Search Results - "Watkins, Laura C."

Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics by Watkins, Laura C, DeGrado, William F, Voth, Gregory A

“…Prevalent resistance to inhibitors that target the influenza A M2 proton channel has necessitated a continued drug design effort, supported by a sustained…”
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Multiscale Simulation of an Influenza A M2 Channel Mutant Reveals Key Features of Its Markedly Different Proton Transport Behavior by Watkins, Laura C, DeGrado, William F, Voth, Gregory A

“…The influenza A M2 channel, a prototype for viroporins, is an acid-activated viroporin that conducts protons across the viral membrane, a critical step in the…”
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Proton-Induced Conformational and Hydration Dynamics in the Influenza A M2 Channel by Watkins, Laura C, Liang, Ruibin, Swanson, Jessica M. J, DeGrado, William F, Voth, Gregory A

“…The influenza A M2 protein is an acid-activated proton channel responsible for acidification of the inside of the virus, a critical step in the viral life…”
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Transient water wires mediate selective proton transport in designed channel proteins by Kratochvil, Huong T., Watkins, Laura C., Mravic, Marco, Thomaston, Jessica L., Nicoludis, John M., Somberg, Noah H., Liu, Lijun, Hong, Mei, Voth, Gregory A., DeGrado, William F.

“…Selective proton transport through proteins is essential for forming and using proton gradients in cells. Protons are conducted along hydrogen-bonded ‘wires’…”
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A Military Case Review Method to Determine and Record the Mechanism of Injury (BioTab) from In-Theater Attacks by Danelson, Kerry A, Frounfelker, Patricia, Pizzolato-Heine, Karen, Valentine, Raymond, Watkins, Laura C, Tegtmeyer, Michael, Bolte, John H, Hardy, Warren N, Loftis, Kathryn L

“…Abstract A recent study of all mounted vehicle underbody blast attacks found that 21% of Abbreviated Injury Scale Severity 2+ injuries in the Joint Trauma…”
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Multiscale Simulation of an Influenza A M2 Channel Mutant Reveals Key Features of Its Markedly Different Proton Transport Behavior by Watkins, Laura C., DeGrado, William F., Voth, Gregory A.

“…Not provided…”
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