Search Results - "Watters, J."

Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice by Crain, Jessica M., Nikodemova, Maria, Watters, Jyoti J.

“…Although microglial activation is associated with all CNS disorders, many of which are sexually dimorphic or age‐dependent, little is known about whether…”
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Transcriptional response of murine microglia in Alzheimer's disease and inflammation by Shippy, Daniel C, Watters, Jyoti J, Ulland, Tyler K

“…Alzheimer's disease (AD) is a neurodegenerative disorder and is the most common cause of late-onset dementia. Microglia, the primary innate immune cells of the…”
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Efficient isolation of live microglia with preserved phenotypes from adult mouse brain by Nikodemova, Maria, Watters, Jyoti J

“…Microglial activation plays a key role in the neuroinflammation associated with virtually all CNS disorders, although their role in normal CNS physiology is…”
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A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring by Vanderplow, Amanda M, Kermath, Bailey A, Bernhardt, Cassandra R, Gums, Kimberly T, Seablom, Erin N, Radcliff, Abigail B, Ewald, Andrea C, Jones, Mathew V, Baker, Tracy L, Watters, Jyoti J, Cahill, Michael E

“…Mounting epidemiologic and scientific evidence indicates that many psychiatric disorders originate from a complex interplay between genetics and early life…”
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Secondary school principals as change agents in Kuwait : Principals' perspectives by Alsharija, Mohammed, Watters, James J

“…Kuwait is seeking to diversify its sources of income by modernizing the education system and providing its young people with the knowledge and skills needed…”
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Chronic intermittent hypoxia exerts CNS region-specific effects on rat microglial inflammatory and TLR4 gene expression by Smith, Stephanie M C, Friedle, Scott A, Watters, Jyoti J

“…Intermittent hypoxia (IH) during sleep is a hallmark of sleep apnea, causing significant neuronal apoptosis, and cognitive and behavioral deficits in CNS…”
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Obstructive Sleep Apnea-Associated Intermittent Hypoxia-Induced Immune Responses in Males, Pregnancies, and Offspring by Song, Ruolin, Baker, Tracy L, Watters, Jyoti J, Kumar, Sathish

“…Obstructive sleep apnea (OSA), a respiratory sleep disorder associated with cardiovascular diseases, is more prevalent in men. However, OSA occurrence in…”
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Silent hypoxaemia in COVID‐19 patients by Simonson, Tatum S., Baker, Tracy L., Banzett, Robert B., Bishop, Tammie, Dempsey, Jerome A., Feldman, Jack L., Guyenet, Patrice G., Hodson, Emma J., Mitchell, Gordon S., Moya, Esteban A., Nokes, Brandon T., Orr, Jeremy E., Owens, Robert L., Poulin, Marc, Rawling, Jean M., Schmickl, Christopher N., Watters, Jyoti J., Younes, Magdy, Malhotra, Atul

“…The clinical presentation of COVID‐19 due to infection with SARS‐CoV‐2 is highly variable with the majority of patients having mild symptoms while others…”
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Microglial numbers attain adult levels after undergoing a rapid decrease in cell number in the third postnatal week by Nikodemova, Maria, Kimyon, Rebecca S, De, Ishani, Small, Alissa L, Collier, Lara S, Watters, Jyoti J

“…Abstract During postnatal development, microglia, CNS resident innate immune cells, are essential for synaptic pruning, neuronal apoptosis and remodeling…”
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Systemic LPS induces spinal inflammatory gene expression and impairs phrenic long-term facilitation following acute intermittent hypoxia by Huxtable, A G, Smith, S M C, Vinit, S, Watters, J J, Mitchell, G S

“…Although systemic inflammation occurs in most pathological conditions that challenge the neural control of breathing, little is known concerning the impact of…”
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Mechanisms of microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia by Kiernan, Elizabeth A., Smith, Stephanie M. C., Mitchell, Gordon S., Watters, Jyoti J.

