Search Results - "Watkins, W. S"

Genetic Similarities Within and Between Human Populations by Witherspoon, D. J, Wooding, S, Rogers, A. R, Marchani, E. E, Watkins, W. S, Batzer, M. A, Jorde, L. B

“…The proportion of human genetic variation due to differences between populations is modest, and individuals from different populations can be genetically more…”
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The Distribution of Human Genetic Diversity: A Comparison of Mitochondrial, Autosomal, and Y-Chromosome Data by Jorde, L.B., Watkins, W.S., Bamshad, M.J., Dixon, M.E., Ricker, C.E., Seielstad, M.T., Batzer, M.A.

“…We report a comparison of worldwide genetic variation among 255 individuals by using autosomal, mitochondrial, and Y-chromosome polymorphisms. Variation is…”
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Pharmacogenomics of 17‐alpha hydroxyprogesterone caproate for recurrent preterm birth: a case–control study by Manuck, TA, Watkins, WS, Esplin, MS, Biggio, J, Bukowski, R, Parry, S, Zhan, H, Huang, H, Andrews, W, Saade, G, Sadovsky, Y, Reddy, UM, Ilekis, J, Yandell, M, Varner, MW, Jorde, LB

“…Objective To compare maternal genotypes between women with and without significant prolongation of pregnancy in the setting of 17‐alpha hydroxyprogesterone…”
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Population genomics : a bridge from evolutionary history to genetic medicine by JORDE, L. B, WATKINS, W. S, BAMSHAD, M. J

“…Studies of human genetic variation are making contributions in several key areas. Evolutionary genetic studies yield critical clues about the histories of…”
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Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome by Bamshad, Michael, Lin, Robert C, Law, David J, Watkins, W. Scott, Krakowiak, Patrycja A, Moore, Mary E, Franceschini, Piergiorgio, Lala, Roberto, Holmes, Lewis B, Gebuhr, Tom C, Bruneau, Benoit G, Schinzel, Albert, Seidman, J. G, Seidman, Christine E, Jorde, Lynn B

“…Ulnar-mammary syndrome is a rare pleiotropic disorder affecting limb, apocrine gland, tooth and genital development. We demonstrate that mutations in human…”
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Patterns of Ancestral Human Diversity: An Analysis of Alu-Insertion and Restriction-Site Polymorphisms by Watkins, W.S., Ricker, C.E., Bamshad, M.J., Carroll, M.L., Nguyen, S.V., Batzer, M.A., Harpending, H.C., Rogers, A.R., Jorde, L.B.

“…We have analyzed 35 widely distributed, polymorphic Alu loci in 715 individuals from 31 world populations. The average frequency of Alu insertions (the derived…”
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DNA Sequence Variation in a 3.7-kb Noncoding Sequence 5′ of the CYP1A2 Gene: Implications for Human Population History and Natural Selection by Wooding, S.P., Watkins, W.S., Bamshad, M.J., Dunn, D.M., Weiss, R.B., Jorde, L.B.

“…CYP1A2 is a cytochrome P450 gene that is involved in human physiological responses to a variety of drugs and toxins. To investigate the role of population…”
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The Spectrum of Mutations in TBX3: Genotype/Phenotype Relationship in Ulnar-Mammary Syndrome by Bamshad, M., Le, T., Watkins, W.S., Dixon, M.E., Kramer, B.E., Roeder, A.D., Carey, J.C., Root, S., Schinzel, A., Van Maldergem, L., Gardner, R.J.M., Lin, R.C., Seidman, C.E., Seidman, J.G., Wallerstein, R., Moran, E., Sutphen, R., Campbell, C.E., Jorde, L.B.

“…Ulnar-mammary syndrome (UMS) is a pleiotropic disorder affecting limb, apocrine-gland, tooth, hair, and genital development. Mutations that disrupt the…”
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Deep common ancestry of Indian and western-Eurasian mitochondrial DNA lineages by Kivisild, T., Bamshad, M.J., Kaldma, K., Metspalu, M., Metspalu, E., Reidla, M., Laos, S., Parik, J., Watkins, W.S., Dixon, M.E., Papiha, S.S., Mastana, S.S., Mir, M.R., Ferak, V., Villems, R.

