Search Results - "Watt, T."

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation by Tripathi, Vidisha, Ellis, Jonathan D., Shen, Zhen, Song, David Y., Pan, Qun, Watt, Andrew T., Freier, Susan M., Bennett, C. Frank, Sharma, Alok, Bubulya, Paula A., Blencowe, Benjamin J., Prasanth, Supriya G., Prasanth, Kannanganattu V.

“…Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased transcriptome and proteomic complexity. The serine/arginine (SR)…”
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Systematic characterization of morphotectonic variability along the Cascadia convergent margin; implications for shallow megathrust behavior and tsunami hazards by Watt, Janet T, Brothers, Daniel S

“…Studies of recent destructive megathrust earthquakes and tsunamis along subduction margins in Japan, Sumatra, and Chile have linked forearc morphology and…”
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Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle by McNally, Ben D., Ashley, Dean F., Hänschke, Lea, Daou, Hélène N., Watt, Nicole T., Murfitt, Steven A., MacCannell, Amanda D. V., Whitehead, Anna, Bowen, T. Scott, Sanders, Francis W. B., Vacca, Michele, Witte, Klaus K., Davies, Graeme R., Bauer, Reinhard, Griffin, Julian L., Roberts, Lee D.

“…The endoplasmic reticulum (ER) regulates cellular protein and lipid biosynthesis. ER dysfunction leads to protein misfolding and the unfolded protein response…”
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Towards clinical application of freehand optical ultrasound imaging by Watt, Fraser T., Mackle, Eleanor C., Zhang, Edward Z., Beard, Paul C., Alles, Erwin J.

“…Freehand optical ultrasound (OpUS) imaging is an emerging ultrasound imaging paradigm that uses an array of fibre-optic, photoacoustic ultrasound sources and a…”
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Marine Paleoseismic Evidence for Seismic and Aseismic Slip Along the Hayward‐Rodgers Creek Fault System in Northern San Pablo Bay by Watt, J. T., McGann, M. L., Takesue, R. K., Lorenson, T. D.

“…Distinguishing between seismic and aseismic fault slip in the geologic record is difficult, yet fundamental to estimating the seismic potential of faults and…”
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In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides by Southwell, Amber L, Skotte, Niels H, Kordasiewicz, Holly B, Østergaard, Michael E, Watt, Andrew T, Carroll, Jeffrey B, Doty, Crystal N, Villanueva, Erika B, Petoukhov, Eugenia, Vaid, Kuljeet, Xie, Yuanyun, Freier, Susan M, Swayze, Eric E, Seth, Punit P, Bennett, Clarence Frank, Hayden, Michael R

“…Huntington disease (HD) is a dominant, genetic neurodegenerative disease characterized by progressive loss of voluntary motor control, psychiatric disturbance,…”
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Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients by Skotte, Niels H, Southwell, Amber L, Østergaard, Michael E, Carroll, Jeffrey B, Warby, Simon C, Doty, Crystal N, Petoukhov, Eugenia, Vaid, Kuljeet, Kordasiewicz, Holly, Watt, Andrew T, Freier, Susan M, Hung, Gene, Seth, Punit P, Bennett, C Frank, Swayze, Eric E, Hayden, Michael R

“…Huntington disease (HD) is an inherited, fatal neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. The mutant protein causes…”
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PTPRD and DCC Are Novel BACE1 Substrates Differentially Expressed in Alzheimer's Disease: A Data Mining and Bioinformatics Study by Taylor, Hannah A, Simmons, Katie J, Clavane, Eva M, Trevelyan, Christopher J, Brown, Jane M, Przemyłska, Lena, Watt, Nicole T, Matthews, Laura C, Meakin, Paul J

“…The β-site Amyloid precursor protein Cleaving Enzyme 1 (BACE1) is an extensively studied therapeutic target for Alzheimer's disease (AD), owing to its role in…”
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Cellular prion protein regulates β-secretase cleavage of the Alzheimer's amyloid precursor protein by Parkin, Edward T, Watt, Nicole T, Hussain, Ishrut, Eckman, Elizabeth A, Eckman, Christopher B, Manson, Jean C, Baybutt, Herbert N, Turner, Anthony J, Hooper, Nigel M

“…Proteolytic processing of the amyloid precursor protein (APP) by β-secretase, β-site APP cleaving enzyme (BACE1), is the initial step in the production of the…”
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The Role of Zinc in Alzheimer's Disease by Watt, Nicole T., Whitehouse, Isobel J., Hooper, Nigel M.

“…Zinc, the most abundant trace metal in the brain, has numerous functions, both in health and in disease. Zinc is released into the synaptic cleft of…”
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Increased Risk of Long-Term Sickness Absence, Lower Rate of Return to Work, and Higher Risk of Unemployment and Disability Pensioning for Thyroid Patients: A Danish Register-Based Cohort Study by Nexo, M. A, Watt, T, Pedersen, J, Bonnema, S. J, Hegedüs, L, Rasmussen, A. K, Feldt-Rasmussen, U, Bjorner, J. B

“…Context: Little is known about how thyroid diseases affect work ability. Objective: The objective of this study was to evaluate the risk of work disability for…”
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Control of RNA processing by a large non-coding RNA over-expressed in carcinomas by Lin, Rui, Roychowdhury-Saha, Manami, Black, Chris, Watt, Andrew T., Marcusson, Eric G., Freier, Susan M., Edgington, Thomas S.

