Search Results - "Watkins SA"

January 2019 critical care case of the month: A 32-year-old woman with cardiac arrest by Watkins SA, Smelski G, French RNE, Insel M, Campion J

“…No abstract available. Article truncated after the first page. History of Present Illness: A 32-year-old woman with history of chronic neck pain and opioid…”
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Structure-based design of a new class of highly selective aminoimidazo[1,2- a]pyridine-based inhibitors of cyclin dependent kinases by Hamdouchi, Chafiq, Zhong, Boyu, Mendoza, Jose, Collins, Elizabeth, Jaramillo, Carlos, De Diego, Jose Eugenio, Robertson, Daniel, Spencer, Charles D., Anderson, Bryan D., Watkins, Scott A., Zhang, Faming, Brooks, Harold B.

“…Structure-based design approach was successfully used to design and discover new structural class of imidazopyridine as highly specific cyclin dependent kinase…”
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Kinetic Characterization of Novel Pyrazole TGF-β Receptor I Kinase Inhibitors and Their Blockade of the Epithelial−Mesenchymal Transition by Peng, Sheng-Bin, Yan, Lei, Xia, Xiaoling, Watkins, Scott A, Brooks, Harold B, Beight, Douglas, Herron, David K, Jones, Michael L, Lampe, John W, McMillen, William T, Mort, Nicholas, Sawyer, J. Scott, Yingling, Jonathan M

“…Transforming growth factor β (TGF-β) signaling pathways regulate a wide variety of cellular processes including cell proliferation, differentiation,…”
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Synthesis, Structure−Activity Relationship, and Biological Studies of Indolocarbazoles as Potent Cyclin D1-CDK4 Inhibitors by Zhu, Guoxin, Conner, Scott E, Zhou, Xun, Shih, Chuan, Li, Tiechao, Anderson, Bryan D, Brooks, Harold B, Campbell, Robert Morris, Considine, Eileen, Dempsey, Jack A, Faul, Margaret M, Ogg, Cathy, Patel, Bharvin, Schultz, Richard M, Spencer, Charles D, Teicher, Beverly, Watkins, Scott A

“…Novel substituted indolocarbazoles were synthesized, and their kinase inhibitory capability was evaluated in vitro. 6-Substituted indolocarbazoles 4 were found…”
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Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7- a]pyrrolo[3,4- c]carbazoles by Engler, Thomas A., Furness, Kelly, Malhotra, Sushant, Sanchez-Martinez, Concha, Shih, Chuan, Xie, Walter, Zhu, Guoxin, Zhou, Xun, Conner, Scott, Faul, Margaret M., Sullivan, Kevin A., Kolis, Stanley P., Brooks, Harold B., Patel, Bharvin, Schultz, Richard M., DeHahn, Tammy B., Kirmani, Kashif, Spencer, Charles D., Watkins, Scott A., Considine, Eileen L., Dempsey, Jack A., Ogg, Catherine A., Stamm, Nancy B., Anderson, Bryan D., Campbell, Robert M., Vasudevan, Vasu, Lytle, Michelle L.

“…The synthesis and CDK inhibitory properties of a series of indolo[6,7- a]pyrrolo[3,4- c]carbazoles is reported. In addition to their potent CDK activity, the…”
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Aminoimidazo[1,2- a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation by Jaramillo, Carlos, de Diego, J. Eugenio, Hamdouchi, Chafiq, Collins, Elizabeth, Keyser, Heather, Sánchez-Martı́nez, Concha, del Prado, Miriam, Norman, Bryan, Brooks, Harold B., Watkins, Scott A., Spencer, Charles D., Dempsey, Jack Alan, Anderson, Bryan D., Campbell, Robert M., Leggett, Tellie, Patel, Bharvin, Schultz, Richard M., Espinosa, Juan, Vieth, Michal, Zhang, Faming, Timm, David E.

