Search Results - "Watt, Danielle L."

RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA by Lazzaro, Federico, Novarina, Daniele, Amara, Flavio, Watt, Danielle L., Stone, Jana E., Costanzo, Vincenzo, Burgers, Peter M., Kunkel, Thomas A., Plevani, Paolo, Muzi-Falconi, Marco

“…The chemical identity and integrity of the genome is challenged by the incorporation of ribonucleoside triphosphates (rNTPs) in place of deoxyribonucleoside…”
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Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance by Rentoft, Matilda, Lindell, Kristoffer, Tran, Phong, Chabes, Anna Lena, Buckland, Robert J., Watt, Danielle L., Marjavaara, Lisette, Nilsson, Anna Karin, Melin, Beatrice, Trygg, Johan, Johansson, Erik, Chabes, Andrei

“…Even small variations in dNTP concentrations decrease DNA replication fidelity, and this observation prompted us to analyze genomic cancer data formutations in…”
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Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools by Watt, Danielle L, Buckland, Robert J, Lujan, Scott A, Kunkel, Thomas A, Chabes, Andrei

“…The absolute and relative concentrations of the four dNTPs are key determinants of DNA replication fidelity, yet the consequences of altered dNTP pools on…”
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Altered dNTP pools accelerate tumor formation in mice by Tran, Phong, Mishra, Pradeep, Williams, Leonard G, Moskalenko, Roman, Sharma, Sushma, Nilsson, Anna Karin, Watt, Danielle L, Andersson, Pernilla, Bergh, Anders, Pursell, Zachary F, Chabes, Andrei

“…Alterations in deoxyribonucleoside triphosphate (dNTP) pools have been linked to increased mutation rates and genome instability in unicellular organisms and…”
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Increased and imbalanced dNTP pools symmetrically promote both leading and lagging strand replication infidelity by Buckland, Robert J, Watt, Danielle L, Chittoor, Balasubramanyam, Nilsson, Anna Karin, Kunkel, Thomas A, Chabes, Andrei

“…The fidelity of DNA replication requires an appropriate balance of dNTPs, yet the nascent leading and lagging strands of the nuclear genome are primarily…”
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Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases by Nick McElhinny, Stephanie A, Watts, Brian E, Kumar, Dinesh, Watt, Danielle L, Lundström, Else-Britt, Burgers, Peter M.J, Johansson, Erik, Chabes, Andrei, Kunkel, Thomas A

“…Measurements of nucleoside triphosphate levels in Saccharomyces cerevisiae reveal that the four rNTPs are in 36- to 190-fold molar excess over their…”
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Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases by Watt, Danielle L., Johansson, Erik, Burgers, Peter M., Kunkel, Thomas A.

“…► rNMPs embedded in DNA impede synthesis by B-Family polymerases. ► rNMP bypass efficiencies are comparable to those for 8-oxo-guanine. ► HU sensitivity of…”
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Genome instability due to ribonucleotide incorporation into DNA by Kunkel, Thomas A, McElhinny, Stephanie A Nick, Kumar, Dinesh, Clark, Alan B, Watt, Danielle L, Watts, Brian E, Lundström, Else-Britt, Johansson, Erik, Chabes, Andrei

“…Polymerase exclusion of ribonucleotides during DNA replication is imperfect. New data indicate that DNA polymerase ϵ incorporates into DNA ribonucleotides that…”
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Elimination of rNMPs from mitochondrial DNA has no effect on its stability by Wanrooij, Paulina H., Tran, Phong, Thompson, Liam J., Carvalho, Gustavo, Sharma, Sushma, Kreisel, Katrin, Navarrete, Clara, Feldberg, Anna-Lena, Watt, Danielle L., Nilsson, Anna Karin, Engqvist, Martin K. M., Clausen, Anders R., Chabes, Andrei

“…Ribonucleotides (rNMPs) incorporated in the nuclear genome are a well-established threat to genome stability and can result in DNA strand breaks when not…”
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Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity by Daly, Janssen, Bebenek, Katarzyna, Watt, Danielle L, Richter, Kathleen, Jiang, Chuancang, Zhao, Ming-Lang, Ray, Madhumita, McGregor, W Glenn, Kunkel, Thomas A, Diaz, Marilyn

“…To test the hypothesis that DNA polymerase ζ participates in Ig hypermutation, we generated two mouse models of Pol ζ function: a B cell-specific conditional…”
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Mutagenicity of the 1-Nitropyrene-DNA Adduct N-(Deoxyguanosin-8-yl)-1-aminopyrene in Mammalian Cells by Watt, Danielle L, Utzat, Christopher D, Hilario, Pablo, Basu, Ashis K

“…The mutagenesis of the major DNA adduct N-(deoxyguanosin-8-yl)-1-aminopyrene (C8-AP-dG) formed by 1-nitropyrene was compared with the analogous C8-dG adducts…”
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Polycyclic aromatic hydrocarbon-DNA adducts determined by semiquantitative immunohistochemistry in human esophageal biopsies taken in 1985 by van Gijssel, Hilde E, Schild, Laura J, Watt, Danielle L, Roth, Mark J, Wang, Guo-Qing, Dawsey, Sanford M, Albert, Paul S, Qiao, You-Lin, Taylor, Philip R, Dong, Zhi-Wei, Poirier, Miriam C

“…Esophageal endoscopic biopsy samples were obtained in 1985 in Linxian, China, a region with very high esophageal cancer incidence rates, and where ingested…”
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Increased and Imbalanced dNTP Pools Symmetrically Promote Both Leading and Lagging Strand Replication Infidelity: e1004846 by Buckland, Robert J, Watt, Danielle L, Chittoor, Balasubramanyam, Nilsson, Anna Karin, Kunkel, Thomas A, Chabes, Andrei

“…The fidelity of DNA replication requires an appropriate balance of dNTPs, yet the nascent leading and lagging strands of the nuclear genome are primarily…”
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Altered immunoglobulin hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity by Daly, Janssen, Bebenek, Katarzyna, Watt, Danielle L., Richter, Kathleen, Jiang, Chuancang, Zhao, Ming-Lang, Ray, Madhumita, McGregor, W. Glenn, Kunkel, Thomas A., Diaz, Marilyn

“…To test the hypothesis that DNA polymerase ζ participates in immunoglobulin hypermutation, we generated two mouse models of Pol ζ function: a B-cell specific…”
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Mutagenicity of N-(deoxyguanosin-8-yl)-1-aminopyrene, the major DNA adduct formed by 1-nitropyrene, in mammalian cells by Watt, Danielle L

“…N-(deoxyguanosin-8-yl)-1-aminopyrene (AP-dG) is the major DNA adduct formed in a cell following metabolism of 1-nitropyrene, a carcinogenic nitro-aromatic…”
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