Search Results - "Watts, Clarissa J."

Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H1 receptor antagonists for use in allergic rhinitis by Procopiou, Panayiotis A., Ford, Alison J., Gore, Paul M., Hancock, Ashley P., Hodgson, Simon T., Holmes, Duncan S., Looker, Brian E., Vile, Sadie, Clark, Kenneth L., Saunders, Ken A., Slack, Robert J., Watts, Clarissa J.

“…Selective human H1 histamine receptor antagonist pA2=9.3 with 24h duration of action. [Display omitted] A series of potent, selective and long-acting…”
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Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H 1 receptor antagonists for use in allergic rhinitis by Procopiou, Panayiotis A, Ford, Alison J, Gore, Paul M, Hancock, Ashley P, Hodgson, Simon T, Holmes, Duncan S, Looker, Brian E, Vile, Sadie, Clark, Kenneth L, Saunders, Ken A, Slack, Robert J, Watts, Clarissa J

“…A series of potent, selective and long-acting quinoline-based sulfonamide human H histamine receptor antagonists, designed for once-daily intranasal…”
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Design of Phthalazinone Amide Histamine H 1 Receptor Antagonists for Use in Rhinitis by Procopiou, Panayiotis A, Ford, Alison J, Gore, Paul M, Looker, Brian E, Hodgson, Simon T, Holmes, Duncan S, Vile, Sadie, Clark, Kenneth L, Saunders, Ken A, Slack, Robert J, Rowedder, James E, Watts, Clarissa J

“…The synthesis of potent amide-containing phthalazinone H histamine receptor antagonists is described. Three analogues , , and were equipotent with azelastine…”
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Iκ-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma by BIRRELL, Mark A, HARDAKER, Elizabeth, SHAW, Robert J, SAVAGE, Tony J, BELVISI, Maria G, WONG, Sissie, MCCLUSKIE, Kerryn, CATLEY, Matthew, DE ALBA, Jorge, NEWTON, Robert, HAJ-YAHIA, Saleem, TAO PUN, K, WATTS, Clarissa J

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Design of Phthalazinone Amide Histamine H1 Receptor Antagonists for Use in Rhinitis by Procopiou, Panayiotis A, Ford, Alison J, Gore, Paul M, Looker, Brian E, Hodgson, Simon T, Holmes, Duncan S, Vile, Sadie, Clark, Kenneth L, Saunders, Ken A, Slack, Robert J, Rowedder, James E, Watts, Clarissa J

“…The synthesis of potent amide-containing phthalazinone H1 histamine receptor antagonists is described. Three analogues 3e, 3g, and 9g were equipotent with…”
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The Discovery of Phthalazinone-Based Human H1 and H3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis by Procopiou, Panayiotis A, Browning, Christopher, Buckley, Jennifer M, Clark, Kenneth L, Fechner, Lise, Gore, Paul M, Hancock, Ashley P, Hodgson, Simon T, Holmes, Duncan S, Kranz, Michael, Looker, Brian E, Morriss, Karen M. L, Parton, Daniel L, Russell, Linda J, Slack, Robert J, Sollis, Steven L, Vile, Sadie, Watts, Clarissa J

“…A series of potent phthalazinone-based human H1 and H3 bivalent histamine receptor antagonists, suitable for intranasal administration for the potential…”
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4-Acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a Novel Class of Non-Brain-Penetrant Histamine H3 Receptor Antagonists by Procopiou, Panayiotis A, Ancliff, Rachael A, Bamford, Mark J, Browning, Christopher, Connor, Helen, Davies, Susannah, Fogden, Yvonne C, Hodgson, Simon T, Holmes, Duncan S, Looker, Brian E, Morriss, Karen M. L, Parr, Christopher A, Pickup, Elizabeth A, Sehmi, Sanjeet S, White, Gemma V, Watts, Clarissa J, Wilson, David M, Woodrow, Michael D

“…A series of ketopiperazines were prepared and evaluated for their activity as histamine H3 antagonists. From investigation of the tertiary basic center in the…”
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The Discovery of Phthalazinone-Based Human H 1 and H 3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis by Procopiou, Panayiotis A., Browning, Christopher, Buckley, Jennifer M., Clark, Kenneth L., Fechner, Lise, Gore, Paul M., Hancock, Ashley P., Hodgson, Simon T., Holmes, Duncan S., Kranz, Michael, Looker, Brian E., Morriss, Karen M. L., Parton, Daniel L., Russell, Linda J., Slack, Robert J., Sollis, Steven L., Vile, Sadie, Watts, Clarissa J.

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4-Acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a Novel Class of Non-Brain-Penetrant Histamine H 3 Receptor Antagonists by Procopiou, Panayiotis A., Ancliff, Rachael A., Bamford, Mark J., Browning, Christopher, Connor, Helen, Davies, Susannah, Fogden, Yvonne C., Hodgson, Simon T., Holmes, Duncan S., Looker, Brian E., Morriss, Karen M. L., Parr, Christopher A., Pickup, Elizabeth A., Sehmi, Sanjeet S., White, Gemma V., Watts, Clarissa J., Wilson, David M., Woodrow, Michael D.

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I{kappa}-B Kinase-2 Inhibitor Blocks Inflammation in Human Airway Smooth Muscle and a Rat Model of Asthma by Birrell, Mark A, Hardaker, Elizabeth, Wong, Sissie, McCluskie, Kerryn, Catley, Matthew, De Alba, Jorge, Newton, Robert, Haj-Yahia, Saleem, Pun, K. Tao, Watts, Clarissa J, Shaw, Robert J, Savage, Tony J, Belvisi, Maria G

“…Nuclear factor (NF)-kappaB is a transcription factor known to regulate the expression of many inflammatory genes, including cytokines, chemokines, and adhesion…”
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Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma by Birrell, Mark A, Hardaker, Elizabeth, Wong, Sissie, McCluskie, Kerryn, Catley, Matthew, De Alba, Jorge, Newton, Robert, Haj-Yahia, Saleem, Pun, K Tao, Watts, Clarissa J, Shaw, Robert J, Savage, Tony J, Belvisi, Maria G

“…Nuclear factor (NF)-kappaB is a transcription factor known to regulate the expression of many inflammatory genes, including cytokines, chemokines, and adhesion…”
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