“…Synthesis of 2-aminoimidazo[1,2- a]pyridines 1 and their evaluation as CDK2 inhibitors is described. We have identified a novel structural class of protein…”
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Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides by Sanchez-Martinez, Concha, Shih, Chuan, Zhu, Guoxin, Li, Tiechao, Brooks, Harold B, Patel, Bharvin K R, Schultz, Richard M, DeHahn, Tammy B, Spencer, Charles D, Watkins, Scott A, Ogg, Catherine A, Considine, Eileen, Dempsey, Jack A, Zhang, Faming

“…A series of indolo[2,3-a]pyrrolo[3,4-c]carbazoles and their bis-indolylmaleimides precursors have been prepared in order to compare their activity as D1-CDK4…”
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Synthesis of 1,7-annulated indoles and their applications in the studies of cyclin dependent kinase inhibitors by Zhu, Guoxin, Conner, Scott E., Zhou, Xun, Chan, Ho-Kit, Shih, Chuan, Engler, Thomas A., Al-awar, Rima S., Brooks, Harold B., Watkins, Scott A., Spencer, Charles D., Schultz, Richard M., Dempsey, Jack A., Considine, Eileen L., Patel, Bharvin R., Ogg, Catherine A., Vasudevan, Vasu, Lytle, Michelle L.

“…A novel series of 1,7-annulated indolocarbazoles was synthesized and their D1/CDK4 inhibitory and antiproliferative activity were evaluated. The synthesis of a…”
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Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors by SANCHEZ-MARTINEZ, Concha, SHIH, Chuan, BROOKS, Harold B, PATEL, Bharvin K. R, SCHULTZ, Richard M, DEHAHN, Tammy B, SPENCER, Charles D, WATKINS, Scott A, CONSIDINE, Eileen, DEMPSEY, Jack A, OGG, Catherine A, CAMPBELL, Robert M, FAUL, Margaret M, ANDERSON, Bryan A, WAGNER, Jill, GUOXIN ZHU, PAAL, Michael, SOMOZA, Carmen, TIECHAO LI, KUMRICH, Christine A, WINNEROSKI, Leonard L, ZHOU XUN

“…The synthesis of new analogues of Arcyriaflavin A in which one indole ring is replaced by an aryl or heteroaryl ring is described. These new series of…”
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Synthesis of quinolinyl/isoquinolinyl[ a]pyrrolo [3,4- c] carbazoles as cyclin D1/CDK4 inhibitors by Zhu, Guoxin, Conner, Scott, Zhou, Xun, Shih, Chuan, Brooks, Harold B., Considine, Eileen, Dempsey, Jack A., Ogg, Cathy, Patel, Bharvin, Schultz, Richard M., Spencer, Charles D., Teicher, Beverly, Watkins, Scott A.

“…A novel series of pyrrolo[3,4- c] carbazoles fused with a quinolinyl/isoquinolinyl moiety were synthesized and their D1/CDK4 inhibitory and antiproliferative…”
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Actin-containing sera from patients with adult respiratory distress syndrome are toxic to sheep pulmonary endothelial cells by ERUKHIMOV, J. A, TANG, Z.-L, JOHNSON, B. A, DONAHOE, M. P, RAZZACK, J. A, GIBSON, K. F, LEE, W. M, WASSERLOOS, K. J, WATKINS, S. A, PITT, B. R

“…Actin released from damaged cells after a variety of tissue injuries appears to be involved in multiple organ dysfunction syndrome. Under experimental…”
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The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines by Hamdouchi, Chafiq, Keyser, Heather, Collins, Elizabeth, Jaramillo, Carlos, De Diego, Jose Eugenio, Spencer, Charles D, Dempsey, Jack Alan, Anderson, Bryan D, Leggett, Tillie, Stamm, Nancy B, Schultz, Richard M, Watkins, Scott A, Cocke, Kim, Lemke, Stephanie, Burke, Teresa F, Beckmann, Richard P, Dixon, Jeffrey T, Gurganus, Thomas M, Rankl, Nancy B, Houck, Keith A, Zhang, Faming, Vieth, Michal, Espinosa, Juan, Timm, David E, Campbell, Robert M, Patel, Bharvin K R, Brooks, Harold B

