Search Results - "Watson, Lewis"

Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors by Pironti, Gianluigi, Strachan, Ryan T, Abraham, Dennis, Mon-Wei Yu, Samuel, Chen, Minyong, Chen, Wei, Hanada, Kenji, Mao, Lan, Watson, Lewis J, Rockman, Howard A

“…Whether biomechanical force on the heart can induce exosome secretion to modulate cardiovascular function is not known. We investigated the secretion and…”
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High fat feeding in mice is insufficient to induce cardiac dysfunction and does not exacerbate heart failure by Brainard, Robert E, Watson, Lewis J, Demartino, Angelica M, Brittian, Kenneth R, Readnower, Ryan D, Boakye, Adjoa Agyemang, Zhang, Deqing, Hoetker, Joseph David, Bhatnagar, Aruni, Baba, Shahid Pervez, Jones, Steven P

“…Preclinical studies of animals with risk factors, and how those risk factors contribute to the development of cardiovascular disease and cardiac dysfunction,…”
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The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction by Abraham, Dennis M, Lee, Teresa E, Watson, Lewis J, Mao, Lan, Chandok, Gurangad, Wang, Hong-Gang, Frangakis, Stephan, Pitt, Geoffrey S, Shah, Svati H, Wolf, Matthew J, Rockman, Howard A

“…Cardiac two-pore domain potassium channels (K2P) exist in organisms from Drosophila to humans; however, their role in cardiac function is not known. We…”
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Augmented O-GlcNAc signaling attenuates oxidative stress and calcium overload in cardiomyocytes by Ngoh, Gladys A, Watson, Lewis J, Facundo, Heberty T, Jones, Steven P

“…O-linked β-N-acetylglucosamine (O-GlcNAc) is an inducible, dynamically cycling and reversible post-translational modification of Ser/Thr residues of…”
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Metabolomic analysis of pressure-overloaded and infarcted mouse hearts by Sansbury, Brian E, DeMartino, Angelica M, Xie, Zhengzhi, Brooks, Alan C, Brainard, Robert E, Watson, Lewis J, DeFilippis, Andrew P, Cummins, Timothy D, Harbeson, Matthew A, Brittian, Kenneth R, Prabhu, Sumanth D, Bhatnagar, Aruni, Jones, Steven P, Hill, Bradford G

“…Cardiac hypertrophy and heart failure are associated with metabolic dysregulation and a state of chronic energy deficiency. Although several disparate changes…”
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O-GlcNAc signaling is essential for NFAT-mediated transcriptional reprogramming during cardiomyocyte hypertrophy by Facundo, Heberty T, Brainard, Robert E, Watson, Lewis J, Ngoh, Gladys A, Hamid, Tariq, Prabhu, Sumanth D, Jones, Steven P

“…The regulation of cardiomyocyte hypertrophy is a complex interplay among many known and unknown processes. One specific pathway involves the phosphatase…”
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MicroRNA-539 Is Up-regulated in Failing Heart, and Suppresses O-GlcNAcase Expression by Muthusamy, Senthilkumar, DeMartino, Angelica M., Watson, Lewis J., Brittian, Kenneth R., Zafir, Ayesha, Dassanayaka, Sujith, Hong, Kyung U., Jones, Steven P.

“…Derangements in metabolism and related signaling pathways characterize the failing heart. One such signal, O-linked β-N-acetylglucosamine (O-GlcNAc), is an…”
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O-linked β-N-acetylglucosamine transferase is indispensable in the failing heart by Watson, Lewis J, Facundo, Heberty T, Ngoh, Gladys A, Ameen, Mohamed, Brainard, Robert E, Lemma, Kewakebt M, Long, Bethany W, Prabhu, Sumanth D, Xuan, Yu-Ting, Jones, Steven P

“…The failing heart is subject to elevated metabolic demands, adverse remodeling, chronic apoptosis, and ventricular dysfunction. The interplay among such…”
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Play Your Way to an "A": Helping Students Engage During the Social Isolation of Remote Learning by Brainard, Robert Eli, Shaffer, Amy L, Watson, Lewis J, Terson de Paleville, Daniela G L, Falcone, Jeff C

“…One hurdle that educators are presented with is that the classroom is no longer limited to a physical location but rather students and professor can meet via…”
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Cardiomyocyte Ogt is essential for postnatal viability by Watson, Lewis J, Long, Bethany W, DeMartino, Angelica M, Brittian, Kenneth R, Readnower, Ryan D, Brainard, Robert E, Cummins, Timothy D, Annamalai, Lakshmanan, Hill, Bradford G, Jones, Steven P

