Search Results - "Watson, CJ"

Regulation of surface and soluble TNF receptor expression on human monocytes and synovial fluid macrophages by IL-4 and IL-10 by Hart, PH, Hunt, EK, Bonder, CS, Watson, CJ, Finlay-Jones, JJ

“…By regulating monocyte and macrophage production of IL-1, its receptor, and its receptor antagonist, IL-4 and IL-10 may exert significant anti-inflammatory…”
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The Multifaceted Role of STAT3 in Mammary Gland Involution and Breast Cancer by Hughes, Katherine, Watson, Christine J

“…Since seminal descriptions of signal transducer and activator of transcription 3 (STAT3) as a signal transducer and transcriptional regulator, which is most…”
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Key stages in mammary gland development - Involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ by Watson, Christine J

“…Involution of the mammary gland is an essential process that removes the milk-producing epithelial cells when they become redundant at weaning. It is a…”
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In Vivo Measurements of Neurotransmitters by Microdialysis Sampling by Watson, Christopher J, Venton, B. Jill, Kennedy, Robert T

“…The brain contains a vast network of neurons that connect with each other at specialized junctions called synapses.A synapse consists of a presynaptic terminal…”
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Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses by Zhu, Jinfang, Min, Booki, Hu-Li, Jane, Watson, Cynthia J, Grinberg, Alex, Wang, Qi, Killeen, Nigel, Urban, Jr, Joseph F, Guo, Liying, Paul, William E

“…Expression of the transcription factor GATA-3 is strongly associated with T helper type 2 (T(H)2) differentiation, but genetic evidence for its involvement in…”
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Spatial and temporal variations in groundwater nitrate at an intensive dairy farm in south-east Ireland: Insights from stable isotope data by Baily, A., Rock, L., Watson, C.J., Fenton, O.

“…► Stable isotopes of nitrate (δ 15N and δ 18O) can be used for differentiation of source and process. ► Time lag between nutrient application and groundwater…”
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Family-based eHealth interventions to reduce cardiovascular disease risk: a systematic review by Kemp, B, Thompson, DR, Mc Guigan, K, Watson, CJ, Woodside, JV, Ski, CF

“…Abstract Funding Acknowledgements Type of funding sources: Other. Main funding source(s): Department for the Economy, Northern Ireland Background Family-based…”
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Modelling spatial and inter-annual variations of nitrous oxide emissions from UK cropland and grasslands using DailyDayCent by Fitton, N., Datta, A., Cloy, J.M., Rees, R.M., Topp, C.F.E., Bell, M.J., Cardenas, L.M., Williams, J., Smith, K., Thorman, R., Watson, C.J., McGeough, K.L., Kuhnert, M., Hastings, A., Anthony, S., Chadwick, D., Smith, P.

“…•Spatial variation in N2O emissions can be ascribed to soil texture or crop type.•Inter-annual variations for grasslands can be attributed to climate…”
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Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression by Clarkson, Richard W E, Wayland, Matthew T, Lee, Jennifer, Freeman, Tom, Watson, Christine J

“…In order to gain a better understanding of the molecular processes that underlie apoptosis and tissue regression in mammary gland, we undertook a large-scale…”
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Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores by Watson, Christopher J, Hoare, Catherine J, Garrod, David R, Carlson, Gordon L, Warhurst, Geoffrey

“…Impairment of the gut epithelial barrier by agents such as IFNgamma may play a key role in the pathogenesis of inflammatory disorders by increasing the…”
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IDENTIFICATION OF POLYMORPHISMS WITHIN THE VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) GENE: CORRELATION WITH VARIATION IN VEGF PROTEIN PRODUCTION by Watson, Carolyn J, Webb, Nicholas J.A, Bottomley, Martyn J, Brenchley, Paul E.C

“…Dysregulated vascular endothelial growth factor (VEGF) expression has been implicated as a major contributor to the development of a number of common disease…”
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Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomers by Watson, C J, Rowland, M, Warhurst, G

“…Despite significant advances in the characterization of tight junction (TJ) proteins, little is known about how molecular changes relate to function due…”
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The effects of oral garlic on vaginal candida colony counts: a randomised placebo controlled double‐blind trial by Watson, CJ, Grando, D, Fairley, CK, Chondros, P, Garland, SM, Myers, SP, Pirotta, M

“…Objective Garlic is effective against Candida species in vitro, and along with other alternative therapies, is used by women with vulvovaginal candidiasis. The…”
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High-throughput automated post-processing of separation data by Shackman, Jonathan G, Watson, Christopher J, Kennedy, Robert T

“…The development of an efficient method for high-throughput analysis of multiple electropherograms or chromatograms collected in series is presented. The…”
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The Genes Induced by Signal Transducer and Activators of Transcription (STAT)3 and STAT5 in Mammary Epithelial Cells Define the Roles of these STATs in Mammary Development by Clarkson, Richard W. E, Boland, Marion P, Kritikou, Ekaterini A, Lee, Jennifer M, Freeman, Tom C, Tiffen, Paul G, Watson, Christine J

“…Prolactin and leukemia inhibitory factor (LIF) have different roles in the adult mammary gland, which are mediated in part by the signal transducers and…”
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A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland by Kritikou, Ekaterini A, Sharkey, Andrew, Abell, Kathrine, Came, Paul J, Anderson, Elizabeth, Clarkson, Richard W E, Watson, Christine J

“…STAT3 is the key mediator of apoptosis in mammary gland. We demonstrate here that LIF is the physiological activator of STAT3, because in involuting mammary…”
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Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation by VanHouten, Joshua N, Dann, Pamela, Stewart, Andrew F, Watson, Christine J, Pollak, Michael, Karaplis, Andrew C, Wysolmerski, John J

“…Large amounts of calcium are transferred to offspring by milk. This demand results in negative calcium balance in lactating mothers and is associated with…”
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Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3 by Chapman, R S, Lourenco, P C, Tonner, E, Flint, D J, Selbert, S, Takeda, K, Akira, S, Clarke, A R, Watson, C J

“…Mammary gland involution is characterized by extensive apoptosis of the epithelial cells. At the onset of involution, Stat3 is specifically activated. To…”
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Stat6 Is Necessary and Sufficient for IL-4's Role in Th2 Differentiation and Cell Expansion by Zhu, Jinfang, Guo, Liying, Watson, Cynthia J, Hu-Li, Jane, Paul, William E

“…IL-4 plays a critical role in the differentiation of TCR-stimulated naive CD4 T cells to the Th2 phenotype. In response to IL-4, the IL-4R activates a set of…”
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Aptamer affinity chromatography for rapid assay of adenosine in microdialysis samples collected in vivo by Deng, Qing, Watson, Christopher J., Kennedy, Robert T.

“…An anti-adenosine aptamer was evaluated as a stationary phase in packed capillary liquid chromatography. Using an aqueous mobile phase containing 20 m M Mg 2+,…”
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