Search Results - "Watlington, C O"

When is cortisol a mineralocorticoid? by Clore, John, Schoolwerth, Anton, Watlington, Charles O.

“…(1) Decreased 11 beta-OHSD activity permits binding of cortisol to the Type I (mineralocorticoid) receptor in humans, thereby producing…”
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Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol by Hunt, C M, Watkins, P B, Saenger, P, Stave, G M, Barlascini, N, Watlington, C O, Wright, Jr, J T, Guzelian, P S

“…The N-demethylation of erythromycin and 6 beta-hydroxylation of cortisol are both functions of the glucocorticoid-inducible CYP3A in human liver microsomes. To…”
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Focus on "Aldosterone responsiveness of A6 cells is restored by cloned rat mineralocorticoid receptor" by Watlington, C O

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Corticosterone 6 beta-hydroxylation correlates with blood pressure in spontaneously hypertensive rats by Watlington, C O, Kramer, L B, Schuetz, E G, Zilai, J, Grogan, W M, Guzelian, P, Gizek, F, Schoolwerth, A C

“…Evidence for increased glucocorticoid 6 beta-hydroxylation (enhanced family 3A cytochrome P-450 activity) is found in certain reversible forms of human…”
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Renal and hepatic family 3A cytochromes P450 (CYP3a) in spontaneously hypertensive rats by Ghosh, Sidhartha S., Basu, Ashish K., Ghosh, Shobha, Hagley, Rodney, Kramer, Lora, Schuetz, John, Grogan, W.McLean, Guzelian, Philip, Watlington, Charles O.

“…Troleandomycin (TAO), a selective family 3A cytochromes P450 (CYP3A) inhibitor, decreases enhanced in vivo corticosterone 6β-hydroxylation and blood pressure…”
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Evidence that high dose cortisol-induced Na+ retention in man is not mediated by the mineralocorticoid receptor by Montrella-Waybill, M, Clore, J N, Schoolwerth, A C, Watlington, C O

“…We have previously shown that high dose cortisol (F; 240 mg/day)-induced Na+ retention and systolic blood pressure (BP) increases are not inhibited by the…”
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Corticosterone's metabolite is an agonist for Na+ transport stimulation in A6 cells by Duncan, R L, Grogan, W M, Kramer, L B, Watlington, C O

“…This study tests the hypothesis, in A6 epithelia, that 1) corticosterone stimulates active Na+ transport (short-circuit current, Isc) by an additional receptor…”
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Corticosterone 6 beta-hydroxylase in A6 epithelia: a steroid-inducible cytochrome P-450 by Grogan, W M, Phillips, V M, Schuetz, E G, Guzelian, P S, Watlington, C O

“…We found microsomal corticosterone 6 beta-hydroxylase (6 beta-OHase) from cultured A6 kidney epithelial cells to be a cytochrome P-450 enzyme with both…”
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Insulin and aldosterone interaction on NA+ and K+ transport in cultured kidney cells (A6) by Fidelman, M L, Watlington, C O

“…The effects of aldosterone (A) and insulin (I) on active Na+ transport [short circuit current (Isc)] and basolateral to apical K+ transport were evaluated in…”
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Aldosterone and corticosterone binding and effects on Na+ transport in cultured kidney cells by Watlington, C O, Perkins, F M, Munson, P J, Handler, J S

“…A continuous line of cells (A6) derived from toad kidney has been shown to form epithelia in culture that manifest aldosterone-stimulatable transepithelial…”
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Maternal environment defines blood pressure and its response to troleandomycin in spontaneously hypertensive rats by Basu, A K, Hagley, R D, Ghosh, S S, Kramer, L, Nance, W E, Watlington, C O

“…Relationship between family-3A cytochrome P-450-dependent (troleandomycin inhibitable) and maternal environmental-dependent systolic blood pressure (SBP) was…”
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Adrenocorticotropin and cortisol-induced changes in urinary sodium and potassium excretion in man: effects of spironolactone and RU486 by Clore, J N, Estep, H, Ross-Clunis, H, Watlington, C O

“…The role of the glucocorticoid (type II) receptor in the Na+ retention induced by cortisol is not known. The relative contribution of mineralocorticoid (type…”
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Insulin stimulation of Na+ transport and glucose metabolism in cultured kidney cells by Fidelman, M L, May, J M, Biber, T U, Watlington, C O

“…A line of toad kidney cells (A6) in continuous culture was evaluated for ion transport and metabolic responses to insulin. The cells were grown on permeable…”
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Effect of chronic adrenocorticotropin stimulation on the excretion of 18-hydroxycortisol and 18-oxocortisol by Gomez-Sanchez, C E, Clore, J N, Estep, H L, Watlington, C O

“…The human adrenal gland can metabolize cortisol to yield steroids oxygenated at the 18 position in a series of reactions similar to those by which…”
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Effect of aldosterone and insulin on mannitol, Na+ and Cl- fluxes in cultured epithelia of renal origin (A6): evidence for increased permeability in the paracellular pathway by Fidelman, M L, Watlington, C O

“…Transepithelial fluxes of mannitol, Na+ and Cl- were measured under open circuit conditions in cultured epithelia derived from toad kidney (A6). Both…”
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11 beta-Hydroxysteroid dehydrogenase activity in the renal target cells of aldosterone by Náray-Fejes-Tóth, A, Watlington, C O, Fejes-Tóth, G

“…Aldosterone selectivity in mineralocorticoid target tissues has been suggested to be due to 11 beta-hydroxysteroid dehydrogenase (11-OHSD), which, by…”
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The effect of adrenal steroid hormones on epithelia formed in culture by A6 cells by Handler, J S, Preston, A S, Perkins, F M, Matsumura, M, Johnson, J P, Watlington, C O

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Corticosterone is converted to 6 beta-hydroxycorticosterone in rat: effects of the metabolite on urinary electrolyte excretion by Watlington, C O, Atkins, J L, McNeil, J S, Grogan, W M, Johnson, J P

“…This study was performed to determine whether corticosterone (B), the major glucocorticoid of rat, is metabolized to its 6 beta-OH derivative (6 beta-OH-B) and…”
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The oral glucose tolerance test by Watlington, C O

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Effect of aldosterone on 86Rb fluxes in cultured kidney cells (A6) by FIDELMAN, M. K, DUNCAN, R. L, WATLINGTON, C. O

“…This study was designed to evaluate the relative contributions of hormone induced changes in active and passive K+ transport in an epithelial cell line in…”
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