Search Results - "Watkins, Robert W."

Data-Driven Dose-Volume Histogram Prediction by Polizzi, Mitchell, Watkins, Robert W., Watkins, William T.

“…To evaluate dose-volume histogram (DVH) prediction from prior radiation therapy data. An Oncospace radiation therapy database was constructed including images,…”
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Developing steady and dynamic ORP models for mercury emissions control in power plants using WFGD operating data by Lv, You, Romero, Carlos E., Charles, Joshua, Pauvlinch, Kayla A., Watkins, Robert W.

“…•Steady and dynamic ORP models are developed using LSSVM and WFGD operating data.•Input parameters are analyzed to develop the steady ORP model.•Time delays of…”
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Antiplatelet and Antiproliferative Effects of SCH 51866, a Novel Type 1 and Type 5 Phosphodiesterase Inhibitor by Vemulapalli, Subbarao, Watkins, Robert W, Chintala, Madhu, Davis, Harry, Ahn, Ho-Sam, Fawzi, Ahmad, Tulshian, Deen, Chiu, Peter, Chatterjee, Meeta, Lin, Chin-Chung, Sybertz, Edmund J

“…SUMMARYSCH 51866 is a potent and selective PDE1 and PDE5 inhibitor. The antiplatelet, antiproliferative, and hemodynamic effects of SCH 51866 were compared…”
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The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs by Davis, Harry R., Pula, Kathyrn K., Alton, Kevin B., Burrier, Robert E., Watkins, Robert W.

“…Ezetimibe (SCH 58235) and SCH 48461 are potent cholesterol absorption inhibitors, which cause significant decreases in plasma cholesterol levels in…”
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Disparate effects of thrombin receptor activating peptide on platelets and peripheral vasculature in rats by Chintala, Madhu S, Chiu, Peter J.S, Bernadino, Vernon, Tetzloff, Glen G, Tedesco, Richard, Sabin, Crawford, Watkins, Robert W, Sybertz, Edmund J

“…The hemodynamic and platelet effects of the thrombin receptor activating peptide SFLLRN (TRAP) were evaluated in rats. TRAP failed to aggregate rat platelets…”
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SCH 57790, a selective muscarinic M2 receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals by CAREY, Galen J, BILLARD, William, TEDESCO, Richard P, WATKINS, Robert W, COFFIN, Vicki L, BINCH, Herbert III, COHEN-WILLIAMS, Mary, CROSBY, Gordon, GRZELAK, Michael, GUZIK, Henry, KOZLOWSKI, Joseph A, LOWE, Derek B, POND, Annamarie J

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Potent Tetracyclic Guanine Inhibitors of PDE1 and PDE5 Cyclic Guanosine Monophosphate Phosphodiesterases with Oral Antihypertensive Activity by Ahn, Ho-Sam, Bercovici, Ana, Boykow, George, Bronnenkant, Alan, Chackalamannil, Samuel, Chow, Jason, Cleven, Renee, Cook, John, Czarniecki, Michael, Domalski, Carol, Fawzi, Ahmad, Green, Michael, Gündes, Asli, Ho, Ginny, Laudicina, Malvina, Lindo, Neil, Ma, Ke, Manna, Mahua, McKittrick, Brian, Mirzai, Bita, Nechuta, Terry, Neustadt, Bernard, Puchalski, Chester, Pula, Kathryn, Silverman, Lisa, Smith, Elizabeth, Stamford, Andrew, Tedesco, Richard P, Tsai, Hsingan, Tulshian, Deen, Vaccaro, Henry, Watkins, Robert W, Weng, Xiaoyu, Witkowski, Joseph T, Xia, Yan, Zhang, Hongtao

“…Tetracyclic guanines have been shown to be potent and selective inhibitors of the cGMP-hydrolyzing enzymes PDE1 and PDE5. In general, these compounds are…”
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Neutral metalloendopeptidase inhibitors as ANF potentiators: sites and mechanisms of action by Sybertz, Jr, E J, Chiu, P J, Watkins, R W, Vemulapalli, S

“…Inhibition of the enzyme neutral metalloendopeptidase potentiates responses to atrial natriuretic factor and elicits reductions of blood pressure in…”
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SCH 412499: biodistribution and safety of an adenovirus containing P21(WAF-1/CIP-1) following subconjunctival injection in Cynomolgus monkeys by Veneziale, Robert W, Bral, Christopher M, Sinha, Dinesh P, Watkins, Robert W, Cartwright, Mark E, Rosenblum, Irwin Y, Treinen, Kimberley A, Kishnani, Narendra S, Nelson, Joyce, Chen, Zoe, Faha, Barbara, Maneval, D, Munger, Robert J, Cai, Xiao-Yan, Cullen, Constance, Arezzo, Joseph C

“…Monkey studies were conducted for the preclinical safety assessment of SCH 412499, an adenovirus encoding p21, administered by subconjunctival injection prior…”
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SCH 412499: Biodistribution and Safety of an Adenovirus Containing P21WAF-1 CIP-1 Following Subconjunctival Injection in Cynomolgus Monkeys by Veneziale, Robert W., Bral, Christopher M., Sinha, Dinesh P., Watkins, Robert W., Cartwright, Mark E., Rosenblum, Irwin Y., Treinen, Kimberley A., Kishnani, Narendra S., Nelson, Joyce, Chen, Zoe, Faha, Barbara, Maneval, D., Munger, Robert J., Cai, Xiao-Yan, Cullen, Constance, Arezzo, Joseph C.

