Search Results - "Wattchow, David A."

Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine by Sun, Emily W, de Fontgalland, Dayan, Rabbitt, Philippa, Hollington, Paul, Sposato, Luigi, Due, Steven L, Wattchow, David A, Rayner, Christopher K, Deane, Adam M, Young, Richard L, Keating, Damien J

“…Intestinal glucose stimulates secretion of the incretin hormone glucagon-like peptide 1 (GLP-1). The mechanisms underlying this pathway have not been fully…”
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Stimulation of extrinsic sympathetic nerves differentially affects neurogenic motor activity in guinea pig distal colon by Smolilo, David J., Hibberd, Timothy J., Costa, Marcello, Dinning, Phil G., Keightley, Lauren J., De Fontgalland, Dayan, Wattchow, David A., Spencer, Nick J.

“…The speed of pellet propulsion through the isolated guinea pig distal colon in vitro significantly exceeds in vivo measurements, suggesting a role for…”
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Roles of three distinct neurogenic motor patterns during pellet propulsion in guinea‐pig distal colon by Costa, Marcello, Keightley, Lauren J., Wiklendt, Lukasz, Hibberd, Timothy J., Arkwright, John W., Omari, Taher, Wattchow, David A., Zagorodnyuk, Vladimir, Brookes, Simon J. H., Dinning, Phil G., Spencer, Nick J.

“…Key points Enteric neural circuits enable isolated preparations of guinea‐pig distal colon to propel solid and fluid contents by a self‐sustaining…”
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Sympathetic Pathways Target Cholinergic Neurons in the Human Colonic Myenteric Plexus by Parker, Dominic R, Wiklendt, Lukasz, Humenick, Adam, Chen, Bao Nan, Sia, Tiong Cheng, Wattchow, David A, Dinning, Phil G, Brookes, Simon J H

“…The sympathetic nervous system inhibits human colonic motility largely by effects on enteric neurons. Noradrenergic axons, which branch extensively in the…”
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Characterization of viscerofugal neurons in human colon by retrograde tracing and multi-layer immunohistochemistry by Chen, Bao Nan, Humenick, Adam G, Hibberd, Timothy James, Yew, Wai Ping, Wattchow, David A, Dinning, Phil G, Costa, Marcello, Spencer, Nick J, Brookes, Simon J H

“…Viscerofugal neurons (VFNs) have cell bodies in the myenteric plexus and axons that project to sympathetic prevertebral ganglia. In animals they activate…”
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Characterisation of parasympathetic ascending nerves in human colon by Johnson, Michaela E, Humenick, Adam, Peterson, Rochelle A, Costa, Marcello, Wattchow, David A, Sia, Tiong Cheng, Dinning, Phil G, Brookes, Simon J H

“…In the human large bowel, sacral parasympathetic nerves arise from S2 to S4, project to the pelvic plexus ("hypogastric plexus") and have post-ganglionic axons…”
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Characterization of projections of longitudinal muscle motor neurons in human colon by Humenick, Adam, Chen, Bao Nan, Lauder, Chris I. W., Wattchow, David A., Zagorodnyuk, Vladimir P., Dinning, Phil G., Spencer, Nick J., Costa, Marcello, Brookes, Simon J. H.

“…Background The enteric nervous system contains inhibitory and excitatory motor neurons which modulate smooth muscle contractility. Cell bodies of longitudinal…”
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Efficacy and safety of low-dose celecoxib in reducing post-operative paralytic ileus after major abdominal surgery by Raju, Devinder P., Hakendorf, Paul, Costa, Marcello, Wattchow, David A.

“…Background A number of interventions have been used to decrease the incidence of post‐operative paralytic ileus. A secondary outcome of a randomized controlled…”
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Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice by Spencer, Nick J., Travis, Lee, Wiklendt, Lukasz, Costa, Marcello, Hibberd, Timothy J., Brookes, Simon J., Dinning, Phil, Hu, Hongzhen, Wattchow, David A., Sorensen, Julian

“…How the Enteric Nervous System (ENS) coordinates propulsion of content along the gastrointestinal (GI)-tract has been a major unresolved issue. We reveal a…”
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Sugar Responses of Human Enterochromaffin Cells Depend on Gut Region, Sex, and Body Mass by Lumsden, Amanda L, Martin, Alyce M, Sun, Emily W, Schober, Gudrun, Isaacs, Nicole J, Pezos, Nektaria, Wattchow, David A, de Fontgalland, Dayan, Rabbitt, Philippa, Hollington, Paul, Sposato, Luigi, Due, Steven L, Rayner, Christopher K, Nguyen, Nam Q, Liou, Alice P, Jackson, V Margaret, Young, Richard L, Keating, Damien J

