Search Results - "Watkins, Elyse A."

Suppression of Rheumatoid Arthritis by Enhanced Lymph Node Trafficking of Engineered Interleukin‐10 in Murine Models by Yuba, Eiji, Budina, Erica, Katsumata, Kiyomitsu, Ishihara, Ako, Mansurov, Aslan, Alpar, Aaron T., Watkins, Elyse A., Hosseinchi, Peyman, Reda, Joseph W., Lauterbach, Abigail L., Nguyen, Mindy, Solanki, Ani, Kageyama, Takahiro, Swartz, Melody A., Ishihara, Jun, Hubbell, Jeffrey A.

“…Objective Rheumatoid arthritis (RA) is a major autoimmune disease that causes synovitis and joint damage. Although clinical trials have been performed using…”
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Soluble N-Acetylgalactosamine-Modified Antigens Enhance Hepatocyte-Dependent Antigen Cross-Presentation and Result in Antigen-Specific CD8 + T Cell Tolerance Development by Damo, Martina, Wilson, D Scott, Watkins, Elyse A, Hubbell, Jeffrey A

“…Hepatocytes compose up to 80% of the total liver and have been indicated as important players in the induction of immunologic tolerance in this organ. We show…”
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Lymph Node-Targeted Synthetically Glycosylated Antigen Leads to Antigen-Specific Immunological Tolerance by Maulloo, Chitavi D, Cao, Shijie, Watkins, Elyse A, Raczy, Michal M, Solanki, Ani S, Nguyen, Mindy, Reda, Joseph W, Shim, Ha-Na, Wilson, D Scott, Swartz, Melody A, Hubbell, Jeffrey A

“…Inverse vaccines that tolerogenically target antigens to antigen-presenting cells (APCs) offer promise in prevention of immunity to allergens and protein drugs…”
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BACE Inhibitor Clinical Trials for Alzheimer's Disease by Watkins, Elyse A, Vassar, Robert

“…The amyloid hypothesis posits that the amyloid-β aggregates in the brain initiate a cascade of events that eventually lead to neuron loss and Alzheimer's…”
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Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant by Gray, Laura T., Raczy, Michal M., Briquez, Priscilla S., Marchell, Tiffany M., Alpar, Aaron T., Wallace, Rachel P., Volpatti, Lisa R., Sasso, Maria Stella, Cao, Shijie, Nguyen, Mindy, Mansurov, Aslan, Budina, Erica, Watkins, Elyse A., Solanki, Ani, Mitrousis, Nikolaos, Reda, Joseph W., Yu, Shann S., Tremain, Andrew C., Wang, Ruyi, Nicolaescu, Vlad, Furlong, Kevin, Dvorkin, Steve, Manicassamy, Balaji, Randall, Glenn, Wilson, D. Scott, Kwissa, Marcin, Swartz, Melody A., Hubbell, Jeffrey A.

“…The SARS-CoV-2 virus has caused an unprecedented global crisis, and curtailing its spread requires an effective vaccine which elicits a diverse and robust…”
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Targeted Polymersome Delivery of a Stapled Peptide for Drugging the Tumor Protein p53:BCL-2-Family Axis in Diffuse Large B‑Cell Lymphoma by Schnorenberg, Mathew R., Hawley, Katrina M., Thomas-Toth, Anika T., Watkins, Elyse A., Tian, Yu, Ting, Jeffrey M., Leak, Logan B., Kucera, Isadora M., Raczy, Michal M., Kung, Andrew L., Hubbell, Jeffrey A., Tirrell, Matthew V., LaBelle, James L.

“…Diffuse large B-cell lymphoma (DLBCL) remains a formidable diagnosis in need of new treatment paradigms. In this work, we elucidated an opportunity for…”
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Engineered bridge protein with dual affinity for bone morphogenetic protein-2 and collagen enhances bone regeneration for spinal fusion by Briquez, Priscilla S, Tsai, Hsiu-Ming, Watkins, Elyse A, Hubbell, Jeffrey A

“…The revolutionizing efficacy of recombinant human bone morphogenetic protein (rhBMP-2) for clinical spinal fusion is hindered by safety issues associated with…”
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Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics by Wallace, Rachel P, Refvik, Kirsten C, Antane, Jennifer T, Brünggel, Kym, Tremain, Andrew C, Raczy, Michal R, Alpar, Aaron T, Nguyen, Mindy, Solanki, Ani, Slezak, Anna J, Watkins, Elyse A, Lauterbach, Abigail L, Cao, Shijie, Wilson, D Scott, Hubbell, Jeffrey A

“…Immunogenic biologics trigger an anti-drug antibody (ADA) response in patients that reduces efficacy and increases adverse reactions. Our laboratory has shown…”
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Mannose-Decorated Co-Polymer Facilitates Controlled Release of Butyrate to Accelerate Chronic Wound Healing by Lauterbach, Abigail L, Slezak, Anna J, Wang, Ruyi, Cao, Shijie, Raczy, Michal M, Watkins, Elyse A, Jimenez, Carlos J Medina, Hubbell, Jeffrey A

“…Butyrate is a key bacterial metabolite that plays an important and complex role in modulation of immunity and maintenance of epithelial barriers. Its…”
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Designing biofunctional immunotherapies by Watkins, Elyse A., Hubbell, Jeffrey A.

