Search Results - "Watson, R B"

Polarisation-sensitive optical coherence tomography measurement of retardance in fibrosis, a non-invasive biomarker in patients with systemic sclerosis by Marjanovic, E. J., Sharma, V., Smith, L., Pinder, C., Moore, T. L., Manning, J. B., Dinsdale, G., Berks, M., Newton, V. L., Wilkinson, S., Dickinson, M. R., Herrick, A. L., Watson, R. E. B., Murray, A. K.

“…Polarisation-sensitive optical coherence tomography (PS-OCT) offers a novel, non-invasive method of assessing skin fibrosis in the multisystem disease systemic…”
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Geographical ancestry is a key determinant of epidermal morphology and dermal composition by Langton, A.K., Sherratt, M.J., Sellers, W.I., Griffiths, C.E.M., Watson, R.E.B.

“…Summary Background Geographical ancestry plays a key role in determining the susceptibility of human skin to external insults and dermatological disease…”
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Altered cognitive function in men treated for prostate cancer with luteinizing hormone‐releasing hormone analogues and cyproterone acetate: a randomized controlled trial by Green, H.J., Pakenham, K.I., Headley, B.C., Yaxley, J., Nicol, D.L., Mactaggart, P.N., Swanson, C., Watson, R.B., Gardiner, R.A.

“…Objective  To report the first systematic investigation of the cognitive effects of luteinizing hormone‐releasing hormone (LHRH) analogues in male patients, as…”
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Quality of life compared during pharmacological treatments and clinical monitoring for non‐localized prostate cancer: a randomized controlled trial by Green, H.J., Pakenham, K.I., Headley, B.C., Yaxley, J., Nicol, D.L., Mactaggart, P.N., Swanson, C.E., Watson, R.B., Gardiner, R.A.

“…OBJECTIVES To investigate the effects of different management strategies for non‐localized prostate cancer on men's quality of life and cognitive functioning…”
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Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial by Rizwan, M., Rodriguez-Blanco, I., Harbottle, A., Birch-Machin, M.A., Watson, R.E.B., Rhodes, L.E.

“…Summary Background  Previous epidemiological, animal and human data report that lycopene has a protective effect against ultraviolet radiation (UVR)‐induced…”
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Novel approaches to characterize age-related remodelling of the dermal-epidermal junction in 2D, 3D and in vivo by Newton, V L, Bradley, R S, Seroul, P, Cherel, M, Griffiths, C E M, Rawlings, A V, Voegeli, R, Watson, R E B, Sherratt, M J

“…The dermal-epidermal junction (DEJ) forms epidermal protrusions down into the dermis (rete ridges) and dermal projections up into the epidermis (dermal…”
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The use of isotope-coded affinity tags (ICAT) to study organelle proteomes in Arabidopsis thaliana by Dunkley, T P J, Dupree, P, Watson, R B, Lilley, K S

“…Organelle proteomics is the analysis of the protein contents of a subcellular compartment. Proteins identified in subcellular proteomic studies can only be…”
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Positive surgical margins with radical prostatectomy: detailed pathological analysis and prognosis by Watson, Roger B., Civantos, Francisco, Soloway, Mark S.

“…Objectives. To examine the extent and location of positive surgical margins and their influence on progression. Methods. Two hundred fifteen consecutive…”
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Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma by Evangelou, G., Farrar, M.D., Cotterell, L., Andrew, S., Tosca, A.D., Watson, R.E.B., Rhodes, L.E.

“…Summary Background  Topical photodynamic therapy (PDT) is a widely applied treatment for basal cell carcinoma (BCC). PDT‐induced immunosuppression leading to…”
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Altered claudin expression is a feature of chronic plaque psoriasis by Watson, REB, Poddar, R, Walker, JM, McGuill, I, Hoare, LM, Griffiths, CEM, O'Neill, CA

“…Epithelial tight junctions play a central role in cell–cell adhesion and are necessary for the selective paracellular movement of ions. Claudins are key…”
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Topical aminolaevulinic acid-photodynamic therapy produces an inflammatory infiltrate but reduces Langerhans cells in healthy human skin in vivo by Evangelou, G., Farrar, M.D., White, R.D., Sorefan, N.B., Wright, K.P., McLean, K., Andrew, S., Watson, R.E.B., Rhodes, L.E.

“…Summary Background  Topical photodynamic therapy (PDT) elicits a therapeutic response in both skin cancer and immune‐mediated skin disorders. While PDT induces…”
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Repair of photoaged dermal matrix by topical application of a cosmetic 'antiageing' product by Watson, R.E.B., Long, S.P., Bowden, J.J., Bastrilles, J.Y., Barton, S.P., Griffiths, C.E.M.

“…Summary Background  Photoaged skin is characterized by coarse and fine wrinkles. The mechanism of wrinkle formation appears to involve changes to components of…”
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Identification of novel skin ageing genes: evidence from across the pigmentary continuum by Langton, A. K., Watson, R. E. B.

“…Linked Article: Chen et al. Br J Dermatol 2021; 185:988–998…”
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Should we look beyond the interferon signature in chilblain‐like lesions associated with COVID‐19? by Pilkington, S.M., Watson, R.E.B.

“…Linked Article: Frumholtz et al. Br J Dermatol 2021;185:1176–1185…”
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Aged human skin accumulates mast cells with altered functionality that localize to macrophages and vasoactive intestinal peptide‐positive nerve fibres by Pilkington, S.M., Barron, M.J., Watson, R.E.B., Griffiths, C.E.M., Bulfone‐Paus, S.

“…Summary Background Skin health declines with age and this is partially attributed to immunosenescence. Mast cells (MCs) are innate immune cells that coordinate…”
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The impact of perceived stress on skin ageing by Lee, C.M., Watson, R.E.B., Kleyn, C.E.

“…Skin ageing can be divided according to phenotypical features into intrinsic (by the passage of time) and extrinsic (with the addition of the effects of…”
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Retinoids in the treatment of photoageing: A histological study of topical retinoid efficacy in black skin by Halai, P., Kiss, O., Wang, R., Chien, A. L., Kang, S., O'Connor, C., Bell, M., Griffiths, C. E. M., Watson, R. E. B., Langton, A. K.

“…Background Photoageing describes complex cutaneous changes that occur due to chronic exposure to solar ultraviolet radiation (UVR). The ‘gold standard’ for the…”
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Organization of the dermal matrix impacts the biomechanical properties of skin by Langton, A.K., Graham, H.K., McConnell, J.C., Sherratt, M.J., Griffiths, C.E.M., Watson, R.E.B.

“…Summary Background Human skin has the crucial roles of maintaining homeostasis and protecting against the external environment. Skin offers protection against…”
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Distinctive clinical and histological characteristics of atrophic and hypertrophic facial photoageing by Langton, A.K., Ayer, J., Griffiths, T.W., Rashdan, E., Naidoo, K., Caley, M.P., Birch‐Machin, M.A., O'Toole, E.A., Watson, R.E.B., Griffiths, C.E.M.

“…Background Photoageing describes complex cutaneous changes which occur following chronic exposure to solar ultraviolet radiation (UVR). Amongst White Northern…”
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Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes by El‐Chami, C., Foster, A.R., Johnson, C., Clausen, R.P., Cornwell, P., Haslam, I.S., Steward, M.C., Watson, R.E.B., Young, H.S., O'Neill, C.A.

“…Summary Background The epidermal barrier is important for water conservation, failure of which is evident in dry‐skin conditions. Barrier function is fulfilled…”
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