Search Results - "Watt, Julie C"

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia by Konopleva, Marina, Contractor, Rooha, Tsao, Twee, Samudio, Ismael, Ruvolo, Peter P., Kitada, Shinichi, Deng, Xingming, Zhai, Dayong, Shi, Yue-Xi, Sneed, Thomas, Verhaegen, Monique, Soengas, Maria, Ruvolo, Vivian R., McQueen, Teresa, Schober, Wendy D., Watt, Julie C., Jiffar, Tilahun, Ling, Xiaoyang, Marini, Frank C., Harris, David, Dietrich, Martin, Estrov, Zeev, McCubrey, James, May, W. Stratford, Reed, John C., Andreeff, Michael

“…BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity…”
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Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells by Ruvolo, Peter P., Zhou, Liran, Watt, Julie C., Ruvolo, Vivian R., Burks, Jared K., Jiffar, Tilahun, Kornblau, Steven, Konopleva, Marina, Andreeff, Michael

“…Recent studies in acute myeloid leukemia (AML) suggest activation of pro‐proliferative signaling cascades including those mediated by protein kinase C (PKC)…”
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Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK by Nica, Alina Felicia, Tsao, Chun Chui, Watt, Julie C., Jiffar, Tilahun, Kurinna, Svitlana, Jurasz, Paul, Konopleva, Marina, Andreeff, Michael, Radomski, Marek W., Ruvolo, Peter P.

“…Ceramide is a sphingolipid that activates stress kinases such as p38 and c-JUN N-Terminal Kinase (JNK). Though Chronic Myelogenous Leukemia (CML) derived K562…”
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CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer–binding protein alpha by Koschmieder, Steffen, D'Alò, Francesco, Radomska, Hanna, Schöneich, Christine, Chang, Ji Suk, Konopleva, Marina, Kobayashi, Susumu, Levantini, Elena, Suh, Nanjoo, Di Ruscio, Annalisa, Voso, Maria Teresa, Watt, Julie C., Santhanam, Ramasamy, Sargin, Bülent, Kantarjian, Hagop, Andreeff, Michael, Sporn, Michael B., Perrotti, Danilo, Berdel, Wolfgang E., Müller-Tidow, Carsten, Serve, Hubert, Tenen, Daniel G.

“…2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces differentiation and apoptosis of tumor cells in vitro and in vivo. Here we assessed the effects of…”
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PPARgamma-Active triterpenoid CDDO enhances ATRA-induced differentiation in APL by Tabe, Yoko, Konopleva, Marina, Kondo, Yutaka, Contractor, Rooha, Tsao, Twee, Konoplev, Sergej, Shi, Yuexi, Ling, Xiaoyang, Watt, Julie C., Tsutsumi-Ishii, Yuko, Ohsaka, Akimichi, Nagaoka, Isao, Issa, Jean-Pierre, Kogan, Scott C., Andreeff, Michael

“…Acute promyelocytic leukemia (APL) is associated with oncogenic PML-RARα that acts as a dominant negative transcriptional repressor of retinoic acid (RA)…”
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Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia by Tsao, Twee, Kornblau, Steven, Safe, Stephen, Watt, Julie C, Ruvolo, Vivian, Chen, Wenjing, Qiu, Yihua, Coombes, Kevin R, Ju, Zhenlin, Abdelrahim, Maen, Schober, Wendy, Ling, Xiaoyang, Kardassis, Dimitris, Meyer, Colin, Schimmer, Aaron, Kantarjian, Hagop, Andreeff, Michael, Konopleva, Marina

“…Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a member of the nuclear receptor (NR) family of transcription factors with important regulatory…”
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Activation of p53 signaling by MI-63 induces apoptosis in acute myeloid leukemia cells by Samudio, Ismael J., Duvvuri, Seshagiri, Clise-Dwyer, Karen, Watt, Julie C., Mak, Duncan, Kantarjian, Hagop, Yang, Dajun, Ruvolo, Vivian, Borthakur, Gautam

“…Non-mutational inactivation of p53 is frequent in acute myeloid leukemia (AML) via overexpression of MDM2. We report that treatment with MI-63, a novel…”
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Cellular Transformation by the HTLV-I Tax Protein, a Jack-of-All-Trades by Gatza, Michael L, Watt, Julie C, Marriott, Susan J

