Search Results - "Watson, Susan R."

Gene Expression Profiles Distinguish Idiopathic Pulmonary Fibrosis from Hypersensitivity Pneumonitis by Selman, Moises, Pardo, Annie, Barrera, Lourdes, Estrada, Andrea, Watson, Susan R, Wilson, Keith, Aziz, Natasha, Kaminski, Naftali, Zlotnik, Albert

“…Many of the interstitial lung diseases represent a diagnostic and therapeutic challenge because their clinical and even histologic features are often…”
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Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment by Han, Brenda Y, Wu, Shuang, Foo, Chuan-Sheng, Horton, Robert M, Jenne, Craig N, Watson, Susan R, Whittle, Belinda, Goodnow, Chris C, Cyster, Jason G

“…The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have…”
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Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity by Corbin, John A, Bhaskar, Vinay, Goldfine, Ira D, Bedinger, Daniel H, Lau, Angela, Michelson, Kristen, Gross, Lisa M, Maddux, Betty A, Kuan, Hua F, Tran, Catarina, Lao, Llewelyn, Handa, Masahisa, Watson, Susan R, Narasimha, Ajay J, Zhu, Shirley, Levy, Raphael, Webster, Lynn, Wijesuriya, Sujeewa D, Liu, Naichi, Wu, Xiaorong, Chemla-Vogel, David, Lee, Steve R, Wong, Steve, Wilcock, Diane, White, Mark L

“…Previously we reported studies of XMetA, an agonist antibody to the insulin receptor (INSR). We have now utilized phage display to identify XMetS, a novel…”
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An integrative biology approach for analysis of drug action in models of human vascular inflammation by Kunkel, Eric J., Dea, Marlene, Ebens, Allen, Hytopoulos, Evangelos, Melrose, Jennifer, Nguyen, Dat, Ota, Ken S., Plavec, Ivan, Wang, Yuker, Watson, Susan R., Butcher, Eugene C., Berg, Ellen L.

“…ABSTRACT Unexpected drug activities discovered during clinical testing establish the need for better characterization of compounds in human disease‐relevant…”
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T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow by Jenne, Craig N, Enders, Anselm, Rivera, Richard, Watson, Susan R, Bankovich, Alexander J, Pereira, Joao P, Xu, Ying, Roots, Carla M, Beilke, Joshua N, Banerjee, Arnob, Reiner, Steven L, Miller, Sara A, Weinmann, Amy S, Goodnow, Chris C, Lanier, Lewis L, Cyster, Jason G, Chun, Jerold

“…During a screen for ethylnitrosourea-induced mutations in mice affecting blood natural killer (NK) cells, we identified a strain, designated Duane, in which NK…”
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The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency by Roadcap, David W, Jenne, Craig N, Watson, Susan R, Cyster, Jason G, Paris, Kenneth, Sorensen, Ricardo U, Goodnow, Christopher C, Shiow, Lawrence R, Bear, James E, Föger, Niko, Grigorova, Irina L, An, Jinping, Lebet, Tonya, Xu, Ying, Puck, Jennifer M

“…Defective thymic egress in mice is associated with the peripheral T cell deficiency ( Ptcd ) locus. Cyster and colleagues find that the actin regulator coronin…”
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DAP12: an adapter protein with dual functionality by Takaki, Rayna, Watson, Susan R., Lanier, Lewis L.

“…Expressed predominantly on myeloid and natural killer (NK) cells, DAP12 is an adapter protein that can associate with a variety of receptors. To date, DAP12…”
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A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control by BHASKAR, Vinay, GOLDFINE, Ira D, NARASIMHA, Ajay J, LEVY, Raphael, WEBSTER, Lynn, WIJESURIYA, Sujeewa D, NAICHI LIU, XIAORONG WU, CHEMLA-VOGEL, David, TRAN, Catarina, LEE, Steve R, WONG, Steve, BEDINGER, Daniel H, WILCOCK, Diane, WHITE, Mark L, CORBIN, John A, LAU, Angela, KUAN, Hua F, GROSS, Lisa M, HANDA, Masahisa, MADDUX, Betty A, WATSON, Susan R, ZHU, Shirley

“…Many patients with diabetes mellitus (both type 1 and type 2) require therapy to maintain normal fasting glucose levels. To develop a novel treatment for these…”
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Discovery of diverse and functional antibodies from large human repertoire antibody libraries by Schwimmer, Lauren J., Huang, Betty, Giang, Hoa, Cotter, Robyn L., Chemla-Vogel, David S., Dy, Francis V., Tam, Eric M., Zhang, Fangjiu, Toy, Pamela, Bohmann, David J., Watson, Susan R., Beaber, John W., Reddy, Nithin, Kuan, Hua-Feng, Bedinger, Daniel H., Rondon, Isaac J.