“…The singly coded gene O-linked-β-N-acetylglucosamine (O-GlcNAc) transferase (Ogt) resides on the X chromosome and is necessary for embryonic stem cell…”
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Reduced cardiac fructose 2,6 bisphosphate increases hypertrophy and decreases glycolysis following aortic constriction by Wang, Jianxun, Xu, Jianxiang, Wang, Qianwen, Brainard, Robert E, Watson, Lewis J, Jones, Steven P, Epstein, Paul N

“…This study was designed to test whether reduced levels of cardiac fructose-2,6-bisphosphate (F-2,6-P(2)) exacerbates cardiac damage in response to pressure…”
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Adapting COVID-19 Contact Tracing Protocols to Accommodate Resource Constraints, Philadelphia, Pennsylvania, USA, 2021 by Jeon, Seonghye, Watson-Lewis, Lydia, Rainisch, Gabriel, Chiu, Chu-Chuan, Castonguay, François M, Fischer, Leah S, Moonan, Patrick K, Oeltmann, John E, Adhikari, Bishwa B, Lawman, Hannah, Meltzer, Martin I

“…Because of constrained personnel time, the Philadelphia Department of Public Health (Philadelphia, PA, USA) adjusted its COVID-19 contact tracing protocol in…”
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Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation by Watson, Lewis J, Alexander, Kevin M, Mohan, Maradumane L, Bowman, Amber L, Mangmool, Supachoke, Xiao, Kunhong, Naga Prasad, Sathyamangla V, Rockman, Howard A

“…β2-Adrenergic receptors (β2AR) transactivate epidermal growth factor receptors (EGFR) through formation of a β2AR-EGFR complex that requires activation of Src…”
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Cardiac overexpression of 8-oxoguanine DNA glycosylase 1 protects mitochondrial DNA and reduces cardiac fibrosis following transaortic constriction by Wang, Jianxun, Wang, Qianwen, Watson, Lewis J, Jones, Steven P, Epstein, Paul N

“…Cardiac failure is associated with increased levels of oxidized DNA, especially mitochondrial (mtDNA). It is not known if oxidized mtDNA contributes to cardiac…”
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Non-canonical glycosyltransferase modulates post-hypoxic cardiac myocyte death and mitochondrial permeability transition by Ngoh, Gladys A, Watson, Lewis J, Facundo, Heberty T, Dillmann, Wolfgang, Jones, Steven P

“…Abstract O-linked β- N -acetylglucosamine ( O -GlcNAc) is a dynamic, inducible, and reversible post-translational modification of nuclear and cytoplasmic…”
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The Inverted Case Study Technique: Changing the Traditional Case-Study Approach to Prioritize Physiological Mechanisms Over Correct Diagnosis and Treatment by Brainard, Robert E, Terson de Paleville, Daniela G L, Long, Michael C, Hughes, Daniel G, Watson, Lewis J, Anderson, Gary

“…The traditional case study has been used as a learning tool for the past 100 years and in our program, graduate physiology students are presented with a…”
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Cardiomyocyte Ogt limits ventricular dysfunction in mice following pressure overload without affecting hypertrophy by Dassanayaka, Sujith, Brainard, Robert E., Watson, Lewis J., Long, Bethany W., Brittian, Kenneth R., DeMartino, Angelica M., Aird, Allison L., Gumpert, Anna M., Audam, Timothy N., Kilfoil, Peter J., Muthusamy, Senthilkumar, Hamid, Tariq, Prabhu, Sumanth D., Jones, Steven P.

“…The myocardial response to pressure overload involves coordination of multiple transcriptional, posttranscriptional, and metabolic cues. The previous studies…”
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XPS Analysis of Submicrometer Barium Titanate Powder by Wegmann, Markus, Watson, Lewis, Hendry, Alan

“…A commercial submicrometer BaTiO3 powder was analyzed using X‐ray photoelectron spectroscopy. The analysis revealed the powder surfaces to be covered with a…”
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Cardiomyocyte Ogt limits ventricular dysfunction in mice following pressure overload without affecting hypertrophy by Dassanayaka, Sujith, Brainard, Robert E., Watson, Lewis J., Long, Bethany W., Brittian, Kenneth R., DeMartino, Angelica M., Aird, Allison L., Gumpert, Anna M., Audam, Timothy N., Kilfoil, Peter J., Muthusamy, Senthilkumar, Hamid, Tariq, Prabhu, Sumanth D., Jones, Steven P.

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Cardiac phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia by Wang, Qianwen, Donthi, Rajakumar V, Wang, Jianxun, Lange, Alex J, Watson, Lewis J, Jones, Steven P, Epstein, Paul N

“…During ischemia and heart failure, there is an increase in cardiac glycolysis. To understand if this is beneficial or detrimental to the heart, we chronically…”
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