Search Results - "Watson, Kal"

Positive pressure ventilation compresses pulmonary acinar microvessels but not their supply vessels by Conhaim, Robert L., Segal, Gilad S., Watson, Kal E.

“…Pulmonary alveolar septal capillaries receive their perfusion from a web of larger surrounding acinar vessels. Using 4 μm diam. Latex particles, we showed that…”
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Apnea causes microvascular perfusion maldistribution in isolated rat lungs by Conhaim, Robert L., Watson, Kal E., Broytman, Oleg, Teodorescu, Mihaela

“…Obstructive sleep apnea is associated with significant cardiovascular disease, yet little is known about the effects of OSA on pulmonary microvascular…”
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Characterising the gut microbiome in veterans with Gulf War Illness: a protocol for a longitudinal, prospective cohort study by Keating, Julie A, Shaughnessy, Catherine, Baubie, Kelsey, Kates, Ashley E, Putman-Buehler, Nathan, Watson, Lauren, Dominguez, Nadia, Watson, Kal, Cook, Dane B, Rabago, David, Suen, Garret, Gangnon, Ronald, Safdar, Nasia

“…IntroductionApproximately 25%–35% of the 1991 Gulf War Veteran population report symptoms consistent with Gulf War Illness (GWI), a chronic, multi-symptom…”
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Negative pressure ventilation enhances acinar perfusion in isolated rat lungs by Watson, Kal E., Segal, Gilad S., Conhaim, Robert L.

“…We compared acinar perfusion in isolated rat lungs ventilated using positive or negative pressures. The lungs were ventilated with air at transpulmomary…”
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Evidence for active control of perfusion within lung microvessels by WATSON, Kal E, DOVI, William F, CONHAIM, Robert L

“…Vasoconstrictors cause contraction of pulmonary microvascular endothelial cells in culture. We wondered if this meant that contraction of these cells in situ…”
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Inhaled Thrombolytics Reduce Lung Microclot and Leukocyte Infiltration After Acute Blood Loss by Conhaim, Robert L, Watson, Kal E, Dovi, William F, Bates, Melissa L

“…ABSTRACTWe showed previously that a 30% blood loss in rats, without resuscitation, caused significant accumulation of microthrombi and leukocytes within the…”
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Arterio‐venous anastomoses in isolated, perfused rat lungs by Conhaim, Robert L., Segal, Gilad S., Watson, Kal E.

“…Several studies have suggested that large‐diameter (>25 μm) arterio‐venous shunt pathways exist in the lungs of rats, dogs, and humans. We investigated the…”
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Microthrombus formation may trigger lung injury after acute blood loss by Conhaim, Robert L, Mangino, Martin J, Dovi, William F, Watson, Kal E, Warner, Thomas F, Harms, Bruce A

“…We showed previously that acute blood loss, without resuscitation, caused marked maldistribution of interalveolar perfusion. Because hemorrhage is a known risk…”
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Bacteremic sepsis disturbs alveolar perfusion distribution in the lungs of rats by Conhaim, Robert L, Watson, Kal E, Spiegel, Carol A, Dovi, William F, Harms, Bruce A

“…OBJECTIVE:Sepsis often leads to lung injury, although the mechanisms that initiate this are unclear. One preinjury phenomenon that has not been explored…”
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Hemorrhage progressively disturbs interalveolar perfusion in the lungs of rats by Conhaim, Robert L, Kluesner, Karri A, Watson, Kal E, Munoz-del-Rio, Alejandro, Heisey, Dennis M, Harms, Bruce A

“…Acute hemorrhage is often followed by devastating lung injury. However, why blood loss should lead to lung injury is not known. One possibility is that…”
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Bacteremia Does Not Affect Cellular Uptake of Ultrafine Particles in the Lungs of Rats by Conhaim, Robert L., Dovi, William F., Watson, Kal E., Spiegel, Carol A., Harms, Bruce A.

“…To assess the effects of intra‐abdominal bacteremia on lung cellular function in vivo, we used electron microscopy to quantify the uptake of 6 nm diameter,…”
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Acute hypoxia does not alter inter-alveolar perfusion distribution in unanesthetized rats by Conhaim, Robert L, Burt Olson, E, Vidruk, Edward H, Watson, Kal E, Heisey, Dennis M, Leverson, Glen E, Harms, Bruce A

“…Abstract Effects of hypoxic vasoconstriction on inter-alveolar perfusion distribution (≤1000 alveoli) have not been studied. To address this, we measured…”
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Perfusion heterogeneity in rat lungs assessed from the distribution of 4-μm-diameter latex particles by CONHAIM, Robert L, WATSON, Kal E, HEISEY, Dennis M, LEVERSON, Glen E, HARMS, Bruce A

“…Pulmonary vascular perfusion has been shown to follow a fractal distribution down to a resolution of 0.5 cm 3 (5E11 μm 3 ). We wanted to know whether this…”
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Thromboxane receptor analog, U-46619, redistributes pulmonary microvascular perfusion in isolated rat lungs by Conhaim, Robert L, Watson, Kal E, Heisey, Dennis M, Leverson, Glen E, Harms, Bruce A

“…Department of Surgery, University of Wisconsin-Madison, Madison 53792-7375; and The William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin…”
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Transport properties of alveolar epithelium measured by molecular hetastarch absorption in isolated rat lungs by Conhaim, Robert L, Watson, Kal E, Lai-Fook, Stephen J, Harms, Bruce A

“…1  Department of Surgery, University of Wisconsin-Madison, The William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53792-7375; and 2  Center…”
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Immunogenicity of trimethoprim‐sulfamethoxazole in SIV‐infected rhesus macaques by Wong, Yat Yee, Watson, Kal, Trepanier, Lauren

“…Abstract only HIV infected patients have a high risk of hypersensitivity (HS) reactions to trimethoprim/sulfamethoxazole (TMP/SMX). To understand this, simian…”
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Acellular hemoglobin solution enters compressed lung capillaries more readily than red blood cells by Conhaim, Robert L, Rodenkirch, Lance A, Watson, Kal E, Harms, Bruce A

“…Department of Surgery, University of Wisconsin-Madison, and William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705 High lung inflation…”
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EXPRESS: Negative Pressure Ventilation Enhances Acinar Perfusion in Isolated Rat Lungs by Watson, Kal E, Segal, Gilad S, Conhaim, Robert L

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Embolization with 10, 15 and 50 micrometer spheres recruits intrapulmonary shunt vessels in isolated rat lungs by Bates, Melissa, Watson, Kal, Eldridge, Marlowe

“…Abstract only We hypothesized that intrapulmonary shunt vessels (IPAVs) are present in the rat, located in the lung apex, and are recruited by increased…”
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Thromboxane analog U46619 redistributes pulmonary microvascular perfusion in isolated rat lungs, but does not retain 3 μm diameter particles in lung capillaries by Conhaim, Robert L., Watson, Kal A., Dovi, William F., Harms, Bruce A.

“…Abstract only U46619 is a potent vasoconstrictor that increases vascular resistance 2–4 fold in isolated, perfused rat lungs. We wondered if any of this…”
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