“…The protein kinase family represents an enormous opportunity for drug development. However, the current limitation in structural diversity of kinase inhibitors…”
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Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells by Ceneviva, G D, Tzeng, E, Hoyt, D G, Yee, E, Gallagher, A, Engelhardt, J F, Kim, Y M, Billiar, T R, Watkins, S A, Pitt, B R

“…Our group recently reported that cultured sheep pulmonary artery endothelial cells (SPAECs) became resistant to lipopolysaccharide (LPS)-induced apoptosis…”
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1,7-Annulated indolocarbazoles as cyclin-dependent kinase inhibitors by Al-awar, Rima S., Ray, James E., Hecker, Kyle A., Huang, Jianping, Waid, Philip P., Shih, Chuan, Brooks, Harold B., Spencer, Charles D., Watkins, Scott A., Patel, Bharvin R., Stamm, Nancy B., Ogg, Catherine A., Schultz, Richard M., Considine, Eileen L., Faul, Margaret M., Sullivan, Kevin A., Kolis, Stanley P., Grutsch, John L., Joseph, Sajan

“…A series of novel 1,7-annulated indolocarbazoles was prepared and evaluated for kinase inhibitory activity. The synthesis and kinase inhibitory activity of a…”
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Robert A. Millikan Award Lecture (July 2001): Can “descriptive” end with “A”? by Watkins, Sallie A.

“…Recent reports on science achievement in the United States reveal that much work remains to be done if our students are to be competitive with those of other…”
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Lunar Ice: Adsorbed Water on Subsurface Polar Dust by Cocks, F.H, Klenk, P.A, Watkins, S.A, Simmons, W.N, Cocks, J.C, Cocks, E.E, Sussingham, J.C

“…Differential scanning calorimetry indicates that adsorbed water and goethite, a product of hydrated ilmenite, are thermally stable over geologic time in the…”
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Overexpression of metallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury by Pitt, B R, Schwarz, M, Woo, E S, Yee, E, Wasserloos, K, Tran, S, Weng, W, Mannix, R J, Watkins, S A, Tyurina, Y Y, Tyurin, V A, Kagan, V E, Lazo, J S

“…Metallothionein (MT) is a low-molecular-weight cysteine-rich protein with extensive metal binding capacity and potential nonenzymatic antioxidant activity…”
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Arsenic in Ground Water: A Review of Current Knowledge and Relation to the CALFED Solution Area with Recommendations for Needed Research by Welch, Alan H., Oremland, Ronald S., Davis, James A., Watkins, Sharon A.

“…Ground water with arsenic concentrations greater than the U.S. Environmental Protection Agency drinking water standard exists throughout much of the CALFED…”
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Retrovirus-mediated gene transfer in lungs of living fetal sheep by Pitt, B R, Schwarz, M A, Pilewski, J M, Nakayama, D, Mueller, G M, Robbins, P D, Watkins, S A, Albertine, K H, Bland, R D

“…In utero somatic gene transfer may be a useful therapeutic strategy for a variety of inherited disorders. In the present study, we demonstrate transgene…”
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Conditional transformation of rat embryo fibroblast cells by a cyclin D1-cdk4 fusion gene by NAGARAJA RAO, R, STAMM, N. B, JOHNSON, D, SKIDMORE, B. J, OTTO, K, KOVACEVIC, S, WATKINS, S. A, RUTHERFORD, P, LEMKE, S, COCKE, K, BECKMANN, R. P, HOUCK, K

“…Cyclin D1 gene overexpression is a frequent event in a number of human cancers. These observations have led to the suggestion that cyclin D1 alterations might…”
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