“…The human T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that is responsible for adult T-cell leukemia and a neurological disease,…”
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Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis by MOORE, Lynette, VENKATACHALAM, Sundaresan, VOGEL, Hannes, WATT, Julie C, WU, Chao-Ling, STEINMAN, Heather, JONES, Stephen N, DONEHOWER, Lawrence A

“…The p19ARF gene product responds to oncogenic stresses by interfering with the inhibitory effects of Mdm2 on p53, thus enhancing p53 activity and its…”
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Targeting IL3 Receptor in Chronic Myeloid Leukemia by Frolova, Olga, Wang, Rui-Yu, Korchin, Borys, Watt, Julie C., Cortes, Jorge, Frankel, Arthur E., Kantarjian, Hagop M., Andreeff, Michael, Konopleva, Marina

“…Abstract 2172 Poster Board II-149 Despite the great success of imatinib therapy in chronic myeloid leukemia (CML), the presence of a residual leukemic clone is…”
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Role of peroxisome proliferator-activated receptor-γ and its co-activator DRIP205 in cellular responses to CDDO (RTA-401) in AML by Tsao, Twee, Kornblau, Steven, Safe, Stephen, Watt, Julie C., Ruvolo, Vivian, Chen, Wenjing, Qiu, Yihua, Coombes, Kevin R., Ju, Zhenlin, Abdelrahim, Maen, Schober, Wendy, Ling, Xiaoyang, Kardassis, Dimitris, Meyer, Colin, Schimmer, Aaron, Kantarjian, Hagop, Andreeff, Michael, Konopleva, Marina

“…Peroxisome proliferator-activated receptor-γ (PPARγ) is a member of the nuclear receptor family of transcription factors with important regulatory roles in…”
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Role of Peroxisome Proliferator-Activated Receptor-y and Its Coactivator DRIP205 in Cellular Responses to CDDO (RTA-401) in Acute Myelogenous Leukemia by TSAO, Twee, KORNBLAU, Steven, SCHOBER, Wendy, XIAOYANG LING, KARDASSIS, Dimitris, MEYER, Colin, SCHIMMER, Aaron, KANTARJIAN, Hagop, ANDREEFF, Michael, KONOPLEVA, Marina, SAFE, Stephen, WATT, Julie C, RUVOLO, Vivian, WENJING CHEN, YIHUA QIU, COOMBES, Kevin R, ZHENLIN JU, ABDELRAHIM, Maen

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Activation of p53 signaling by MI-63 induces apoptosis in acute myelogenous leukemia cells by Samudio, Ismael J, Duvvuri, Seshagiri, Clise-Dwyer, Karen, Watt, Julie C, Mak, Duncan, Kantarjian, Hagop, Yang, Dajun, Ruvolo, Vivian, Borthakur, Gautam

“…Non-mutational inactivation of p53 is frequent in acute myeloid leukemia (AML) via overexpression of MDM2. We report that treatment with MI-63, a novel…”
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Cooperativity of p19 , Mdm2, and p53 in murine tumorigenesis

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Inhibition of Bcl-2 Signaling by Small Molecule BH3 Inhhibitor GX15-070 as a Novel Therapeutic Strategy in AML by Watt, Julie C., Konopleva, Marina, Contractor, Rooha, Samudio, Ismael, Harris, David, Estrov, Zeev, Viallet, Jean, Andreeff, Michael

“…GX15-070 is a novel cycloprodigiosin derived small molecule BH3 inhibitor that binds with moderate affinity to all antiapoptotic Bcl-2 family members,…”
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A Novel Peptide Containing a Nine Amino Acid Sequence from Nur77 Induces Bcl-2-Dependent Apoptosis in AML by Andreeff, Michael, Konopleva, Marina, Watt, Julie C., Samudio, Ismael J., Satterthwait, Arnold C., Kitada, Shinichi, Zhang, Xiao-kun, Reed, John C.

“…Nur77 (also known as TR3 and NGFI-B) is a nuclear orphan receptor that in response to various stimuli can translocate from the nucleus to the mitochondria,…”
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Cellular transformation by the HTLV-I Tax protein, a Jack-of-All-Trades: Cancer Viruses by GATZA, Michael L, WATT, Julie C, MARRIOTT, Susan J

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