Search Results - "Watson, Zoe L."

Structure of the bacterial ribosome at 2 Å resolution by Watson, Zoe L, Ward, Fred R, Méheust, Raphaël, Ad, Omer, Schepartz, Alanna, Banfield, Jillian F, Cate, Jamie Hd

“…Using cryo-electron microscopy (cryo-EM), we determined the structure of the 70S ribosome with a global resolution of 2.0 Å. The maps reveal unambiguous…”
Get full text

Rare ribosomal RNA sequences from archaea stabilize the bacterial ribosome by Nissley, Amos J, Penev, Petar I, Watson, Zoe L, Banfield, Jillian F, Cate, Jamie H D

“…The ribosome serves as the universally conserved translator of the genetic code into proteins and supports life across diverse temperatures ranging from below…”
Get full text

Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition by Travin, Dmitrii Y., Watson, Zoe L., Metelev, Mikhail, Ward, Fred R., Osterman, Ilya A., Khven, Irina M., Khabibullina, Nelli F., Serebryakova, Marina, Mergaert, Peter, Polikanov, Yury S., Cate, Jamie H. D., Severinov, Konstantin

“…Ribosome-synthesized post-translationally modified peptides (RiPPs) represent a rapidly expanding class of natural products with various biological activities…”
Get full text

mRNA decoding in human is kinetically and structurally distinct from bacteria by Holm, Mikael, Natchiar, S. Kundhavai, Rundlet, Emily J., Myasnikov, Alexander G., Watson, Zoe L., Altman, Roger B., Wang, Hao-Yuan, Taunton, Jack, Blanchard, Scott C.

“…In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA) nucleotide sequences using aminoacyl-tRNA substrates. Current…”
Get full text

Anionic G•U pairs in bacterial ribosomal rRNAs by Westhof, Eric, Watson, Zoe L, Zirbel, Craig L, Cate, Jamie H D

“…Wobble GU pairs (or G•U) occur frequently within double-stranded RNA helices interspersed between standard G=C and A-U Watson-Crick pairs. Another type of G•U…”
Get full text

Atomistic simulations of the Escherichia coli ribosome provide selection criteria for translationally active substrates by Watson, Zoe L., Knudson, Isaac J., Ward, Fred R., Miller, Scott J., Cate, Jamie H. D., Schepartz, Alanna, Abramyan, Ara M.

“…As genetic code expansion advances beyond l -α-amino acids to backbone modifications and new polymerization chemistries, delineating what substrates the…”
Get full text

Defects in the Assembly of Ribosomes Selected for β‑Amino Acid Incorporation by Ward, Fred R, Watson, Zoe L, Ad, Omer, Schepartz, Alanna, Cate, Jamie H. D

“…Ribosome engineering has emerged as a promising field in synthetic biology, particularly concerning the production of new sequence-defined polymers. Mutant…”
Get full text