Search Results - "Watnick, Randolph S"

PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression by Sui, Lufei, Wang, Suming, Ganguly, Debolina, El Rayes, Tyler P., Askeland, Cecilie, Børretzen, Astrid, Sim, Danielle, Halvorsen, Ole Johan, Knutsvik, Gøril, Arnes, Jarle, Aziz, Sura, Haukaas, Svein, Foulkes, William D., Bielenberg, Diane R., Ziemys, Arturas, Mittal, Vivek, Brekken, Rolf A., Akslen, Lars A., Watnick, Randolph S.

“…The progression of cancer from localized to metastatic disease is the primary cause of morbidity and mortality. The interplay between the tumor and its…”
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CCL5 derived from platelets increases megakaryocyte proplatelet formation by Machlus, Kellie R., Johnson, Kelly E., Kulenthirarajan, Rajesh, Forward, Jodi A., Tippy, Mason D., Soussou, Thomas S., El-Husayni, Saleh H., Wu, Stephen K., Wang, Suming, Watnick, Randolph S., Italiano, Joseph E., Battinelli, Elisabeth M.

“…In times of physiological stress, platelet count can transiently rise. What initiates this reactive thrombocytosis is poorly understood. Intriguingly, we found…”
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Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression by Godar, Samuel, Ince, Tan A., Bell, George W., Feldser, David, Donaher, Joana Liu, Bergh, Jonas, Liu, Anne, Miu, Kevin, Watnick, Randolph S., Reinhardt, Ferenc, McAllister, Sandra S., Jacks, Tyler, Weinberg, Robert A.

“…The p53 tumor suppressor is a key mediator of cellular responses to various stresses. Here, we show that under conditions of basal physiologic and cell-culture…”
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Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer by Straume, Oddbjørn, Shimamura, Takeshi, Lampa, Michael J. G, Carretero, Julian, Øyan, Anne M, Jia, Di, Borgman, Christa L, Soucheray, Margaret, Downing, Sean R, Short, Sarah M, Kang, Soo-Young, Wang, Souming, Chen, Liang, Collett, Karin, Bachmann, Ingeborg, Wong, Kwok-Kin, Shapiro, Geoffrey I, Kalland, Karl Henning, Folkman, Judah, Watnick, Randolph S, Akslen, Lars A, Naumov, George N

“…The mechanisms underlying tumor dormancy have been elusive and not well characterized. We recently published an experimental model for the study of human tumor…”
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Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1 by Catena, Raúl, Bhattacharya, Nandita, El Rayes, Tina, Wang, Suming, Choi, Hyejin, Gao, Dingcheng, Ryu, Seongho, Joshi, Natasha, Bielenberg, Diane, Lee, Sharrell B, Haukaas, Svein A, Gravdal, Karsten, Halvorsen, Ole J, Akslen, Lars A, Watnick, Randolph S, Mittal, Vivek

“…Metastatic tumors have been shown to establish permissive microenvironments for metastases via recruitment of bone marrow-derived cells. Here, we show that…”
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A Model of Human Tumor Dormancy: An Angiogenic Switch From the Nonangiogenic Phenotype by Naumov, George N., Bender, Elise, Zurakowski, David, Kang, Soo-Young, Sampson, David, Flynn, Evelyn, Watnick, Randolph S., Straume, Oddbjorn, Akslen, Lars A., Folkman, Judah, Almog, Nava

“…Background: Microscopic human cancers can remain dormant for life. Tumor progression depends on sequential events, including a switch to the angiogenic…”
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First-in-human phase I dose escalation trial of the first-in-class tumor microenvironment modulator VT1021 in advanced solid tumors by Mahalingam, Devalingam, Harb, Wael, Patnaik, Amita, Bullock, Andrea, Watnick, Randolph S., Vincent, Melanie Y., Chen, Jian Jenny, Wang, Suming, Pestana, Harold, Chao, Judy, Mahoney, James, Cieslewicz, Michael, Watnick, Jing

“…Background VT1021 is a cyclic peptide that induces the expression of thrombospondin-1 (TSP-1) in myeloid-derived suppressor cells (MDSCs) recruited to the…”
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GRK3 is essential for metastatic cells and promotes prostate tumor progression by Li, Wenliang, Ai, Nanping, Wang, Suming, Bhattacharya, Nandita, Vrbanac, Vladimir, Collins, Michael, Signoretti, Sabina, Hu, Yanhui, Boyce, Frederick M., Gravdal, Karsten, Halvorsen, Ole J., Nalwoga, Hawa, Akslen, Lars A., Ed Harlow, Watnick, Randolph S.

