Search Results - "Watson, Donald"

Cross-Coupling of Heteroatomic Electrophiles by Korch, Katerina M, Watson, Donald A

“…At the advent of cross-coupling chemistry, carbon electrophiles based on halides or pseudohalides were the only suitable electrophilic coupling partners…”
Get full text

Synthesis of Axially Chiral 2,2′-Bisphosphobiarenes via a Nickel-Catalyzed Asymmetric Ullmann Coupling: General Access to Privileged Chiral Ligands without Optical Resolution by Zuo, Ziqing, Kim, Raphael S, Watson, Donald A

“…We report an asymmetric homocoupling of ortho-(iodo)­aryl­phosphine oxides and ortho-(iodo)­aryl­phosphonates resulting in highly enantio­enriched axially…”
Get full text

Nickel-Catalyzed Asymmetric C‑Alkylation of Nitroalkanes: Synthesis of Enantioenriched β‑Nitroamides by Devannah, Vijayarajan, Sharma, Rajgopal, Watson, Donald A

“…A general catalytic method for asymmetric C-alkylation of nitroalkanes using nickel catalysis is described. This method enables the formation of highly…”
Get full text

Nickel-Catalyzed C‑Alkylation of Nitroalkanes with Unactivated Alkyl Iodides by Rezazadeh, Sina, Devannah, Vijayarajan, Watson, Donald A

“…Enabled by nickel catalysis, a mild and general catalytic method for C-alkylation of nitroalkanes with unactivated alkyl iodides is described. Compatible with…”
Get full text

Palladium-Catalyzed Cross-Coupling of Silyl Electrophiles with Alkylzinc Halides: A Silyl-Negishi Reaction by Cinderella, Andrew P, Vulovic, Bojan, Watson, Donald A

“…We report the first example of a silyl-Negishi reaction between secondary zinc organometallics and silicon electrophiles. This palladium-catalyzed process…”
Get full text

Palladium-Catalyzed Trifluoromethylation of Aryl Chlorides by Cho, Eun Jin, Senecal, Todd D, Kinzel, Tom, Zhang, Yong, Watson, Donald A, Buchwald, Stephen L

“…The trifluoromethyl group can dramatically influence the properties of organic molecules, thereby increasing their applicability as pharmaceuticals,…”
Get full text

Heck‐Like Reactions Involving Heteroatomic Electrophiles by Vulovic, Bojan, Watson, Donald A.

“…Since the discovery of the Heck reaction in the early seventies, the reaction has become a powerful tool in synthetic organic chemistry. By employing…”
Get full text

Synthesis of Indolines and Derivatives by Aza‐Heck Cyclization by Xu, Feiyang, Korch, Katerina M., Watson, Donald A.

“…For the first time, an aza‐Heck cyclization that allows the preparation of indoline scaffolds is described. Using N‐hydroxy anilines as electrophiles, which…”
Get full text

Palladium-Catalyzed Cross-Coupling of Monochlorosilanes and Grignard Reagents by Vulovic, Bojan, Cinderella, Andrew P, Watson, Donald A

“…Using a palladium catalyst supported by DrewPhos, the alkylation of monochlorosilanes with primary and secondary alkylmagnesium halides is now possible…”
Get full text

Synthesis of N−H Bearing Imidazolidinones and Dihydroimidazolones Using Aza‐Heck Cyclizations by Xu, Feiyang, Shuler, Scott A., Watson, Donald A.

“…The synthesis of unsaturated, unprotected imidazolidinones via an aza‐Heck reaction is described. This palladium‐catalyzed process allows for the cyclization…”
Get full text

Synthesis of Trisubstituted Alkenyl Boronic Esters from Alkenes Using the Boryl-Heck Reaction by Reid, William B, Watson, Donald A

“…The direct borylation of disubstituted alkenes is reported. These conditions allow for the conversion of a variety 1,1- and 1,2-disubstituted alkenes to…”
Get full text

A Highly Active Catalyst for Pd-Catalyzed Amination Reactions: Cross-Coupling Reactions Using Aryl Mesylates and the Highly Selective Monoarylation of Primary Amines Using Aryl Chlorides by Fors, Brett P, Watson, Donald A, Biscoe, Mark R, Buchwald, Stephen L

“…A catalyst system based on a new biarylmonophosphine ligand (BrettPhos) that shows excellent reactivity for C−N cross-coupling reactions is reported. This…”
Get full text

Tandem aza-Heck Suzuki and carbonylation reactions of O -phenyl hydroxamic ethers: complex lactams via carboamination by Gao, Run-Duo, Shuler, Scott A, Watson, Donald A

“…The palladium-catalysed tandem aza-Heck-Suzuki and aza-Heck-carbonylation reactions of -phenyl hydroxamic ethers are reported. These formal alkene…”
Get full text

Direct Synthesis of Alkenyl Boronic Esters from Unfunctionalized Alkenes: A Boryl-Heck Reaction by Reid, William B, Spillane, Jesse J, Krause, Sarah B, Watson, Donald A

“…We report the first example of a boryl-Heck reaction using an electrophilic boron reagent. This palladium-catalyzed process allows for the conversion of…”
Get full text

Formation of ArF from LPdAr(F): Catalytic Conversion of Aryl Triflates to Aryl Fluorides by Watson, Donald A., Su, Mingjuan, Teverovskiy, Georgiy, Zhang, Yong, García-Fortanet, Jorge, Kinzel, Tom, Buchwald, Stephen L.

“…Despite increasing pharmaceutical importance, fluorinated aromatic organic molecules remain difficult to synthesize. Present methods require either harsh…”
Get full text

Enantioselective Synthesis of Axially Chiral Biaryls by the Pd-Catalyzed Suzuki−Miyaura Reaction: Substrate Scope and Quantum Mechanical Investigations by Shen, Xiaoqiang, Jones, Gavin O, Watson, Donald A, Bhayana, Brijesh, Buchwald, Stephen L

“…We report efficient syntheses of axially chiral biaryl amides in yields ranging from 80−92%, and with enantioselectivity in the range 88−94% ee employing an…”
Get full text

Synthesis of Secondary Unsaturated Lactams via an Aza-Heck Reaction by Shuler, Scott A, Yin, Guoyin, Krause, Sarah B, Vesper, Caroline M, Watson, Donald A

“…The preparation of unsaturated secondary lactams via the palladium-catalyzed cyclization of O-phenyl hydroxamates onto a pendent alkene is reported. This…”
Get full text

Total Synthesis of (±)-Impatien A via Aza-Heck Cyclization by Korch, Katerina M, Watson, Donald A

“…The first total synthesis of the natural product impatien A is described. This concise synthesis features an aza-Heck cyclization to construct the complex…”
Get full text

Preparation of Vinyl Silyl Ethers and Disiloxanes via the Silyl-Heck Reaction of Silyl Ditriflates by Martin, Sara E. S., Watson, Donald A.

“…Vinyl silyl ethers and disiloxanes can now be prepared from aryl-substituted alkenes and related substrates using a silyl-Heck reaction. The reaction employs a…”
Get full text

Palladium-Catalyzed Aminocarbonylation of Aryl Chlorides at Atmospheric Pressure: The Dual Role of Sodium Phenoxide by Martinelli, Joseph R, Clark, Thomas P, Watson, Donald A, Munday, Rachel H, Buchwald, Stephen L

“…No pressure, no worries: A general, functional‐group‐tolerant, mild system for the Pd‐catalyzed carbonylation of aryl chlorides to the corresponding amides has…”
Get full text