Search Results - "Watson, Emma E."

Biosupramolecular networks: Taking inspiration from nature to create powerful synthetic platforms by Watson, Emma E., Winssinger, Nicolas

“…Nature is predicated on the ability to process large number of parallel signals to produce specific downstream outputs. Biosupramolecular networks are…”
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Exploiting Chemical Protein Synthesis to Study the Role of Tyrosine Sulfation on Anticoagulants from Hematophagous Organisms by Maxwell, Joshua W. C., Hawkins, Paige M. E., Watson, Emma E., Payne, Richard J.

“…Conspectus Tyrosine sulfation is a post-translational modification (PTM) that modulates function by mediating key protein–protein interactions. One of the…”
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Synthesis of Protein-Oligonucleotide Conjugates by Watson, Emma E, Winssinger, Nicolas

“…Nucleic acids and proteins form two of the key classes of functional biomolecules. Through the ability to access specific protein-oligonucleotide conjugates, a…”
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Expressed Protein Selenoester Ligation by Kulkarni, Sameer S., Watson, Emma E., Maxwell, Joshua W. C., Niederacher, Gerhard, Johansen‐Leete, Jason, Huhmann, Susanne, Mukherjee, Somnath, Norman, Alexander R., Kriegesmann, Julia, Becker, Christian F. W., Payne, Richard J.

“…Herein, we describe the development and application of a novel expressed protein selenoester ligation (EPSL) methodology for the one‐pot semi‐synthesis of…”
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Site-selective photocatalytic functionalization of peptides and proteins at selenocysteine by Dowman, Luke J., Kulkarni, Sameer S., Alegre-Requena, Juan V., Giltrap, Andrew M., Norman, Alexander R., Sharma, Ashish, Gallegos, Liliana C., Mackay, Angus S., Welegedara, Adarshi P., Watson, Emma E., van Raad, Damian, Niederacher, Gerhard, Huhmann, Susanne, Proschogo, Nicholas, Patel, Karishma, Larance, Mark, Becker, Christian F. W., Mackay, Joel P., Lakhwani, Girish, Huber, Thomas, Paton, Robert S., Payne, Richard J.

“…The importance of modified peptides and proteins for applications in drug discovery, and for illuminating biological processes at the molecular level, is…”
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Rapid assembly and profiling of an anticoagulant sulfoprotein library by Watson, Emma E., Ripoll-Rozada, Jorge, Lee, Ashley C., Wu, Mike C. L., Franck, Charlotte, Pasch, Tim, Premdjee, Bhavesh, Sayers, Jessica, Pinto, Maria F., Martins, Pedro M., Jackson, Shaun P., Pereira, Pedro José Barbosa, Payne, Richard J.

“…Hematophagous organisms produce a suite of salivary proteins which interact with the host’s coagulation machinery to facilitate the acquisition and digestion…”
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Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis by Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng Ruh, Linington, Roger G., Mahapatra, Sebabrata, Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Timothy D. H., Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J., Payne, Richard J.

“…Tuberculosis (TB) is responsible for enormous global morbidity and mortality, and current treatment regimens rely on the use of drugs that have been in use for…”
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Biosupramolecular Systems: Integrating Cues into Responses by Watson, Emma E, Angerani, Simona, Sabale, Pramod M, Winssinger, Nicolas

“…Life is orchestrated by biomolecules interacting in complex networks of biological circuitry with emerging function. Progress in different areas of chemistry…”
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Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics by Watson, Emma E., Liu, Xuyu, Thompson, Robert E., Ripoll-Rozada, Jorge, Wu, Mike, Alwis, Imala, Gori, Alessandro, Loh, Choy-Theng, Parker, Benjamin L., Otting, Gottfried, Jackson, Shaun, Pereira, Pedro José Barbosa, Payne, Richard J.

