Search Results - "Watson, Patricia M."

Understanding the Role of ETS-Mediated Gene Regulation in Complex Biological Processes by Findlay, Victoria J., LaRue, Amanda C., Turner, David P., Watson, Patricia M., Watson, Dennis K.

“…Ets factors are members of one of the largest families of evolutionarily conserved transcription factors, regulating critical functions in normal cell…”
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FLI1 Expression is Correlated with Breast Cancer Cellular Growth, Migration, and Invasion and Altered Gene Expression by Scheiber, Melissa N, Watson, Patricia M, Rumboldt, Tihana, Stanley, Connor, Wilson, Robert C, Findlay, Victoria J, Anderson, Paul E, Watson, Dennis K

“…Abstract ETS factors have been shown to be dysregulated in breast cancer. ETS factors control the expression of genes involved in many biological processes,…”
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Hematopoietic Stem Cell–Derived Cancer–Associated Fibroblasts Are Novel Contributors to the Pro-Tumorigenic Microenvironment by McDonald, Lindsay T, Russell, Dayvia L, Kelly, Ryan R, Xiong, Ying, Motamarry, Anjan, Patel, Risha K, Jones, Jeffrey A, Watson, Patricia M, Turner, David P, Watson, Dennis K, Soloff, Adam C, Findlay, Victoria J, LaRue, Amanda C

“…Abstract Targeting the tumor microenvironment is critical toward improving the effectiveness of cancer therapeutics. Cancer-associated fibroblasts (CAFs) are…”
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Mechanisms and functional consequences of PDEF protein expression loss during prostate cancer progression by Turner, David P., Findlay, Victoria J., Moussa, Omar, Semenchenko, Victor I., Watson, Patricia M., LaRue, Amanda C., Desouki, Mohamed M., Fraig, Mostafa, Watson, Dennis K.

“…BACKGROUND Ets is a large family of transcriptional regulators with functions in most biological processes. While the Ets family gene, prostate‐derived…”
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Novel Immunocompetent Murine Models Representing Advanced Local and Metastatic Pancreatic Cancer by Little, Elizabeth C., B.S, Wang, Cindy, Ph.D, Watson, Patricia M., Ph.D, Watson, Dennis K., Ph.D, Cole, David J., M.D, Camp, E. Ramsay, M.D

“…Background The development of novel therapeutics for pancreatic cancer has been hindered by a lack of relevant preclinical models. The purpose of this study…”
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Detection of human telomerase reverse transcriptase mRNA in cells obtained by lavage of the pleura is not associated with worse outcome in patients with stage I/II non–small cell lung cancer: Results from Cancer and Leukemia Group B 159902 by Boylan, Alice M., MD, Wang, Xiaofei F., PhD, Ko, Richard, DO, Watson, Patricia M., PhD, Gu, Lin, MS, Harpole, David, MD, Bueno, Raphael, MD, Kelly, Rosemary, MD, Kohman, Leslie, MD, Kratzke, Robert, MD

“…Objective Previous studies suggest that cytologic analysis of cells obtained by lavage of the pleural surfaces at the time of resection of non–small cell lung…”
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Hematopoietic stem cell origin of mesenchymal cells: opportunity for novel therapeutic approaches by Ogawa, Makio, LaRue, Amanda C., Watson, Patricia M., Watson, Dennis K.

“…There has been a general belief that there are two types of adult stem cells, i.e., hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), each…”
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Differential regulation of leptin expression and function in A/J vs. C57BL/6J mice during diet-induced obesity by Watson, P M, Commins, S P, Beiler, R J, Hatcher, H C, Gettys, T W

“…Obesity-resistant (A/J) and obesity-prone (C57BL/6J) mice were weaned onto low-fat (LF) or high-fat (HF) diets and studied after 2, 10, and 16 wk. Despite…”
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Leptin selectively reduces white adipose tissue in mice via a UCP1-dependent mechanism in brown adipose tissue by Commins, S P, Watson, P M, Frampton, I C, Gettys, T W

“…We tested the hypothesis that leptin, in addition to reducing body fat by restraining food intake, reduces body fat through a peripheral mechanism requiring…”
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Complementary feature selection from alternative splicing events and gene expression for phenotype prediction by Labuzzetta, Charles J, Antonio, Margaret L, Watson, Patricia M, Wilson, Robert C, Laboissonniere, Lauren A, Trimarchi, Jeffrey M, Genc, Baris, Ozdinler, P Hande, Watson, Dennis K, Anderson, Paul E