“…Intelligent design of materials for biomedical applications involves the development of technologies that are informed by an understanding of biological…”
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Synthetically glycosylated antigens for the antigen-specific suppression of established immune responses by Tremain, Andrew C., Wallace, Rachel P., Lorentz, Kristen M., Thornley, Thomas B., Antane, Jennifer T., Raczy, Michal R., Reda, Joseph W., Alpar, Aaron T., Slezak, Anna J., Watkins, Elyse A., Maulloo, Chitavi D., Budina, Erica, Solanki, Ani, Nguyen, Mindy, Bischoff, David J., Harrington, Jamie L., Mishra, Rabinarayan, Conley, Gregory P., Marlin, Romain, Dereuddre-Bosquet, Nathalie, Gallouët, Anne-Sophie, LeGrand, Roger, Wilson, D. Scott, Kontos, Stephan, Hubbell, Jeffrey A.

“…Inducing antigen-specific tolerance during an established immune response typically requires non-specific immunosuppressive signalling molecules. Hence,…”
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Prolonged residence of an albumin–IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis by Ishihara, Ako, Ishihara, Jun, Watkins, Elyse A., Tremain, Andrew C., Nguyen, Mindy, Solanki, Ani, Katsumata, Kiyomitsu, Mansurov, Aslan, Budina, Erica, Alpar, Aaron T., Hosseinchi, Peyman, Maillat, Lea, Reda, Joseph W., Kageyama, Takahiro, Swartz, Melody A., Yuba, Eiji, Hubbell, Jeffrey A.

“…Interleukin-4 (IL-4) suppresses the development of multiple sclerosis in a murine model of experimental autoimmune encephalomyelitis (EAE). Here, we show that,…”
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A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice by Cao, Shijie, Budina, Erica, Raczy, Michal M., Solanki, Ani, Nguyen, Mindy, Beckman, Taryn N., Reda, Joseph W., Hultgren, Kevin, Ang, Phillip S., Slezak, Anna J., Hesser, Lauren A., Alpar, Aaron T., Refvik, Kirsten C., Shores, Lucas S., Pillai, Ishita, Wallace, Rachel P., Dhar, Arjun, Watkins, Elyse A., Hubbell, Jeffrey A.

“…Butyrate—a metabolite produced by commensal bacteria—has been extensively studied for its immunomodulatory effects on immune cells, including regulatory T…”
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Persistent antigen exposure via the eryptotic pathway drives terminal T cell dysfunction by Watkins, Elyse A, Antane, Jennifer T, Roberts, Jaeda L, Lorentz, Kristen M, Zuerndorfer, Sarah, Dunaif, Anya C, Bailey, Lucas J, Tremain, Andrew C, Nguyen, Mindy, De Loera, Roberto C, Wallace, Rachel P, Weathered, Rachel K, Kontos, Stephan, Hubbell, Jeffrey A

“…Although most current treatments for autoimmunity involve broad immunosuppression, recent efforts have aimed to suppress T cells in an antigen-specific manner…”
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Polymersomes Decorated with the SARS-CoV‑2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity by Volpatti, Lisa R, Wallace, Rachel P, Cao, Shijie, Raczy, Michal M, Wang, Ruyi, Gray, Laura T, Alpar, Aaron T, Briquez, Priscilla S, Mitrousis, Nikolaos, Marchell, Tiffany M, Sasso, Maria Stella, Nguyen, Mindy, Mansurov, Aslan, Budina, Erica, Solanki, Ani, Watkins, Elyse A, Schnorenberg, Mathew R, Tremain, Andrew C, Reda, Joseph W, Nicolaescu, Vlad, Furlong, Kevin, Dvorkin, Steve, Yu, Shann S, Manicassamy, Balaji, LaBelle, James L, Tirrell, Matthew V, Randall, Glenn, Kwissa, Marcin, Swartz, Melody A, Hubbell, Jeffrey A

“…The COVID-19 pandemic underscores the need for rapid, safe, and effective vaccines. In contrast to some traditional vaccines, nanoparticle-based subunit…”
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Publisher Correction: Prolonged residence of an albumin–IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis by Ishihara, Ako, Ishihara, Jun, Watkins, Elyse A., Tremain, Andrew C., Nguyen, Mindy, Solanki, Ani, Katsumata, Kiyomitsu, Mansurov, Aslan, Budina, Erica, Alpar, Aaron T., Hosseinchi, Peyman, Maillat, Lea, Reda, Joseph W., Kageyama, Takahiro, Swartz, Melody A., Yuba, Eiji, Hubbell, Jeffrey A.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Adipose stem cell microbeads as production sources for chondrogenic growth factors by Lee, Christopher S D, Nicolini, Anthony M, Watkins, Elyse A, Burnsed, Olivia A, Boyan, Barbara D, Schwartz, Zvi

“…Microencapsulating stem cells in injectable microbeads can enhance delivery and localization, but their ability to act as growth factor production sources is…”
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Antigen targeted to the apoptotic pathway via dying erythrocytes leads to profound T cell exhaustion and tolerance by Watkins, Elyse A, Roberts, Jaeda, Dunaif, Anya A, De Loera, Robert, Bailey, Luke, Hubbell, Jeffrey

“…Abstract The current standard of care for autoimmune disease is administration of immunosuppressive agents that require a lifetime of treatment and leave…”
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