“…Monkey studies were conducted for the preclinical safety assessment of SCH 412499, an adenovirus encoding p21, administered by subconjunctival injection prior…”
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Disparate effects of phosphoramidon on blood pressure in SHR and DOCA-salt hypertensive rats by Vemulapalli, S, Watkins, R W, Brown, A, Cook, J, Bernardino, V, Chiu, P J

“…Phosphoramidon inhibits both endothelin converting enzyme (ECE) and neutral metalloendopeptidase (NEP). The contribution of ECE and NEP inhibition to the…”
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Mercaptoacyl aminoacid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives by Neustadt, Bernard R, Smith, Elizabeth M, Nechuta, Terry L, Bronnenkant, Alan A, Haslanger, Martin F, Watkins, Robert W, Foster, Caroline J, Sybertz, Edmund J

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Effects of the antihypertensive dilevalol on aortic compliance in anesthetized dogs by Watkins, R W, Sybertz, E J, Antonellis, A, Pula, K, Rivelli, M

“…The present study examined the actions of dilevalol, an antihypertensive beta-adrenoceptor blocker with arterial vasodilator actions, on aortic compliance (AC)…”
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Hemodynamic actions of a synthetic atrial natriuretic factor by Baum, T, Sybertz, E J, Watkins, R W, Nelson, S, Coleman, W, Pula, K K, Prioli, N, Rivelli, M, Grossman, A

“…The recently discovered atrial natriuretic factor (ANF), as well as synthetic ANF, has been demonstrated to produce diuresis and vasodilation. However, the…”
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Pharmacologic, metabolic, and toxicologic profile of spirapril (SCH 33844), a new angiotensin converting inhibitor by Sybertz, E J, Watkins, R W, Ahn, H S, Baum, T, La Rocca, P, Patrick, J, Leitz, F

“…Spirapril (SCH 33844; 7-N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-(S)-alanyl-1,4-dithia- 7-azaspiro[4,4]-nonane-8(S)-carboxylic acid) is a new…”
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SCH 57790, a selective muscarinic M 2 receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals by Carey, Galen J., Billard, William, Binch, Herbert, Cohen-Williams, Mary, Crosby, Gordon, Grzelak, Michael, Guzik, Henry, Kozlowski, Joseph A., Lowe, Derek B., Pond, Annamarie J., Tedesco, Richard P., Watkins, Robert W., Coffin, Vicki L.

“…The present studies were designed to assess whether the novel muscarinic M 2 receptor antagonist…”
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Effects of the antihypertensive dilevalol on large artery compliance in anesthetized dogs by Watkins, R W, Sybertz, E J, Antonellis, A, Pula, K, Rivelli, M

“…The present study examined the actions of dilevalol, an antihypertensive beta-adrenoceptor blocker with arterial vasodilator actions, upon aortic compliance…”
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Antihypertensive activity of SCH 31846, a non-sulfhydryl angiotensin-converting enzyme inhibitor by Baum, T, Sybertz, E J, Watkins, R W, Ahn, H S, Nelson, S, Eynon, E, Vander Vliet, G, Pula, K K, Sabin, C, Desiderio, D M, Becker, F T, Vemulapalli, S

“…The antihypertensive, hemodynamic, and autonomic actions of SCH 31846, a new, potent and long-acting non-sulfhydryl angiotensin-converting enzyme (ACE)…”
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SCH 412499: Biodistribution and Safety of an Adenovirus Containing P21 WAF-1/CIP-1 Following Subconjunctival Injection in Cynomolgus Monkeys by Veneziale, Robert W., Bral, Christopher M., Sinha, Dinesh P., Watkins, Robert W., Cartwright, Mark E., Rosenblum, Irwin Y., Treinen, Kimberley A., Kishnani, Narendra S., Nelson, Joyce, Chen, Zoe, Faha, Barbara, Maneval, D., Munger, Robert J., Cai, Xiao-Yan, Cullen, Constance, Arezzo, Joseph C.

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Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anesthetized rats by CHINTALA, M. S, CHIU, P. J. S, SUBBARAO VEMULAPALLI, WATKINS, R. W, SYBERTZ, E. J

“…The relative importance of endothelial derived relaxing factor (EDRF)/nitric oxide (NO) in maintaining kidney function in normal condition and in acute renal…”
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