Search Results - "Watkin, Serena A J"
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On the utility of microfluidic systems to study protein interactions: advantages, challenges, and applications
Published in European biophysics journal (01-07-2023)“…Within the complex milieu of a cell, which comprises a large number of different biomolecules, interactions are critical for function. In this…”
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Structure–Function Studies of the Antibiotic Target l,l‑Diaminopimelate Aminotransferase from Verrucomicrobium spinosum Reveal an Unusual Oligomeric Structure
Published in Biochemistry (Easton) (23-06-2020)“…While humans lack the biosynthetic pathways for meso-diaminopimelate and l-lysine, they are essential for bacterial survival and are therefore attractive…”
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Plant DHDPR forms a dimer with unique secondary structure features that preclude higher-order assembly
Published in Biochemical journal (15-01-2018)“…Dihydrodipicolinate reductase (DHDPR) catalyses the second reaction in the diaminopimelate pathway of lysine biosynthesis in bacteria and plants. In contrast…”
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Laminar flow-based microfluidic systems for molecular interaction analysis-Part 1: Chip development, system operation and measurement setup
Published in Methods in enzymology (2023)“…The recent advent of laminar flow-based microfluidic systems for molecular interaction analysis has enabled transformative new profiling of proteins in regards…”
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Laminar flow-based microfluidic systems for molecular interaction analysis-Part 2: Data extraction, processing and analysis
Published in Methods in enzymology (2023)“…The rate at which fluorescently-labeled biomolecules, that are flowing at a constant speed in a microfluidic channel, diffuse into an adjacent buffer stream…”
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