“…Phage display antibody libraries have a proven track record for the discovery of therapeutic human antibodies, increasing the demand for large and diverse…”
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Th17 Augmentation in OTII TCR Plus T Cell-Selective Type 1 Sphingosine 1-Phosphate Receptor Double Transgenic Mice by Huang, Mei-Chuan, Watson, Susan R, Liao, Jia-Jun, Goetzl, Edward J

“…Sphingosine 1-phosphate (S1P) in blood and lymph controls lymphoid traffic and tissue migration of T cells through signals from the type 1 S1PR (S1P(1)), but…”
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Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases by Hesslein, David G.T., Palacios, Emil H., Sun, Joseph C., Beilke, Joshua N., Watson, Susan R., Weiss, Arthur, Lanier, Lewis L.

“…The protein tyrosine phosphatase CD45 is an important regulator of Src-family kinase activity. We found that in the absence of CD45, natural killer (NK) cells…”
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Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: A potential new approach for the treatment of hyperinsulinemic hypoglycemia by Corbin, John A, Bhaskar, Vinay, Goldfine, Ira D, Issafras, Hassan, Bedinger, Daniel H, Lau, Angela, Michelson, Kristen, Gross, Lisa M, Maddux, Betty A, Kuan, Hua F, Tran, Catarina, Lao, Llewelyn, Handa, Masahisa, Watson, Susan R, Narasimha, Ajay J, Zhu, Shirley, Levy, Raphael, Webster, Lynn, Wijesuriya, Sujeewa D, Liu, Naichi, Wu, Xiaorong, Chemla-Vogel, David, Lee, Steve R, Wong, Steve, Wilcock, Diane, Rubin, Paul, White, Mark L

“…Novel therapies are needed for the treatment of hypoglycemia resulting from both endogenous and exogenous hyperinsulinema. To provide a potential new treatment…”
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Site-specific Fucosylation of Sialylated Polylactosamines by alpha 1,3/4-Fucosyltransferases-V and -VI Is Defined by Amino Acids Near the N Terminus of the Catalytic Domain by Shetterly, Susan, Jost, Franziska, Watson, Susan R, Knegtel, Ronald, Macher, Bruce A, Holmes, Eric H

“…Fucose transfer from GDP-fucose to GlcNAc residues of the sialylated polylactosamine acceptor NeuAc alpha 2-3Gal beta 1-4Glc-NAc beta 1-3Gal beta 1-4GlcNAc…”
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The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis(x) oligosaccharide by Foxall, C, Watson, S R, Dowbenko, D, Fennie, C, Lasky, L A, Kiso, M, Hasegawa, A, Asa, D, Brandley, B K

“…The selectins (lectin-EGF-complement binding-cell adhesion molecules [LEC-CAMs]) are a family of mammalian receptors implicated in the initial interactions…”
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An endothelial ligand for L-selectin is a novel mucin-like molecule by Lasky, L A, Singer, M S, Dowbenko, D, Imai, Y, Henzel, W J, Grimley, C, Fennie, C, Gillett, N, Watson, S R, Rosen, S D

“…The adhesive interaction between circulating lymphocytes and the high endothelial venules (HEV) of lymph nodes (LN) is mediated by lymphocyte L-selectin, a…”
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Neutrophil influx into an inflammatory site inhibited by a soluble homing receptor-IgG chimaera by Watson, Susan R, Fennie, Christopher, Lasky, Laurence A

“…Neutrophil-mediated inflammation is involved in a number of human clinical manifestations, including the adult respiratory distress syndrome, multi-organ…”
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Lymphocyte migration into tissue: the paradigm derived from CD4 subsets by Bradley, Linda M, Watson, Susan R

“…The appropriate recirculation and migration of naive, effector and memory T cells into inflamed tissue are precisely controlled by adhesive interactions with…”
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The immune system and gene expression microarrays - new answers to old questions by J Glynne, Richard, R Watson, Susan

“…The recent increase in availability of gene expression technologies has the potential to dramatically expand our understanding of cellular immunology in…”
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Caspase-dependent proteolytic cleavage of STAT3α in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines by Matthews, James R, Watson, Susan MR, Tevendale, Maxine CL, Watson, Christine J, Clarke, Alan R

“…Abstract Background The STAT (Signal Transducers and Activators of Transcription) transcription factor family mediates cellular responses to a wide range of…”
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P- and E-Selectin Use Common Sites for Carbohydrate Ligand Recognition and Cell Adhesion by Erbe, David V., Watson, Susan R., Presta, Leonard G., Wolitzky, Barry A., Foxall, Carroll, Brandley, Brian K., Lasky, Laurence A.

“…The selectins are a family of three calcium-dependent lectins that mediate adhesive interactions between leukocytes and the endothelium during normal and…”
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