Design and Optimization of 3D-Printed Tablets Containing Mucuna Extracts for Erectile Dysfunction Management: A DoE-Guided Study

Design and Optimization of 3D-Printed Tablets Containing Mucuna Extracts for Erectile Dysfunction Management: A DoE-Guided Study

Erectile dysfunction (ED) refers to the inability of the penis to maintain a firm erection during sexual activity. Mucuna, or , contains levodopa, a compound showing promise in ED treatment. However, formulating Mucuna extract into tablet dosage forms is challenging due to its semisolid nature. This...

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Bibliographic Details
Published in:Plants (Basel) Vol. 13; no. 16; p. 2294
Main Authors: Wattanawiggan, Ratchapoom, Chansakaow, Sunee, Jantrawut, Pensak, Panraksa, Pattaraporn, Jiaranaikulwanitch, Jutamas, Udomsom, Suruk, Worajittiphon, Patnarin, Tipduangta, Pratchaya
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 18-08-2024
MDPI
Subjects:
3-D printers
3D printing
Controlled release
Copolymers
Design of experiments
Design optimization
Design specifications
DoE
Erectile dysfunction
Extrusion
Formulations
Levodopa
Mucuna
Mucuna extract
Optimization
Polymer blends
Polymers
Polyvinyl alcohol
Printing
Quality of life
Semisolids
Side effects
Slurries
Solidification
sustained release
Tablets
Three dimensional printing
Viscosity
DoE
Mucuna extract
optimization
sustained release
3D printing
erectile dysfunction
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Summary:Erectile dysfunction (ED) refers to the inability of the penis to maintain a firm erection during sexual activity. Mucuna, or , contains levodopa, a compound showing promise in ED treatment. However, formulating Mucuna extract into tablet dosage forms is challenging due to its semisolid nature. This study aimed to develop sustained-release tablets containing Mucuna extract via semisolid extrusion 3D printing. Eudragit RS PO (Eudragit) served as a sustained-release polymer, with poly (vinyl alcohol) (PVA) as a co-polymer for forming the tablet matrices. This study had the following two main phases: screening, which identified the factors affecting the printability, and optimization, which focused on the factors influencing the levodopa release and its consistency. The results showed that both the polymeric solid percentage content (PSPC) in the semisolid slurry and the Eudragit-PVA ratio significantly affected the printability. All of the formulations were printable, and the PSPC and Eudragit-PVA ratios were incorporated into the optimized model. The desired formulation, achieving targeted levodopa release and consistency, had a PSPC of 58.8% and a Eudragit-PVA ratio of 2.87:1. In conclusion, semisolid extrusion 3D printing guided by the design of experiments (DoE) proved feasible for producing reliable 3D-printed tablets with consistent active ingredients and desired release rates.
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ISSN:2223-7747
2223-7747
DOI:10.3390/plants13162294