Search Results - "Watson, S P"

Genotyping and phenotyping of platelet function disorders by Watson, S. P., Lowe, G. C., Lordkipanidzé, M., Morgan, N. V.

“…Summary The majority of patients with platelet function disorders (PFDs) have normal platelet counts and mild day‐to‐day bleeding symptoms, but are at risk of…”
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Platelets and the innate immune system: mechanisms of bacterial‐induced platelet activation by COX, D., KERRIGAN, S. W., WATSON, S. P.

“…It has become clear that platelets are not simply cell fragments that plug the leak in a damaged blood vessel; they are, in fact, also key components in the…”
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Penetration of Fluoride into Natural Plaque Biofilms by Watson, P.S., Pontefract, H.A., Devine, D.A., Shore, R.C., Nattress, B.R., Kirkham, J., Robinson, C.

“…Caries occurs at inaccessible stagnation sites where plaque removal is difficult. Here, the penetration through plaque of protective components, such as…”
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A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen by Quek, L.S., Bolen, J., Watson, S.P.

“…Bruton's tyrosine kinase (Btk) is essential for normal B-cell receptor signalling. The lack of expression of functional Btk in humans leads to the B-cell…”
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Recommendations for the standardization of light transmission aggregometry: a consensus of the working party from the platelet physiology subcommittee of SSC/ISTH by Cattaneo, M., Cerletti, C., Harrison, P., Hayward, C. P. M., Kenny, D., Nugent, D., Nurden, P., Rao, A. K., Schmaier, A. H., Watson, S. P., Lussana, F., Pugliano, M. T., Michelson, A. D.

“…Light transmission aggregometry (LTA) is the most common method used to assess platelet function. However, there is no universal standard for its performance…”
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Utility of the ISTH bleeding assessment tool in predicting platelet defects in participants with suspected inherited platelet function disorders by Lowe, G. C., Lordkipanidzé, M., Watson, S. P.

“…Summary Background The ISTH bleeding assessment tool (ISTH‐BAT) was developed to record bleeding symptoms and to aid diagnosis in patients with a possible…”
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Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets by Poulter, N. S., Pollitt, A. Y., Owen, D. M., Gardiner, E. E., Andrews, R. K., Shimizu, H., Ishikawa, D., Bihan, D., Farndale, R. W., Moroi, M., Watson, S. P., Jung, S. M.

“…Essentials Dimeric high‐affinity collagen receptor glycoprotein VI (GPVI) is present on resting platelets. Spatio‐temporal organization of platelet GPVI‐dimers…”
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Akt and mitogen‐activated protein kinase enhance C‐type lectin‐like receptor 2‐mediated platelet activation by inhibition of glycogen synthase kinase 3α/β by Moroi, A. J., Watson, S. P.

“…Summary Background The C‐type lectin‐like receptor 2 (CLEC‐2) and the collagen receptor glycoprotein (GP)VI activate platelets through Src and Syk tyrosine…”
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GPVI and CLEC‐2 in hemostasis and vascular integrity by WATSON, S. P., HERBERT, J. M. J., POLLITT, A. Y.

“…The glycoprotein VI (GPVI)–FcR γ‐chain complex initiates powerful activation of platelets by the subendothelial matrix proteins collagen and laminin through an…”
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Comparison of multiple electrode aggregometry with lumi‐aggregometry for the diagnosis of patients with mild bleeding disorders by Al Ghaithi, R., Drake, S., Watson, S. P., Morgan, N. V., Harrison, P.

“…Essentials There is a clinical need for new technologies to measure platelet function in whole blood. Mild bleeding disorders were evaluated using multiple…”
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The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen by Poole, A., Gibbins, J.M., Turner, M., van Vugt, M.J., van de Winkel, J.G.J., Saito, T., Tybulewicz, V.L.J., Watson, S.P.

“…Activation of mouse platelets by collagen is associated with tyrosine phosphorylation of multiple proteins including the Fc receptor γ‐chain, the tyrosine…”
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Evaluation of the role of platelet integrins in fibronectin‐dependent spreading and adhesion by Mccarty, O. J. T., Zhao, Y., Andrew, N., Machesky, L. M., Staunton, D., Frampton, J., Watson, S. P.

“…Background: Recent studies have shown that platelet adhesion and subsequent aggregation can occur in vivo in the absence of the two principal platelets…”
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Mapping the platelet proteome: a report of the ISTH Platelet Physiology Subcommittee by WATSON, S. P., BAHOU, W. F., FITZGERALD, D., OUWEHAND, W., RAO, A. K., LEAVITT, A. D.

“…Proteomic technology has the potential to transform the way we analyze platelet biology, through the determination of platelet protein composition and its…”
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Use of next‐generation sequencing and candidate gene analysis to identify underlying defects in patients with inherited platelet function disorders by Leo, V. C., Morgan, N. V., Bem, D., Jones, M. L., Lowe, G. C., Lordkipanidzé, M., Drake, S., Simpson, M. A., Gissen, P., Mumford, A., Watson, S. P., Daly, M. E.

“…Summary Background Inherited platelet function disorders (PFDs) are heterogeneous, and identification of the underlying genetic defects is difficult when based…”
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The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen by Watson, S P, Asazuma, N, Atkinson, B, Berlanga, O, Best, D, Bobe, R, Jarvis, G, Marshall, S, Snell, D, Stafford, M, Tulasne, D, Wilde, J, Wonerow, P, Frampton, J

“…The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of…”
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Lack of effect of Coenzyme Q on left ventricular function in patients with congestive Heart failure by WATSON, P. S, SCALIA, G. M, GALBRAITH, A, BURSTOW, D. J, BETT, N, ARONEY, C. N

“…This study evaluated the effects of oral therapy with coenzyme Q on echocardiographic and hemodynamic indexes of left ventricular function and on quality of…”
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Evaluation of a whole blood remote platelet function test for the diagnosis of mild bleeding disorders by Dovlatova, N., Lordkipanidzé, M., Lowe, G. C., Dawood, B., May, J., Heptinstall, S., Watson, S. P., Fox, S. C.

“…Summary Background Mild platelet function disorders (PFDs) are complex and difficult to diagnose. The current gold standard test, light transmission…”
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Polymerisation of methyl methacrylate in a pilot-scale tubular reactor: modelling and experimental studies by Fan, S., Gretton-Watson, S.P., Steinke, J.H.G., Alpay, E.

“…A pilot-scale tubular reactor fitted with in-line static mixers is experimentally and theoretically evaluated for the polymerisation of methyl methacrylate…”
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Platelets and the innate immune system: mechanisms of bacterial‐induced platelet activation by COX, D., KERRIGAN, S.W., WATSON, S.P.

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Podoplanin‐expressing inflammatory macrophages activate murine platelets via CLEC‐2 by KERRIGAN, A. M., NAVARRO‐NUÑEZ, L., PYZ, E., FINNEY, B. A., WILLMENT, J. A., WATSON, S. P., BROWN, G. D.

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