“…A central task of bioinformatics is to develop sensitive and specific means of providing medical prognoses from biomarker patterns. Common methods to predict…”
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Hematopoietic stem cell origin of adipocytes by Sera, Yasuhiko, LaRue, Amanda C, Moussa, Omar, Mehrotra, Meenal, Duncan, James D, Williams, Christopher R, Nishimoto, Eishi, Schulte, Bradley A, Watson, Patricia M, Watson, Dennis K, Ogawa, Makio

“…Objective It has generally been believed that adipocytes are derived from mesenchymal stem cells via fibroblasts. We recently reported that…”
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Multivariate models from RNA-Seq SNVs yield candidate molecular targets for biomarker discovery: SNV-DA by Paul, Matt R, Levitt, Nicholas P, Moore, David E, Watson, Patricia M, Wilson, Robert C, Denlinger, Chadrick E, Watson, Dennis K, Anderson, Paul E

“…It has recently been shown that significant and accurate single nucleotide variants (SNVs) can be reliably called from RNA-Seq data. These may provide another…”
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Hematopoietic stem cell origin of connective tissues by Ogawa, Makio, LaRue, Amanda C, Watson, Patricia M, Watson, Dennis K

“…Connective tissue consists of “connective tissue proper,” which is further divided into loose and dense (fibrous) connective tissues and “specialized…”
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CaSm (LSm-1) Overexpression in Lung Cancer and Mesothelioma Is Required for Transformed Phenotypes by Watson, Patricia M, Miller, Scott W, Fraig, Mostafa, Cole, David J, Watson, Dennis K, Boylan, Alice M

“…CaSm (cancer-associated Sm-like) was originally identified based on elevated expression in pancreatic cancer and in several cancer-derived cell lines. It…”
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Differential Mechanisms and Development of Leptin Resistance in A/J Versus C57BL/6J Mice during Diet-Induced Obesity by Prpic, Veronica, Watson, Patricia M, Frampton, Isabell C, Sabol, Mark A, Jezek, G. Eric, Gettys, Thomas W

“…Changes in the biological efficacy of leptin were evaluated in obesity-resistant (A/J) and obesity-prone (C57BL/6J) mice at weaning and after consuming a…”
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Prostate-Derived ETS Factor Regulates Epithelial-to-Mesenchymal Transition through Both SLUG-Dependent and Independent Mechanisms by Findlay, Victoria J, Turner, David P, Yordy, John S, McCarragher, Brent, Shriver, Marey R, Szalai, Gabor, Watson, Patricia M, Larue, Amanda C, Moussa, Omar, Watson, Dennis K

“…The 5-year survival rate is very low when breast cancer becomes metastatic. The metastatic process is governed by a network of molecules of which SLUG is known…”
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Induction of Uncoupling Protein Expression in Brown and White Adipose Tissue by LeptinThis work was supported by a research grant from the American Diabetes Association, USPHS Grant DK-53981, and a research grant from the USDA (NRICGP/USDA 9800699) by Commins, Scott P., Watson, Patricia M., Padgett, Mark A., Dudley, Andrew, Argyropoulos, George, Gettys, Thomas W.

“…Deposition of excess body fat occurs when energy intake chronically exceeds energy expenditure. In ob/ob mice, the absence of leptin affects both components of…”
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Casm-mediated cellular transformation is associated with altered gene expression and messenger RNA stability by FRASER, Melissa M, WATSON, Patricia M, FRAIG, Mostafa M, KELLEY, Joseph R, NELSON, Peter S, BOYLAN, Alice M, COLE, David J, WATSON, Dennis K

“…CaSm (cancer-associated Sm-like) was originally identified based on elevated expression in pancreatic cancer and in several cancer-derived cell lines. CaSm…”
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Alternative Splicing in Prostate and Breast Cancer by Watson, Patricia M., Watson, Dennis K.

“…Alternative splicing of mRNA precursors allows the synthesis of multiple mRNAs from a single primary transcript, thus contributing to proteomic diversity in…”
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ETS Transcription Factor Expression and Conversion During Prostate and Breast Cancer Progression by Watson, Dennis K., Turner, David P., Scheiber, Melissa N., Findlay, Victoria J., Watson, Patricia M.

“…ETS factors are known to act as positive or negative regulators of the expression of genes including those that control response to various signaling cascades,…”
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