“…RNA processing is vital for the high fidelity and diversity of eukaryotic transcriptomes and the encoded proteomes. However, control of RNA processing is not…”
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An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA by Seth, Punit P, Allerson, Charles R, Berdeja, Andres, Siwkowski, Andrew, Pallan, Pradeep S, Gaus, Hans, Prakash, Thazha P, Watt, Andrew T, Egli, Martin, Swayze, Eric E

“…We show for the first time that it is possible to obtain LNA-like (Locked Nucleic Acid 1) binding affinity and biological activity with carbocyclic LNA (cLNA)…”
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Dual Mechanisms for Shedding of the Cellular Prion Protein by Parkin, Edward T., Watt, Nicole T., Turner, Anthony J., Hooper, Nigel M.

“…The cellular prion protein (PrPC) is essential for the pathogenesis and transmission of prion diseases. Whereas the majority of PrPC is bound to the cell…”
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Mechanical Circulatory Support Use in the Context of Updated Heart Transplant Allocation Policy in the U.S. - Analysis of OPTN Data by Cascino, T., Stehlik, J., Cherikh, W., Cheng, Y., Watt, T.M., Brescia, A.A., Thompson, M.P., McCullough, J.S., Zhang, M., Shore, S., Pagani, F.D., Likosky, D.S., Aaronson, K.D.

“…The goals of the October 2018 U.S. heart allocation policy update were to improve geographical equity in access to heart transplant, decrease waitlist…”
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Generalizability of Left Ventricular Assist Device Clinical Trial Findings: An Analysis of the INTERMACS Database by Brescia, A.A., Watt, T.M., Pagani, F.D., Cascino, T.M., Zhang, M., McCullough, J.S., Shore, S., Likosky, D.S., Aaronson, K.D., Thompson, M.P.

“…Clinical trials assessing durable LVAD therapy have demonstrated survival benefits that have increased adoption. However, highly selected trial populations may…”
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Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration by Lagier-Tourenne, Clotilde, Baughn, Michael, Rigo, Frank, Sun, Shuying, Liu, Patrick, Li, Hai-Ri, Jiang, Jie, Watt, Andrew T, Chun, Seung, Katz, Melanie, Qiu, Jinsong, Sun, Ying, Ling, Shuo-Chien, Zhu, Qiang, Polymenidou, Magdalini, Drenner, Kevin, Artates, Jonathan W, McAlonis-Downes, Melissa, Markmiller, Sebastian, Hutt, Kasey R, Pizzo, Donald P, Cady, Janet, Harms, Matthew B, Baloh, Robert H, Vandenberg, Scott R, Yeo, Gene W, Fu, Xiang-Dong, Bennett, C Frank, Cleveland, Don W, Ravits, John

“…Expanded hexanucleotide repeats in the chromosome 9 open reading frame 72 (C9orf72) gene are the most common genetic cause of ALS and frontotemporal…”
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A consolidated analysis of the physiologic and molecular responses induced under acid stress in the legume-symbiont model-soil bacterium Sinorhizobium meliloti by Draghi, W. O., Del Papa, M. F., Hellweg, C., Watt, S. A., Watt, T. F., Barsch, A., Lozano, M. J., Lagares, A., Salas, M. E., López, J. L., Albicoro, F. J., Nilsson, J. F., Torres Tejerizo, G. A., Luna, M. F., Pistorio, M., Boiardi, J. L., Pühler, A., Weidner, S., Niehaus, K., Lagares, A.

“…Abiotic stresses in general and extracellular acidity in particular disturb and limit nitrogen-fixing symbioses between rhizobia and their host legumes. Except…”
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Posttraumatic Hypopituitarism Is Associated with an Unfavorable Body Composition and Lipid Profile, and Decreased Quality of Life 12 Months after Injury by Klose, M., Watt, T., Brennum, J., Feldt-Rasmussen, U.

“…Objective: Our objective was to describe body composition, lipid profile, and health-related quality of life (HRQL) in patients with traumatic brain injury…”
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Distinct, common and synergistic effects of insulin and IGF-1 receptors on healthy murine ageing by Walker, Andrew MN, Watt, Nicole T., Yuldasheva, Nadira Y., Dalmia, Sanjush, Conning-Rowland, Marcella, Cheng, Chew W., Warmke, Nele, Bridge, Katherine, Brown, Oliver I., Luk, Cheukyau, Drozd, Michael, Haywood, Natalie J., Skromna, Anna, Makava, Natasha, Wheatcroft, Stephen B., Kearney, Mark T., Cubbon, Richard M.

“…Reduced IGF-1 signalling is an evolutionarily conserved mediator of longevity, yet the magnitude of this effect is substantially larger in organisms retaining…”
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