“…The biochemical mechanisms that regulate the process of cancer metastasis are still poorly understood. Because kinases, and the signaling pathways they…”
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A paradoxical method to enhance compensatory lung growth: Utilizing a VEGF inhibitor by Dao, Duy T, Anez-Bustillos, Lorenzo, Jabbouri, Sahir S, Pan, Amy, Kishikawa, Hiroko, Mitchell, Paul D, Fell, Gillian L, Baker, Meredith A, Watnick, Randolph S, Chen, Hong, Rogers, Michael S, Bielenberg, Diane R, Puder, Mark

“…Exogenous vascular endothelial growth factor (VEGF) accelerates compensatory lung growth (CLG) in mice after unilateral pneumonectomy. In this study, we…”
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Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1 by Kang, Soo-Young, Halvorsen, Ole J, Gravdal, Karsten, Bhattacharya, Nandita, Lee, Jung Min, Liu, Nathan W, Johnston, Brian T, Johnston, Adam B, Haukaas, Svein A, Aamodt, Kristie, Yoo, Sun, Akslen, Lars A, Watnick, Randolph S

“…Metastatic tumors can prepare a distant site for colonization via the secretion of factors that act in a systemic manner. We hypothesized that non- or weakly…”
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Phase 1 dose expansion and biomarker study assessing first-in-class tumor microenvironment modulator VT1021 in patients with advanced solid tumors by Chen, Jian Jenny, Vincent, Melanie Y., Shepard, Dale, Peereboom, David, Mahalingam, Devalingam, Battiste, James, Patel, Manish R., Juric, Dejan, Wen, Patrick Y., Bullock, Andrea, Selfridge, Jennifer Eva, Pant, Shubham, Liu, Joyce, Li, Wendy, Fyfe, Susanne, Wang, Suming, Zota, Victor, Mahoney, James, Watnick, Randolph S., Cieslewicz, Michael, Watnick, Jing

“…Background Preclinical studies have demonstrated that VT1021, a first-in-class therapeutic agent, inhibits tumor growth via stimulation of thrombospondin-1…”
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Reactive Oxygen Signaling and MAPK Activation Distinguish Epstein-Barr Virus (EBV)-Positive versus EBV-Negative Burkitt's Lymphoma by Cerimele, Francesca, Battle, Traci, Lynch, Rebecca, Frank, David A., Murad, Emma, Cohen, Cynthia, MacAron, Nada, Sixbey, John, Smith, Kenneth, Watnick, Randolph S., Eliopoulos, Aristidis, Shehata, Bahig, Arbiser, Jack L., Wallace, Douglas C.

“…Burkitt's lymphoma (BL) is an aggressive B cell neoplasm, which is one of the most common neoplasms of childhood. It is highly widespread in East Africa, where…”
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Spontaneous reversion of the angiogenic phenotype to a nonangiogenic and dormant state in human tumors by Rogers, Michael S, Novak, Katherine, Zurakowski, David, Cryan, Lorna M, Blois, Anna, Lifshits, Eugene, Bø, Trond H, Oyan, Anne M, Bender, Elise R, Lampa, Michael, Kang, Soo-Young, Naxerova, Kamila, Kalland, Karl-Henning, Straume, Oddbjorn, Akslen, Lars A, Watnick, Randolph S, Folkman, Judah, Naumov, George N

“…The angiogenic switch, a rate-limiting step in tumor progression, has already occurred by the time most human tumors are detectable. However, despite…”
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Ras Modulates Myc Activity to Repress Thrombospondin-1 Expression and Increase Tumor Angiogenesis by Watnick, Randolph S., Cheng, Yi-Ning, Rangarajan, Annapoorni, Ince, Tan A., Weinberg, Robert A.

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The role of the tumor microenvironment in regulating angiogenesis by Watnick, Randolph S

“…The tumor-associated stroma has been shown to play a significant role in cancer formation. Paracrine signaling interactions between epithelial tumor cells and…”
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Regulation of tumor dormancy as a function of tumor-mediated paracrine regulation of stromal Tsp-1 and VEGF expression by KANG, SOO-YOUNG, WATNICK, RANDOLPH S

“…Tumor dormancy is a critical yet poorly understood phenomenon affecting both the diagnosis and treatment of human cancers. This is due in large part to the…”
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Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment by Wang, Suming, Blois, Anna, El Rayes, Tina, Liu, Joyce F, Hirsch, Michelle S, Gravdal, Karsten, Palakurthi, Sangeetha, Bielenberg, Diane R, Akslen, Lars A, Drapkin, Ronny, Mittal, Vivek, Watnick, Randolph S

“…The vast majority of ovarian cancer-related deaths are caused by metastatic dissemination of tumor cells, resulting in subsequent organ failure. However,…”
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Melanocyte pigmentation inversely correlates with MCP‐1 production and angiogenesis‐inducing potential by Adini, Irit, Adini, Avner, Bazinet, Lauren, Watnick, Randolph S., Bielenberg, Diane R., D'Amato, Robert J.

“…ABSTRACT The incidence of certain angiogenesis‐dependent diseases is higher in Caucasians than in African Americans. Angiogenesis is amplified in wound healing…”
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Heparin impairs angiogenic signaling and compensatory lung growth after left pneumonectomy by Dao, Duy T., Anez-Bustillos, Lorenzo, Ourieff, Jared, Pan, Amy, Mitchell, Paul D., Kishikawa, Hiroko, Fell, Gillian L., Baker, Meredith A., Watnick, Randolph S., Chen, Hong, Hamilton, Thomas E., Rogers, Michael S., Bielenberg, Diane R., Puder, Mark

“…Children with hypoplastic lung diseases, such as congenital diaphragmatic hernia, can require life support via extracorporeal membrane oxygenation and systemic…”
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Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis by Watnick, Randolph S, Cheng, Yi-Ning, Rangarajan, Annapoorni, Ince, Tan A, Weinberg, Robert A

“…Tumor angiogenesis is postulated to be regulated by the balance between pro- and anti-angiogenic factors. We demonstrate that the critical step in establishing…”
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