“…The anophelins are small protein thrombin inhibitors that are produced in the salivary glands of the Anopheles mosquito to fulfill a vital role in blood…”
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Photocatalysis in Chemical Biology: Extending the Scope of Optochemical Control and Towards New Frontiers in Semisynthetic Bioconjugates and Biocatalysis by Liu, Weilong, Watson, Emma E., Winssinger, Nicolas

“…Biomedical research has been empowered by tools that enable spatial and temporal control of biological systems. These have predominantly come from photocaged…”
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Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization by Watson, Emma E., Russo, Francesco, Moreau, Dimitri, Winssinger, Nicolas

“…A Ru(bpy)3Cl2 photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene‐containing pharmacological agents, including combretastatin…”
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Peptide Nucleic Acids: From Origami to Editing by Carson, Liam M., Watson, Emma E.

“…Peptide nucleic acids (PNAs) combine the programmability of native nucleic acids with the robustness and ease of synthesis of a peptide backbone. These…”
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Rapid Synthesis of Propargyl‐γ‐Modified Peptide Nucleic Acid Monomers for Late‐Stage Functionalization of Oligomers by López‐Tena, Miguel, Watson, Emma E., Romanens, Patrick, Winssinger, Nicolas

“…The exceptional hybridization properties of peptide nucleic acids (PNAs) coupled with the ease of their synthesis has made this artificial nucleic acid mimetic…”
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Total Synthesis of Glycosylated Human Interferon‑γ by Wang, Xiaoyi, Ashhurst, Anneliese S, Dowman, Luke J, Watson, Emma E, Li, Henry Y, Fairbanks, Antony J, Larance, Mark, Kwan, Ann, Payne, Richard J

“…Interferon-γ (IFN-γ) is a glycoprotein that is responsible for orchestrating numerous critical immune induction and modulation processes and is used clinically…”
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Total Synthesis of the Spider-Venom Peptide Hi1a by Duggan, Nisharnthi M, Saez, Natalie J, Clayton, Daniel, Budusan, Elena, Watson, Emma E, Tucker, Isaac J, Rash, Lachlan D, King, Glenn F, Payne, Richard J

“…Hi1a is a venom peptide from the Australian funnel-web spider Hadronyche infensa with a complex tertiary structure. Hi1a has neuroprotective and…”
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Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods by Agten, Stijn M., Watson, Emma E., Ripoll‐Rozada, Jorge, Dowman, Luke J., Wu, Mike C. L., Alwis, Imala, Jackson, Shaun P., Pereira, Pedro José Barbosa, Payne, Richard J.

“…Blood feeding arthropods, such as leeches, ticks, flies and mosquitoes, provide a privileged source of peptidic anticoagulant molecules. These primarily…”
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Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization by Watson, Emma E., Russo, Francesco, Moreau, Dimitri, Winssinger, Nicolas

“…A Ru(bpy)3Cl2 photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene‐containing pharmacological agents, including combretastatin…”
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Titelbild: Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization (Angew. Chem. 28/2022) by Watson, Emma E., Russo, Francesco, Moreau, Dimitri, Winssinger, Nicolas

“…Die photokatalytische Isomerisierung von Wirkstoffmolekülen mit Ru(bpy3)2 ist Thema des Forschungsartikels von Nicolas Winssinger et al. (e202203390). Es wird…”
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Diselenide–selenoester ligation for chemical protein synthesis by Kulkarni, Sameer S., Watson, Emma E., Premdjee, Bhavesh, Conde-Frieboes, Kilian W., Payne, Richard J.

“…Chemoselective peptide ligation methods have provided synthetic access to numerous proteins, including those bearing native post-translational modifications…”
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A simple linearization method unveils hidden enzymatic assay interferences by Pinto, Maria Filipa, Ripoll-Rozada, Jorge, Ramos, Helena, Watson, Emma E., Franck, Charlotte, Payne, Richard J., Saraiva, Lucília, Pereira, Pedro José Barbosa, Pastore, Annalisa, Rocha, Fernando, Martins, Pedro M.

“…Enzymes are among the most important drug targets in the pharmaceutical industry. The bioassays used to screen enzyme modulators can be affected by unaccounted…”
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