Evaluation of serum calcium differences in hypertensive crises and control patients: A randomly matched case‐control study

Evaluation of serum calcium differences in hypertensive crises and control patients: A randomly matched case‐control study

The role of calcium in blood pressure has been widely studied among hypertensive patients; however, no study has explored the role of calcium in hypertensive crises. The primary objective of this study is to evaluate the differences in serum calcium levels between hypertensive crises patients and a...

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Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Vol. 23; no. 9; pp. 1767 - 1775
Main Authors: Onor, IfeanyiChukwu O., Duchane, Rose M., Payne, Casey J., Lambert, Hannah Naquin, Mitchner, DeMaurian M., Beyl, Robbie A., Nguyen, Anh T., Bilbe, Sarah E., White, Andrea Arriaga, Johnson, Mariah W., Faciane, Amber I., Kouagou, Emmanuel, Hymel, Stephanie A., Wates, Bria M., Sanders, Asia D., Vo, Phillip C. B., Bates, Jordan D., Spooner, Raven J., Gillard, Christopher J., Okogbaa, John I., Sarpong, Daniel F., Hadgu, Rim M., Okpechi, Samuel C., Onor, Gabriel I., Okoronkwo, Michael C., Naljayan, Mihran V., Guillory, Shane G., Sanne, Shane E.
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01-09-2021
John Wiley and Sons Inc
Wiley
Subjects:
Adolescent
Adult
Angina pectoris
Antihypertensives
Aortic aneurysms
Blood Pressure
Calcium
Case-Control Studies
Clinical medicine
Heart attacks
Hemorrhage
Hospitals
Humans
Hypertension
Hypertension - drug therapy
Hypertension - epidemiology
hypertension‐general
hypertensive crises
Kidney diseases
magnesium
Medical records
Original Paper
phosphorus
Retrospective Studies
Serum Calcium
hypertensive crises
magnesium
calcium
hypertension-general
phosphorus
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Summary:The role of calcium in blood pressure has been widely studied among hypertensive patients; however, no study has explored the role of calcium in hypertensive crises. The primary objective of this study is to evaluate the differences in serum calcium levels between hypertensive crises patients and a 1:1 random matched controls (age‐, sex‐, race‐, diabetes, and body mass index matched). This study is a single‐center, retrospective, chart review, case‐control study of patients with hypertensive crises (case group) and patients without hypertensive crises (control group). Patients were included in the case group if they were 18 years of age or older with hypertensive crises and have a documented calcium level. The control group patients were required to be 18 years of age or older, have a documented calcium level, and have no diagnosis of hypertensive crises. The primary outcome of the study was to compare the mean serum calcium in patients with hypertensive crises vs patients without hypertensive crises. Five hundred and sixty‐six patients were included in the study: 283 patients in both the case group and control group. The primary outcome results showed that serum calcium concentration was not significantly different between the case group (8.99 ± 0.78 mg/dL) and control group (8.96 ± 0.75 mg/dL) (P = .606). This study found no significant difference in serum calcium levels in patients with hypertensive crises compared to a random matched control group. Larger observational or experimental studies may be useful to evaluate the effect of calcium on blood pressure in hypertensive crises.
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ISSN:1524-6175
1751-7176
DOI:10.1111/jch.14268