Search Results - "Watson, Erica D."

Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development by Padmanabhan, Nisha, Jia, Dongxin, Geary-Joo, Colleen, Wu, Xuchu, Ferguson-Smith, Anne C., Fung, Ernest, Bieda, Mark C., Snyder, Floyd F., Gravel, Roy A., Cross, James C., Watson, Erica D.

“…The importance of maternal folate consumption for normal development is well established, yet the molecular mechanism linking folate metabolism to development…”
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Placental glycogen stores and fetal growth: insights from genetic mouse models by Tunster, Simon J, Watson, Erica D, Fowden, Abigail L, Burton, Graham J

“…The placenta performs a range of crucial functions that support fetal growth during pregnancy, including facilitating the supply of oxygen and nutrients to the…”
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Transferring Fragments of Paternal Metabolism to the Offspring by Watson, Erica D.

“…Paternal diet influences offspring metabolism, yet the underlying epigenetic mechanisms are unclear. Recently, Chen et al. (2016) and Sharma et al. (2016)…”
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Development of Structures and Transport Functions in the Mouse Placenta by Watson, Erica D, Cross, James C

“…Erica D. Watson and James C. Cross Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada…”
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Variably methylated retrotransposons are refractory to a range of environmental perturbations by Bertozzi, Tessa M., Becker, Jessica L., Blake, Georgina E. T., Bansal, Amita, Nguyen, Duy K., Fernandez-Twinn, Denise S., Ozanne, Susan E., Bartolomei, Marisa S., Simmons, Rebecca A., Watson, Erica D., Ferguson-Smith, Anne C.

“…The agouti viable yellow ( A vy ) allele is an insertional mutation in the mouse genome caused by a variably methylated intracisternal A particle (VM-IAP)…”
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Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker by Blake, Georgina E. T., Zhao, Xiaohui, Yung, Hong wa, Burton, Graham J., Ferguson-Smith, Anne C., Hamilton, Russell S., Watson, Erica D.

“…The mechanism behind transgenerational epigenetic inheritance is unclear, particularly through the maternal grandparental line. We previously showed that…”
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Suppression of mitochondrial electron transport chain function in the hypoxic human placenta: a role for miRNA-210 and protein synthesis inhibition by Colleoni, Francesca, Padmanabhan, Nisha, Yung, Hong-Wa, Watson, Erica D, Cetin, Irene, Tissot van Patot, Martha C, Burton, Graham J, Murray, Andrew J

“…Fetal growth is critically dependent on energy metabolism in the placenta, which drives active exchange of nutrients. Placental oxygen levels are therefore…”
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Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction by Yung, Hong wa, Hemberger, Myriam, Watson, Erica D, Senner, Claire E, Jones, Carolyn P, Kaufman, Randal J, Charnock-Jones, D Stephen, Burton, Graham J

“…We recently reported the first evidence of placental endoplasmic reticulum (ER) stress in the pathophysiology of human intrauterine growth restriction. Here,…”
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One-carbon metabolism is required for epigenetic stability in the mouse placenta by Senner, Claire E, Dong, Ziqi, Prater, Malwina, Branco, Miguel R, Watson, Erica D

“…One-carbon metabolism, including the folate cycle, has a crucial role in fetal development though its molecular function is complex and unclear. The…”
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Disruption of Folate Metabolism Causes Poor Alignment and Spacing of Mouse Conceptuses for Multiple Generations by Wilkinson, Amy L, Menelaou, Katerina, Rakoczy, Joanna, Tan, Xiu S, Watson, Erica D

“…Abnormal uptake or metabolism of folate increases risk of human pregnancy complications, though the mechanism is unclear. Here, we explore how defective folate…”
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Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice by Sowton, Alice P., Padmanabhan, Nisha, Tunster, Simon J., McNally, Ben D., Murgia, Antonio, Yusuf, Aisha, Griffin, Julian L., Murray, Andrew J., Watson, Erica D.

“…Nonalcoholic fatty liver disease (NAFLD) is associated with dietary folate deficiency and mutations in genes required for one‑carbon metabolism. However, the…”
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Folate-depletion alters mouse trophoblast stem cell regulation in vitro by Rakoczy, Joanna, Watson, Erica D

“…Maternal folate deficiency increases risk of congenital malformations, yet its effect on placenta development is unclear. Here, we investigated how…”
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The Mrj co-chaperone mediates keratin turnover and prevents the formation of toxic inclusion bodies in trophoblast cells of the placenta by Watson, Erica D., Geary-Joo, Colleen, Hughes, Martha, Cross, James C.

“…Defects in protein-folding and -degradation machinery have been identified as a major cause of intracellular protein aggregation and of aggregation-associated…”
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Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase by Elmore, C. Lee, Wu, Xuchu, Leclerc, Daniel, Watson, Erica D., Bottiglieri, Teodoro, Krupenko, Natalia I., Krupenko, Sergey A., Cross, James C., Rozen, Rima, Gravel, Roy A., Matthews, Rowena G.

“…Hyperhomocyst(e)inemia is a metabolic derangement that is linked to the distribution of folate pools, which provide one-carbon units for biosynthesis of…”
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Branching morphogenesis during development of placental villi by Cross, James C., Nakano, Haruo, Natale, David R.C., Simmons, David G., Watson, Erica D.

“…The placenta forms a complex interface between the mother and fetus during development that is designed for efficient nutrient exchange. A large surface area…”
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Unravelling the complex mechanisms of transgenerational epigenetic inheritance by Blake, Georgina ET, Watson, Erica D

“…[Display omitted] •Epigenetic information can be altered by environmental stressors.•The mechanisms of epigenetic inheritance are complex and unclear.•DNA and…”
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Chorioallantoic Morphogenesis and Formation of the Placental Villous Tree by CROSS, JAMES C., SIMMONS, DAVID G., WATSON, ERICA D.

“…: The placenta is a highly specialized organ whose primary function is to promote the exchange of nutrients and oxygen between maternal and fetal blood,…”
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Excessive endoplasmic reticulum stress drives aberrant mouse trophoblast differentiation and placental development leading to pregnancy loss by Capatina, Nadejda, Hemberger, Myriam, Burton, Graham J., Watson, Erica D., Yung, Hong Wa

“…Key points Endoplasmic reticulum (ER) stress promotes placental dysmorphogenesis and is associated with poor pregnancy outcomes. We show that unfolded protein…”
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Fat eggs shape offspring health by Watson, Erica D, Rakoczy, Joanna

“…How maternal diet influences offspring metabolism is unclear, as it is difficult to distinguish between the effects of the in utero environment and epigenetic…”
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Lessons from the one-carbon metabolism: passing it along to the next generation by Padmanabhan, Nisha, Watson, Erica D

“…Abstract During development, a fetus and its placenta must respond to a changing maternal environment to ensure normal growth is achieved and survival is…”
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