper presents a flexible alteration to typical FMEA methodology that may cut typical FMEA completion time by as much as ½ while simultaneously increasing…”
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Preferential lipolysis of DGAT1 over DGAT2 generated triacylglycerol in Huh7 hepatocytes by Selvaraj, Rajakumar, Zehnder, Sarah V., Watts, Russell, Lian, Jihong, Das, Chinmayee, Nelson, Randal, Lehner, Richard

“…Two distinct diacylglycerol acyltransferases (DGAT1 and DGAT2) catalyze the final committed step of triacylglycerol (TG) synthesis in hepatocytes. After its…”
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Liver-specific expression of carboxylesterase 1g/esterase-x reduces hepatic steatosis, counteracts dyslipidemia and improves insulin signaling by Bahitham, Wesam, Watts, Russell, Nelson, Randal, Lian, Jihong, Lehner, Richard

“…Ces1g/Es-x deficiency in mice results in weight gain, insulin resistance, fatty liver and hyperlipidemia through upregulation of de novo lipogenesis and…”
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Attenuation of obesity-induced hyperlipidemia reduces tumor growth by Hussain, Aashiq, Lian, Jihong, Watts, Russell, Gutiérrez, Tomás, Nelson, Randal, Goping, Ing Swie, Lehner, Richard

“…Accumulating evidence suggests that hyperlipidemia is associated with obesity and cancer mortality in humans. We tested the hypotheses that inhibition of…”
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Ero1α requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM) by Gilady, Susanna Y., Bui, Michael, Lynes, Emily M., Benson, Matthew D., Watts, Russell, Vance, Jean E., Simmen, Thomas

“…Protein secretion from the endoplasmic reticulum (ER) requires the enzymatic activity of chaperones and oxidoreductases that fold polypeptides and form…”
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Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis by Lian, Jihong, Bahitham, Wesam, Panigrahi, Rashmi, Nelson, Randal, Li, Lena, Watts, Russell, Thiesen, Aducio, Lemieux, M. Joanne, Lehner, Richard

“…Obesity often leads non-alcoholic fatty liver disease, insulin resistance and hyperlipidemia. Expression of carboxylesterase CES1 is positively correlated with…”
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Ces3/TGH Deficiency Attenuates Steatohepatitis by Lian, Jihong, Wei, Enhui, Groenendyk, Jody, Das, Subhash K., Hermansson, Martin, Li, Lena, Watts, Russell, Thiesen, Aducio, Oudit, Gavin Y., Michalak, Marek, Lehner, Richard

“…Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in developed countries. NAFLD describes a wide range of liver…”
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Catherine Breillat's "Romance" and the Female Spectator: From Dream-Work to Therapy by Hottell, Ruth A., Russell-Watts, Lynsey

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SUN-019 Androgens Modulate Lipid Metabolism and Absorption in Control and Polycystic Ovary-Metabolic Syndrome Conditions by Vine, Donna Faye, Lehner, Richard, Watts, Russell, Horkey, Melanie, Ghosh, Mahua, Proctor, Spencer

“…Introduction: In polycystic ovary syndrome (PCOS) a high plasma level of androgens has been correlated with an adverse plasma lipid profile. At present we do…”
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Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation by Lord, Caleb C., Ferguson, Daniel, Thomas, Gwynneth, Brown, Amanda L., Schugar, Rebecca C., Burrows, Amy, Gromovsky, Anthony D., Betters, Jenna, Neumann, Chase, Sacks, Jessica, Marshall, Stephanie, Watts, Russell, Schweiger, Martina, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Lathia, Justin D., Sakaguchi, Takuya F., Lehner, Richard, Haemmerle, Guenter, Zechner, Rudolf, Brown, J. Mark

“…Adipose triglyceride lipase (ATGL) and comparative gene identification 58 (CGI-58) are critical regulators of triacylglycerol (TAG) turnover. CGI-58 is thought…”
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Nerve growth factor acts through the TrkA receptor to protect sensory neurons from the damaging effects of the HIV-1 viral protein, Vpr by Webber, C.A, Salame, J, Luu, G.-L.S, Acharjee, S, Ruangkittisakul, A, Martinez, J.A, Jalali, H, Watts, R, Ballanyi, K, Guo, G.F, Zochodne, D.W, Power, C

“…Highlights • Viral protein R (Vpr) causes neuropathic pain and footpad denervation in vivo. • Vpr increases cytosolic calcium in sensory neurons and decreases…”
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Introduction by Rushton, Richard, Russell-Watts, Lynsey

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