“…Chronic intermittent hypoxia (CIH) is a hallmark of sleep apnoea, a condition associated with diverse clinical disorders. CIH and sleep apnoea are…”
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Sensitive Detection of Mono- and Polyclonal ESR1 Mutations in Primary Tumors, Metastatic Lesions, and Cell-Free DNA of Breast Cancer Patients by Wang, Peilu, Bahreini, Amir, Gyanchandani, Rekha, Lucas, Peter C, Hartmaier, Ryan J, Watters, Rebecca J, Jonnalagadda, Amruth R, Trejo Bittar, Humberto E, Berg, Aaron, Hamilton, Ronald L, Kurland, Brenda F, Weiss, Kurt R, Mathew, Aju, Leone, Jose Pablo, Davidson, Nancy E, Nikiforova, Marina N, Brufsky, Adam M, Ambros, Tadeu F, Stern, Andrew M, Puhalla, Shannon L, Lee, Adrian V, Oesterreich, Steffi

“…Given the clinical relevance of ESR1 mutations as potential drivers of resistance to endocrine therapy, this study used sensitive detection methods to…”
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Microglia function in brain tumors by Watters, Jyoti J., Schartner, Jill M., Badie, Behnam

“…Microglia play an important role in inflammatory diseases of the central nervous system (CNS). These cells have also been identified in brain neoplasms;…”
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Outbred ICR/CD1 mice display more severe neuroinflammation mediated by microglial TLR4/CD14 activation than inbred C57Bl/6 mice by Nikodemova, M, Watters, J.J

“…Abstract Neuroinflammation mediated by microglia is a pathological hallmark of many CNS disorders. Cell lines derived from inbred C57Bl/6 and outbred ICR/CD1…”
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Acute postnatal inflammation alters adult microglial responses to LPS that are sex-, region- and timing of postnatal inflammation-dependent by Nikodemova, Maria, Oberto, Jose R, Kaye, Ethan L, Berschel, Mackenzie R, Michaelson, Alysha L, Watters, Jyoti J, Mitchell, Gordon S

“…Adverse events in early life can have impact lasting into adulthood. We investigated the long-term effects of systemic inflammation during postnatal…”
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Intermittent Hypoxia-Induced Spinal Inflammation Impairs Respiratory Motor Plasticity by a Spinal p38 MAP Kinase-Dependent Mechanism by Huxtable, Adrianne G, Smith, Stephanie M C, Peterson, Timothy J, Watters, Jyoti J, Mitchell, Gordon S

“…Inflammation is characteristic of most clinical disorders that challenge the neural control of breathing. Since inflammation modulates neuroplasticity, we…”
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Ferritin functions as a proinflammatory cytokine via iron‐independent protein kinase C zeta/nuclear factor kappaB–regulated signaling in rat hepatic stellate cells by Ruddell, Richard G., Hoang‐Le, Diem, Barwood, Joanne M., Rutherford, Paul S., Piva, Terrance J., Watters, Dianne J., Santambrogio, Paolo, Arosio, Paolo, Ramm, Grant A.

“…Circulating ferritin levels reflect body iron stores and are elevated with inflammation in chronic liver injury. H‐ferritin exhibits a number of extrahepatic…”
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Gestational intermittent hypoxia increases FosB‐immunoreactive perikaryas in the paraventricular nucleus of the hypothalamus of adult male (but not female) rats by Ambrozio‐Marques, Danuzia, Gagnon, Marianne, Radcliff, Abigail B., Meza, Armand L., Baker, Tracy L., Watters, Jyoti J., Kinkead, Richard

“…Sleep‐disordered breathing is a respiratory disorder commonly experienced by pregnant women. The recurrent hypoxaemic events associated with sleep‐disordered…”
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Sex- and Region-Specific Differences in the Transcriptomes of Rat Microglia from the Brainstem and Cervical Spinal Cord by Ewald, Andrea C, Kiernan, Elizabeth A, Roopra, Avtar S, Radcliff, Abigail B, Timko, Rebecca R, Baker, Tracy L, Watters, Jyoti J

“…The neural control system underlying breathing is sexually dimorphic with males being more vulnerable to dysfunction. Microglia also display sex differences,…”
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Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats by Nikodemova, Maria, Small, Alissa L, Smith, Stephanie M.C, Mitchell, Gordon S, Watters, Jyoti J

“…Abstract Activation of microglia, CNS resident immune cells, is a pathological hallmark of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder…”
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