Search Results - "Watson, Annie"
-
1
Frataxin deficiency promotes endothelial senescence in pulmonary hypertension
Published in The Journal of clinical investigation (01-06-2021)“…The dynamic regulation of endothelial pathophenotypes in pulmonary hypertension (PH) remains undefined. Cellular senescence is linked to PH with intracardiac…”
Get full text
Journal Article -
2
Directed, efficient, and versatile modifications of the Drosophila genome by genomic engineering
Published in Proceedings of the National Academy of Sciences - PNAS (19-05-2009)“…With the completion of genome sequences of major model organisms, increasingly sophisticated genetic tools are necessary for investigating the complex and…”
Get full text
Journal Article -
3
Suggested avenues to reduce the stigma of mental illness in the Middle East
Published in International journal of social psychiatry (01-03-2015)“…Background: Stigma toward mentally ill individuals acts as a barrier to accessing care and receiving treatment. Aim: To review current evidence pertaining to…”
Get full text
Journal Article -
4
Exposure to herpes simplex virus type 1 and cognitive impairments in individuals with schizophrenia
Published in Schizophrenia bulletin (01-11-2012)“…Latent infection with neurotropic herpes viruses, such as herpes simplex virus, type 1 (HSV1), has been generally considered benign in most immunocompetent…”
Get full text
Journal Article -
5
Inflammatory Macrophage Expansion in Pulmonary Hypertension Depends upon Mobilization of Blood-Borne Monocytes
Published in The Journal of immunology (1950) (15-05-2018)“…Pulmonary inflammation, which is characterized by the presence of perivascular macrophages, has been proposed as a key pathogenic driver of pulmonary…”
Get full text
Journal Article -
6
Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells
Published in PloS one (27-11-2012)“…Human cytomegalovirus (HCMV) infection is one of the leading prenatal causes of congenital mental retardation and deformities world-wide. Access to cultured…”
Get full text
Journal Article -
7
W::Neo: a novel dual-selection marker for high efficiency gene targeting in Drosophila
Published in PloS one (13-02-2012)“…We have recently developed a so-called genomic engineering approach that allows for directed, efficient and versatile modifications of Drosophila genome by…”
Get full text
Journal Article -
8
Efficient Ends-Out Gene Targeting In Drosophila
Published in Genetics (Austin) (01-09-2008)“…In this report, we describe several approaches to improve the scalability and throughput of major genetic crosses in ends-out gene targeting. We generated new…”
Get full text
Journal Article -
9
Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension
Published in Science advances (22-10-2021)“…Cancer therapies are being considered for treating rare noncancerous diseases like pulmonary hypertension (PH), but effective computational screening is…”
Get full text
Journal Article -
10
HLA associations in schizophrenia: Are we re-discovering the wheel?
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (01-01-2014)“…ABSTRACT Associations between human leukocyte antigen (HLA) polymorphisms on chromosome 6p and schizophrenia (SZ) risk have been evaluated for over five…”
Get full text
Journal Article -
11
Correction: Human Induced Pluripotent Stem Cell-Derived Models to Investigate Human Cytomegalovirus Infection in Neural Cells
Published in PloS one (01-01-2014)Get full text
Journal Article -
12
Consanguinity and increased risk for schizophrenia in Egypt
Published in Schizophrenia research (01-07-2010)“…Abstract Background Consanguinity has been suggested as a risk factor for psychoses in some Middle Eastern countries, but adequate control data are…”
Get full text
Journal Article -
13
Evaluation of HLA polymorphisms in relation to schizophrenia risk and infectious exposure
Published in Schizophrenia bulletin (01-11-2012)“…Genome-wide association studies (GWAS) implicate single nucleotide polymorphisms (SNPs) on chromosome 6p21.3-22.1, the human leukocyte antigen (HLA) region, as…”
Get full text
Journal Article -
14
Distinct plasma gradients of microRNA-204 in the pulmonary circulation of patients suffering from WHO Groups I and II pulmonary hypertension
Published in Pulmonary circulation (01-04-2019)“…Pulmonary hypertension (PH), a heterogeneous vascular disease, consists of subtypes with overlapping clinical phenotypes. MicroRNAs, small non-coding RNAs that…”
Get full text
Journal Article -
15
Association tests of striatal DAT availability and SNPs that impact a novel splice variant in the DAT gene
Published in Journal of Nuclear Medicine (01-05-2012)“…The alternative splicing incorporates multiple stop codons that cause early truncation of the DAT open reading frame and are expected to trigger…”
Get full text
Journal Article -
16
Family Poverty and the Passive Curriculum of Care: Stories From Unhoused Families and Insights From K-12 Educators
Published 01-01-2023“…This qualitative study examines the material conditions and day-to-day realities of youth and family homelessness in the context of widespread economic…”
Get full text
Dissertation -
17
Abstract 17196: Genetic and Acquired DHCR7 Deficiency Upregulates 7β-hydroxycholesterol to Drive Endothelial Apoptosis and Pulmonary Hypertension
Published in Circulation (New York, N.Y.) (07-11-2023)“…Abstract only Introduction: Pulmonary hypertension (PH) is a fatal disease without a cure, in which endothelial dysfunction drives pathologic remodeling of the…”
Get full text
Journal Article -
18
Abstract 9770: Endothelial Loss of Amphiregulin Drives Inflammation and Endothelial Apoptosis in Pulmonary Hypertension
Published in Circulation (New York, N.Y.) (16-11-2021)“…Pulmonary hypertension (PH) is a vascular disease characterized by elevated pulmonary arterial pressure (PAP), leading to right ventricular failure and death…”
Get full text
Journal Article -
19
Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension
Published in Cellular & molecular immunology (01-02-2021)“…Myeloid cells, such as neutrophils, are produced in the bone marrow in high quantities and are important in the pathogenesis of vascular diseases such as…”
Get full text
Journal Article -
20
Engineered Recombinant Hagfish Intermediate Filament Proteins: Unraveling Domain Roles in Synthetic Fiber Formation and Mechanics
Published in ACS omega (14-11-2024)Get full text
Journal Article