“…Gut-derived serotonin (5-HT) is released from enterochromaffin (EC) cells in response to nutrient cues, and acts to slow gastric emptying and modulate gastric…”
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5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT by Sia, Tiong C, Whiting, Malcolm, Kyloh, Melinda, Nicholas, Sarah J, Oliver, John, Brookes, Simon J, Dinning, Phil G, Wattchow, David A, Spencer, Nick J

“…Recent studies have shown that endogenous serotonin is not required for colonic peristalsis in vitro, nor gastrointestinal (GI) transit in vivo. However,…”
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Damage from dissection is associated with reduced neuro-musclar transmission and gap junction coupling between circular muscle cells of guinea pig ileum, in vitro by Carbone, Simona E, Wattchow, David A, Spencer, Nick J, Hibberd, Timothy J, Brookes, Simon J H

“…Excitatory and inhibitory junction potentials of circular smooth muscle cells in guinea pig ileum and colon are suppressed 30-90 min after setting up in vitro…”
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Identification of a Rhythmic Firing Pattern in the Enteric Nervous System That Generates Rhythmic Electrical Activity in Smooth Muscle by Spencer, Nick J, Hibberd, Timothy J, Travis, Lee, Wiklendt, Lukasz, Costa, Marcello, Hu, Hongzhen, Brookes, Simon J, Wattchow, David A, Dinning, Phil G, Keating, Damien J, Sorensen, Julian

“…The enteric nervous system (ENS) contains millions of neurons essential for organization of motor behavior of the intestine. It is well established that the…”
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Intrinsic sensory neurons provide direct input to motor neurons and interneurons in mouse distal colon via varicose baskets by Smolilo, David J., Hibberd, Timothy J., Costa, Marcello, Wattchow, David A., De Fontgalland, Dayan, Spencer, Nick J.

“…Connections from intrinsic primary afferent neurons (IPANs), to ascending motor and interneurons have been described in guinea pig colon. These mono‐ and…”
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Augmented capacity for peripheral serotonin release in human obesity by Young, Richard L., Lumsden, Amanda L., Martin, Alyce M., Schober, Gudrun, Pezos, Nektaria, Thazhath, Sony S., Isaacs, Nicole J., Cvijanovic, Nada, Sun, Emily W. L., Wu, Tongzhi, Rayner, Christopher K., Nguyen, Nam Q., Fontgalland, Dayan de, Rabbitt, Philippa, Hollington, Paul, Sposato, Luigi, Due, Steven L., Wattchow, David A., Liou, Alice P., Jackson, V. Margaret, Keating, Damien J.

“…Background/objectives Evidence from animal studies highlights an important role for serotonin (5-HT), derived from gut enterochromaffin (EC) cells, in…”
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Electrophysiological and morphological features of myenteric neurons of human colon revealed by intracellular recording and dye fills by Yew, Wai Ping, Humenick, Adam, Chen, Bao Nan, Wattchow, David A., Costa, Marcello, Dinning, Phil G., Brookes, Simon J. H.

“…Background Ex vivo intracellular recordings and dye fills, combined with immunohistochemistry, are a powerful way to analyze the enteric nervous system of…”
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From the organ bath to the whole person: a review of human colonic motility by Wattchow, David A, Brookes, Simon J, Spencer, Nick J, Heitmann, Paul T, De Giorgio, Roberto, Costa, Marcello, Dinning, Phil G

“…Motor function of the colon is essential for health. Our current understanding of the mechanisms that underlie colonic motility are based upon a range of…”
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Circulating cathepsin S improves glycaemic control in mice by Karimkhanloo, Hamzeh, Keenan, Stacey N, Sun, Emily W, Wattchow, David A, Keating, Damien J, Montgomery, Magdalene K, Watt, Matthew J

“…Cathepsin S (CTSS) is a cysteine protease that regulates many physiological processes and is increased in obesity and type 2 diabetes. While previous studies…”
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Dynamin regulates L cell secretion in human gut by Sun, Emily WL, Matusica, Dusan, Wattchow, David A., McCluskey, Adam, Robinson, Philip J., Keating, Damien J.

“…The mechanochemical enzyme dynamin mediates endocytosis and regulates neuroendocrine cell exocytosis. Enteroendocrine L cells co-secrete the anorectic gut…”
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Alterations in GLP-1 and PYY release with aging and body mass in the human gut by Jones, Lauren A., Sun, Emily W., Lumsden, Amanda L., Thorpe, Daniel W., Peterson, Rochelle A., De Fontgalland, Dayan, Sposato, Luigi, Rabbitt, Philippa, Hollington, Paul, Wattchow, David A., Keating, Damien J.

“…The lining of our intestinal surface contains an array of hormone-producing cells that are collectively our bodies’ largest endocrine cell reservoir. These…”
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