Search Results - "Watkins, Michael A"

Direct evidence of 2-cyano-2-propoxy radical activity during AIBN-based oxidative stress testing in acetonitrile-water solvent systems by Watkins, Michael A, Pitzenberger, Steven, Harmon, Paul A

“…Oxidative susceptibility testing was performed on a drug substance containing a methoxy-naphthalene moiety. 2,2'-azobisisobutyronitrile (AIBN) was employed to…”
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Impact of glass corrosion on drug substance stability by Watkins, Michael A, Iacocca, Ronald G, Shelbourn, Timothy L, Dong, Xia, Stobba-Wiley, Carolyn

“…The delamination of glass contact surfaces because of hydrolytic instability has been well documented. However, the lack of glass surface integrity can also…”
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Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid–Base Catalyst with Recycle by Tsukanov, Sergey V, Johnson, Martin D, May, Scott A, Rosemeyer, Morgan, Watkins, Michael A, Kolis, Stanley P, Yates, Matthew H, Johnston, Jeffrey N

“…A stereoselective aza-Henry reaction between an arylnitromethane and Boc-protected aryl aldimine using a homogeneous Brønsted acid–base catalyst was translated…”
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Investigation of the mechanism of racemization of litronesib in aqueous solution: unexpected base-catalyzed inversion of a fully substituted carbon chiral center by Baertschi, Steven W, Jansen, Patrick J, Montgomery, Robert M, Smith, William K, Draper, Jerry R, Myers, David P, Houghton, Peter G, Sharp, V Scott, Guisbert, Andrea L, Zhuang, Hong, Watkins, Michael A, Stephenson, Gregory A, Harris, Thomas M

“…Mitosis inhibitor (R)-litronesib (LY2523355) is a 1,3,4-thiadiazoline-bearing phenyl and N-(2-ethylamino)ethanesulfonamido-methyl substituents on tetrahedral…”
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Functional Group Selective Ion/Molecule Reactions:  Mass Spectrometric Identification of the Amido Functionality in Protonated Monofunctional Compounds by Campbell, Karinna M, Watkins, Michael A, Li, Sen, Fiddler, Marc N, Winger, Brian, Kenttämaa, Hilkka I

“…A mass spectrometric method was developed for the screening of the amido functionality in monofunctional protonated analytes. This method is based on selective…”
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Ion−Molecule Reactions for the Characterization of Polyols and Polyol Mixtures by ESI/FT-ICR Mass Spectrometry by Watkins, Michael A, Winger, Brian E, Shea, Ryan C, Kenttämaa, Hilkka I

“…A mass spectrometric method is described for the identification and counting of hydroxyl groups in an analyte. Analytes introduced into a FT-ICR mass…”
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Ion−Molecule Reactions for Mass Spectrometric Identification of Functional Groups in Protonated Oxygen-Containing Monofunctional Compounds by Watkins, Michael A, Price, Jason M, Winger, Brian E, Kenttämaa, Hilkka I

“…Protonated oxygen-containing monofunctional compounds react with selected methoxyborane reagents by proton transfer followed by nucleophilic substitution of…”
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Compound Screening for the Presence of the Primary N-Oxide Functionality via Ion−Molecule Reactions in a Mass Spectrometer by Watkins, Michael A, WeWora, Danielle V, Li, Sen, Winger, Brian E, Kenttämaa, Hilkka I

“…A mass spectrometry method is presented for the identification of compounds that contain the primary N-oxide functional group. This method utilizes a gas-phase…”
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Reliability of goniometric measurements and visual estimates of knee range of motion obtained in a clinical setting by Watkins, M A, Riddle, D L, Lamb, R L, Personius, W J

“…The purpose of this study was to examine the intratester and intertester reliability for goniometric measurements of knee flexion and extension passive range…”
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Laser desorption in transmission geometry inside a Fourier-transform ion cyclotron resonance mass spectrometer by Pérez, James, Petzold, Christopher J., Watkins, Michael A., Vaughn, Weldon E., Kenttämaa, Hilkka I.

“…We report here the first application of laser desorption (LD) in transmission geometry (backside irradiation of the sample through a transparent support)…”
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Ion–molecule reactions of trimethylborate allow the mass spectrometric identification and counting of functional groups in protonated bifunctional oxygen-containing compounds and polyols by Somuramasami, Jayalakshmi, Duan, Penggao, Watkins, Michael A., Winger, Brian E., Kenttamaa, Hilkka I.

“…A mass spectrometric method has been developed for the identification of functional groups in unknown bifunctional oxygen-containing compounds and for the…”
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The reactivity of metallated nitrenium ions studied by FT-ICR by Yurkovich, Michael J., Duan, Penggao, Shea, Ryan C., Watkins, Michael A., Mandell, Sarah M., Tippmann, Eric M., Jason Li, Sen, Platz, Matthew S., Kenttämaa, Hilkka I.

“…Two metallated nitrenium ions show drastically different reactivity. While the Mg-nitrenium ion reacts by radical mechanisms, the Cu-nitrenium ion follows…”
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Rearrangement of phenylcarbene radical cation to dehydrotropylium cation by Watkins, Michael A., Nelson, Eric D., Tichy, Shane E., Kenttämaa, Hilkka I.

“…Dichlorocarbene radical cation reacts with benzaldehyde in the gas phase by oxygen radical anion abstraction, generating a new carbene radical cation…”
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