Search Results - "Watts, Felicity Z."

Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair by Lu, Wei-Ting, Hawley, Ben R., Skalka, George L., Baldock, Robert A., Smith, Ewan M., Bader, Aldo S., Malewicz, Michal, Watts, Felicity Z., Wilczynska, Ania, Bushell, Martin

“…The error-free and efficient repair of DNA double-stranded breaks (DSBs) is extremely important for cell survival. RNA has been implicated in the resolution of…”
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ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX by Baldock, Robert A., Day, Matthew, Wilkinson, Oliver J., Cloney, Ross, Jeggo, Penelope A., Oliver, Antony W., Watts, Felicity Z., Pearl, Laurence H.

“…53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin…”
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Sumoylation of eIF4A2 affects stress granule formation by Jongjitwimol, Jirapas, Baldock, Robert A, Morley, Simon J, Watts, Felicity Z

“…Regulation of protein synthesis is crucial for cells to maintain viability and to prevent unscheduled proliferation that could lead to tumorigenesis. Exposure…”
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Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint by Bigot, Nicolas, Day, Matthew, Baldock, Robert A, Watts, Felicity Z, Oliver, Antony W, Pearl, Laurence H

“…Coordination of the cellular response to DNA damage is organised by multi-domain 'scaffold' proteins, including 53BP1 and TOPBP1, which recognise…”
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Repair of DNA Double-Strand Breaks in Heterochromatin by Watts, Felicity Z

“…DNA double-strand breaks (DSBs) are among the most damaging lesions in DNA, since, if not identified and repaired, they can lead to insertions, deletions or…”
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SUMO meets meiosis: An encounter at the synaptonemal complex by Watts, Felicity Z., Hoffmann, Eva

“…Recent discoveries have identified the small ubiquitin‐like modifier (SUMO) as the potential ‘missing link’ that could explain how the synaptonemal complex…”
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Nse2, a Component of the Smc5-6 Complex, Is a SUMO Ligase Required for the Response to DNA Damage by Andrews, Emily A., Palecek, Jan, Sergeant, John, Taylor, Elaine, Lehmann, Alan R., Watts, Felicity Z.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2 by Jongjitwimol, Jirapas, Feng, Min, Zhou, Lihong, Wilkinson, Oliver, Small, Lauren, Baldock, Robert, Taylor, Deborah L, Smith, Duncan, Bowler, Lucas D, Morley, Simon J, Watts, Felicity Z

“…SUMO is a small post-translational modifier, that is attached to lysine residues in target proteins. It acts by altering protein-protein interactions, protein…”
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Composition and Architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) Complex by Sergeant, John, Taylor, Elaine, Palecek, Jan, Fousteri, Maria, Andrews, Emily A., Sweeney, Sara, Shinagawa, Hideo, Watts, Felicity Z., Lehmann, Alan R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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SUMO Chain Formation Is Required for Response to Replication Arrest in S. pombe by Skilton, Andrew, Ho, Jenny C.Y, Mercer, Brenda, Outwin, Emily, Watts, Felicity Z

“…SUMO is a ubiquitin-like protein that is post-translationally attached to one or more lysine residues on target proteins. Despite having only 18% sequence…”
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SUMOylation is required for normal development of linear elements and wild-type meiotic recombination in Schizosaccharomyces pombe by Spirek, Mario, Estreicher, Anna, Csaszar, Edina, Wells, Jennifer, McFarlane, Ramsay J, Watts, Felicity Z, Loidl, Josef

“…In the fission yeast, Schizosaccharomyces pombe, synaptonemal complexes (SCs) are not formed during meiotic prophase. However, structures resembling the axial…”
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SUMO Modification Is Involved in the Maintenance of Heterochromatin Stability in Fission Yeast by Shin, Jin A., Choi, Eun Shik, Kim, Hyun Soo, Ho, Jenny C.Y., Watts, Felicity Z., Park, Sang Dai, Jang, Yeun Kyu

“…Several studies have suggested that SUMO may participate in the regulation of heterochromatin, but direct evidence is lacking. Here, we present a direct link…”
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Starting and stopping SUMOylation: What regulates the regulator? by Watts, Felicity Z.

“…A large number of proteins are modified post-translationally by the ubiquitin-like protein (Ubl) SUMO. This process, known as sumoylation, regulates the…”
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Characterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60 by Boyd, Lara K, Mercer, Brenda, Thompson, Darren, Main, Ewan, Watts, Felicity Z

“…The S. pombe Rad60 protein is required for the repair of DNA double strand breaks, recovery from replication arrest, and is essential for cell viability. It…”
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Nep1, a Schizosaccharomyces pombe deneddylating enzyme by Zhou, Lihong, Watts, Felicity Z

“…Nedd8 is a ubiquitin-like modifier that is attached to the cullin components of E3 ubiquitin ligases. More recently, p53 has also been shown to be…”
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SUMO meets meiosis: An encounter at the synaptonemal complex: SUMO chains and sumoylated proteins suggest that heterogeneous and complex interactions lie at the centre of the synaptonemal complex by Watts, Felicity Z, Hoffmann, Eva

“…Recent discoveries have identified the small ubiquitin-like modifier (SUMO) as the potential ‘missing link' that could explain how the synaptonemal complex…”
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Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection by Densham, Ruth M, Garvin, Alexander J, Stone, Helen R, Strachan, Joanna, Baldock, Robert A, Daza-Martin, Manuel, Fletcher, Alice, Blair-Reid, Sarah, Beesley, James, Johal, Balraj, Pearl, Laurence H, Neely, Robert, Keep, Nicholas H, Watts, Felicity Z, Morris, Joanna R

“…The E3 ubiquitin ligase activity of the BRCA1–BARD1 complex is required to reposition 53BP1 on damaged chromatin and to promote DNA resection and repair via…”
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role of SUMO in chromosome segregation by Watts, Felicity Z

“…Chromosome segregation is an essential feature of the eukaryotic cell cycle. Efficient chromosome segregation requires the co-ordination of several cellular…”
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Postreplication repair and PCNA modification in Schizosaccharomyces pombe by Frampton, Jonathan, Irmisch, Anja, Green, Catherine M, Neiss, Andrea, Trickey, Michelle, Ulrich, Helle D, Furuya, Kanji, Watts, Felicity Z, Carr, Antony M, Lehmann, Alan R

“…Ubiquitination of proliferating cell nuclear antigen (PCNA) plays a crucial role in regulating replication past DNA damage in eukaryotes, but the detailed…”
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Sumoylation of PCNA: Wrestling with recombination at stalled replication forks by Watts, Felicity Z.

“…Post-replication repair encompassses error-prone and error-free processes for bypassing lesions encountered during DNA replication. In Saccharomyces…”
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