“…About a fifth of the human gene pool belongs largely either to Indo-European or Dravidic speaking people inhabiting the Indian peninsula. The ‘Caucasoid share’…”
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Origins and affinities of modern humans : a comparison of mitochondrial and nuclear genetic data by JORDE, L. B, BAMSHAD, M. J, WATKINS, W. S, ZENGER, R, FRALEY, A. E, KRAKOWIAK, P. A, CARPENTER, K. D, SOODYALL, H, JENKINS, T, ROGERS, A. R

“…To test hypotheses about the origin of modern humans, we analyzed mtDNA sequences, 30 nuclear restriction-site polymorphisms (RSPs), and 30 tetranucleotide…”
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Evolutionary history of the mtDNA 9-bp deletion in Chinese populations and its relevance to the peopling of east and southeast Asia by YAO, Yong-Gang, WATKINS, W. S, ZHANG, Ya-Ping

“…In total, 1218 Chinese from twelve ethnic groups and nine Han geographic groups were screened for the mtDNA 9-bp deletion motif. The frequency of the 9-bp…”
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Population genetics of trinucleotide repeat polymorphisms by Watkins, W S, Bamshad, M, Jorde, L B

“…Trinucleotide repeats at five disease loci (DM, DRPLA, HD, SBMA and SCA1) were surveyed in phenotypically normal individuals from three continental…”
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Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region by JORDE, L. B, WATKINS, W. S, CARLSON, M, GRODEN, J, ALBERTSEN, H, THLIVERIS, A, LEPPERT, M

“…To test the reliability of linkage-disequilibrium analysis for gene mapping, we compared physical distance and linkage disequilibrium among seven polymorphisms…”
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Female gene flow stratifies Hindu castes by Bamshad, Michael J, Watkins, W. Scott, Dixon, Mary E, Jorde, Lynn B, Rao, B. Bhaskara, Naidu, J. M, Prasad, B. V. Ravi, Rasanayagam, Arani, Hammer, Mike F

“…Scientists have long been interested in understanding how social processes modulate evolutionary forces. A good example of this is the intensively studied…”
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Crohn's Disease and Genetic Hitchhiking at IBD5 by Huff, Chad D., Witherspoon, David J., Zhang, Yuhua, Gatenbee, Chandler, Denson, Lee A., Kugathasan, Subra, Hakonarson, Hakon, Whiting, April, Davis, Chadwick T., Wu, Wilfred, Xing, Jinchuan, Watkins, W. Scott, Bamshad, Michael J., Bradfield, Jonathan P., Bulayeva, Kazima, Simonson, Tatum S., Jorde, Lynn B., Guthery, Stephen L.

“…Inflammatory bowel disease 5 (IBD5) is a 250 kb haplotype on chromosome 5 that is associated with an increased risk of Crohn's disease in Europeans. The OCTN1…”
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Multiple origins of the mtDNA 9-bp deletion in populations of South India by Watkins, W.S., Bamshad, M., Dixon, M.E., Bhaskara Rao, B., Naidu, J.M., Reddy, P.G., Prasad, B.V.R., Das, P.K., Reddy, P.C., Gai, P.B., Bhanu, A., Kusuma, Y.S., Lum, J.K., Fischer, P., Jorde, L.B.

“…The origins and genetic affinities of the more than 500 tribal populations living in South Asia are widely disputed. This may reflect differential…”
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A variant of Freeman-Sheldon syndrome maps to 11p15.5-pter by KRAKOWIAK, P. A, O'QUINN, J. R, BOHNSACK, J. F, WATKINS, W. S, CAREY, J. C, JORDE, L. B, BAMSHAD, M

“…Distal arthrogryposis type 1 (DA1) and Freeman-Sheldon syndrome (FSS) are the two most common known causes of inherited multiple congenital contractures. We…”
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Human Population Genetic Structure and Inference of Group Membership by Bamshad, Michael J., Wooding, Stephen, Watkins, W. Scott, Ostler, Christopher T., Batzer, Mark A., Jorde, Lynn B.

“…A major goal of biomedical research is to develop the capability to provide highly personalized health care. To do so, it is necessary to understand the…”
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Linkage disequilibrium patterns vary with chromosomal location : a case study from the von Willebrand factor region by WATKINS, W. S, ZENGER, R, O'BRIEN, E, NYMAN, D, ERIKSSON, A. W, RENLUND, M, JORDE, L. B

“…Linkage disequilibrium analysis has been used as a tool for analyzing marker order and locating disease genes. Under appropriate circumstances, disequilibrium…”
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Gene mapping in isolated populations: new roles for old friends? by Jorde, L B, Watkins, W S, Kere, J, Nyman, D, Eriksson, A W

“…Population isolates are increasingly being used in attempts to map genes underlying complex diseases. To further explore the utility of isolates for this…”
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