Search Results - "Watling, K J"

Nonpeptide antagonists herald new era in tachykinin research by Watling, K J

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Stimulation of angiogenesis by substance P and interleukin‐1 in the rat and its inhibition by NK1 or interleukin‐1 receptor antagonists by Fan, Tai‐Ping D., Hu, De‐En, Guard, Steven, Gresham, G. Austin, Watling, Keith J.

“…1 Daily administration of 1 nmol substance P or 3 pmol recombinant human interleukin‐1 alpha (IL‐1α) caused intense neovascularization in a rat sponge model of…”
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The interaction of the NK1 receptor antagonist CP‐96,345 with L‐type calcium channels and its functional consequences by Guard, S., Boyle, S.J., Tang, K.‐W., Watling, K.J., McKnight, A.T., Woodruff, G.N.

“…1 We investigated the effects of the non‐peptide NK1 receptor antagonist, CP‐96,345, its inactive enantiomer CP‐96,344, and the racemic mixture (±)‐CP‐96,345,…”
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Pharmacological analysis of [3H]‐senktide binding to NK3 tachykinin receptors in guinea‐pig ileum longitudinal muscle‐myenteric plexus and cerebral cortex membranes by Guard, Steven, Watson, Stephen P., Maggio, John E., Too, H. Phon, Watling, Keith J.

“…1 The binding properties and pharmacological specificity of the selective NK3 tachykinin receptor agonist [3H]‐senktide ([3H]‐succinyl[Asp6,MePhe8] substance P…”
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purification and properties of myo-inositol monophosphatase from bovine brain by Gee, N.S, Ragan, C.I, Watling, K.J, Aspley, S, Jackson, R.G, Reid, G.G, Gani, D, Shute, J.K

“…1. An inositol monophosphatase was purified to homogeneity from bovine brain. 2. The enzyme is a dimer of subunit Mr 29,000. 3. The enzyme hydrolyses both…”
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Interaction of the atypical neuroleptic clozapine with 5-HT3 receptors in the cerebral cortex and superior cervical ganglion of the rat by Watling, K J, Beer, M S, Stanton, J A, Newberry, N R

“…Clozapine, an atypical neuroleptic drug devoid of extrapyramidal side effects, was a moderately potent, competitive inhibitor of the binding of [3H]quaternised…”
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Effects of tachykinins on inositol phospholipid hydrolysis in slices of hamster urinary bladder by Bristow, D.R., Curtis, N.R., Suman‐Chauhan, N., Watling, K.J., Williams, B.J.

“…1 Tachykinin‐stimulated inositol phospholipid hydrolysis was examined in slices of hamster urinary bladder. 2 In the presence of lithium, to inhibit inositol…”
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[125I]neurokinin A labels pharmacologically distinct populations of NK2 binding sites in hamster and rabbit urinary bladder by Guard, S, Pain, D, Franks, R, Watling, K J

“…The pharmacological profile of NK2 binding sites has been characterised in homogenates of rabbit urinary bladder and compared with that present in homogenates…”
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Neurokinin3‐receptors are linked to inositol phospholipid hydrolysis in the guinea‐pig ileum longitudinal muscle‐myenteric plexus preparation by Guard, S., Watling, K.J., Watson, S.P.

“…1 Tachykinin‐stimulated inositol phospholipid hydrolysis was examined in slices of longitudinal muscle from guinea‐pig ileum. 2 Substance P, neurokinin A and…”
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Pharmacological characterization of tachykinin‐stimulated inositol phospholipid hydrolysis in peripheral tissues by Suman‐Chauhan, N., Guard, S., Williams, B.J., Watling, K.J.

“…1 Tachykinin‐stimulated inositol phospholipid hydrolysis was examined in slices of rat parotid gland, hamster urinary bladder and guinea‐pig ileum longitudinal…”
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Species variants of tachykinin receptor types by Watling, K J, Guard, S, Boyle, S J, McKnight, A T, Woodruff, G N

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Stereospecific inhibition of dopamine-sensitive adenylate cyclase in carp retina by the enantiomers of (+/-)-1-cyclopropylmethyl-4-(3-trifluoro-methylthio-5H-dibenzo [a,d] cyclohepten-5-ylidene) piperidine (CTC) by Watling, K J

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Vasoactive Intestinal Peptide Alters Membrane Potential and Cyclic Nucleotide Levels in Retinal Horizontal Cells by Lasater, Eric M., Watling, Keith J., Dowling, John E.

“…Vasoactive intestinal peptide stimulated the synthesis of adenosine 3$^{\prime}$,5$^{\prime}$-monophosphate in fractions of isolated carp horizontal cells…”
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Aporphines. 34. (-)-2,10,11-Trihydroxy-N-n-propylnoraporphine, a novel dopaminergic aporphine alkaloid with anticonvulsant activity by Neumeyer, J. L, Law, S. J, Meldrum, B, Anlezark, G, Watling, K. J

“…(-)-2,10,11-Trihydroxy-N-n-propylnoraporphine (TNPA,2c) has been synthesized from thebaine (3a), via northebaine (3b), normorphothebaine (2a), and alkylation…”
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Direct effect of a nomifensine derivative on dopamine receptors by Poat, J A, Woodruff, G N, Watling, K J

“…A study was made of the effects of nomifensine, 4'-hydroxynomifensine and 3',4'-dihydroxynomifensine on dopamine receptors in rat striatum and nucleus…”
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The rising sun shines on substance P and related peptides by Watling, K J, Krause, J E

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Rational design of high affinity tachykinin NK2 receptor antagonists by Boyle, S, Guard, S, Hodgson, J, Horwell, D C, Howson, W, Hughes, J, McKnight, A, Martin, K, Pritchard, M C, Watling, K J

“…The rational discovery of a high affinity NK2 receptor antagonist is described utilizing a general strategy for peptoid design. The contribution to NK2…”
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[3H]quaternised ICS 205-930 labels 5-HT3 receptor binding sites in rat brain by Watling, K J, Aspley, S, Swain, C J, Saunders, J

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Pharmacological properties and localization of dopamine-sensitive adenylate cyclase in the carp retina by Van Buskirk, R, Watling, K J

“…There is a specific dopamine (DA)-sensitive adenylate cyclase (EC 4.6.1.1) in the carp retina that can be stimulated by DA, DA agonists, and potassium…”
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Evidence for two types of tachykinin receptors on cholinergic neurons of the guinea pig ileum myenteric plexus by Guard, S, McKnight, A T, Watling, K J, Watson, S P

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